Prph2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Prph2
peripherin 2
MGI:102791

53 phenotypes from 6 alleles in 12 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Prph2^em1Sal/Prph2⁺ C57BL/6J-Prph2^em1Sal	abnormal electroretinogram waveform feature	J:342243
	abnormal photoreceptor outer segment morphology	J:342243
	abnormal retina cone cell outer segment morphology	J:342243
	abnormal synapse morphology	J:342243
	decreased a-wave amplitude	J:342243
	decreased b-wave amplitude	J:342243
	decreased total retina thickness	J:342243
	decreased visual acuity	J:342243
	eye inflammation	J:342243
	retina degeneration	J:342243
	retina outer nuclear layer degeneration	J:342243
	thin retina outer nuclear layer	J:342243
Prph2^em1Sal/Prph2^em1Sal C57BL/6J-Prph2^em1Sal	abnormal electroretinogram waveform feature	J:342243
	abnormal photoreceptor outer segment disc membrane morphology	J:342243
	abnormal photoreceptor outer segment morphology	J:342243
	abnormal retina cone cell inner segment morphology	J:342243
	abnormal retina cone cell outer segment morphology	J:342243
	abnormal retina outer plexiform layer morphology	J:342243
	abnormal retina photoreceptor morphology	J:342243
	abnormal retina pigment epithelium morphology	J:342243
	abnormal synapse morphology	J:342243
	decreased a-wave amplitude	J:342243
	decreased b-wave amplitude	J:342243
	decreased total retina thickness	J:342243
	decreased visual acuity	J:342243
	disorganized photoreceptor inner segment	J:342243
	disorganized photoreceptor outer segment	J:342243
	eye inflammation	J:342243
	increased microglial cell activation	J:342243
	retina degeneration	J:342243
	retina gliosis	J:342243
	retina outer nuclear layer degeneration	J:342243
	short photoreceptor inner segment	J:342243
	short photoreceptor outer segment	J:342243
	thick retina inner nuclear layer	J:342243
	thin retina outer nuclear layer	J:342243
Prph2^Nmf193/Prph2⁺ C57BL/6J-Prph2^Nmf193	abnormal cone electrophysiology	J:148636
	abnormal retina vasculature morphology	J:148636
	abnormal rod electrophysiology	J:148636
	disorganized retina outer nuclear layer	J:148636
	increased retina apoptosis	J:148636
	retina outer nuclear layer degeneration	J:148636
	retina spots	J:148636
	short photoreceptor outer segment	J:148636
Prph2^Nmf193/? C57BL/6J-Prph2^Nmf193/J	abnormal retina morphology	J:87349
Prph2^Nmf193/Prph2^Nmf193 C57BL/6J-Prph2^Nmf193	abnormal cone electrophysiology	J:148636
	abnormal rod electrophysiology	J:148636
	absent photoreceptor outer segment	J:148636
	increased susceptibility to age-related retinal degeneration	J:148636
	retina outer nuclear layer degeneration	J:148636
Prph2^Rd2/Prph2⁺ either: (involves: BALB/c * O20/A) or (involves: GR/A * O20/A) or (involves: O20/A * STS/A)	abnormal eye development	J:25582
	abnormal photoreceptor inner segment morphology	J:25582
	abnormal photoreceptor outer segment morphology	J:25582
	abnormal retina layer morphology	J:25582
	abnormal retina photoreceptor morphology	J:25582
	abnormal retina pigment epithelium morphology	J:25582
	increased retina cone cell number	J:25582
	thin retina outer nuclear layer	J:25582
Prph2^Rd2/Prph2⁺ either: (involves: C3H * O20/A) or (involves: C57BL/LiA * O20/A)	abnormal photoreceptor outer segment morphology	J:25582
Prph2^Rd2/Prph2⁺ either: C.O20-Prph2^Rd2 or C3.O20-Prph2^Rd2	abnormal Muller cell morphology	J:27850
	thin retina outer nuclear layer	J:27850
Prph2^Rd2/Prph2⁺ involves: O20/A	abnormal ocular fundus morphology	J:215646
	abnormal photoreceptor outer segment disc membrane morphology	J:215646
	abnormal rod electrophysiology	J:215646
	decreased a-wave amplitude	J:215646
	decreased b-wave amplitude	J:215646
	retina outer nuclear layer degeneration	J:215646
	short photoreceptor outer segment	J:215646
Prph2^Rd2/Prph2^Rd2 C3.O20-Prph2^Rd2	retina outer nuclear layer degeneration	J:12044
Prph2^Rd2/Prph2^Rd2 either: C.O20-Prph2^Rd2 or C3.O20-Prph2^Rd2	abnormal Muller cell morphology	J:27850
	thin retina outer nuclear layer	J:27850
Prph2^Rd2/Prph2^Rd2 involves: BALB/c * O20/A	decreased b-wave amplitude	J:76490
Prph2^Rd2/Prph2^Rd2 involves: BALB/c * O20/A	increased susceptibility to age-related retinal degeneration	J:76490
Prph2^Rd2/Prph2^Rd2 involves: O20/A	abnormal cone electrophysiology	J:215646
	abnormal ocular fundus morphology	J:215646
	abnormal rod electrophysiology	J:215646
	decreased a-wave amplitude	J:215646
	decreased b-wave amplitude	J:215646
	retina outer nuclear layer degeneration	J:215646
	retina photoreceptor degeneration	J:215646
Prph2^Rd2/Prph2^Rd2 O20/A-Prph2^Rd2	abnormal eye electrophysiology	J:7600
	abnormal macrophage morphology	J:6432
	abnormal retina cone cell morphology	J:6432
	abnormal retina development	J:6432
	abnormal retina morphology	J:6432
	abnormal retina neuronal layer morphology	J:6432
	abnormal retina outer nuclear layer morphology	J:6432
	abnormal retina photoreceptor layer morphology	J:6432
	abnormal retina photoreceptor morphology	J:6432
	abnormal retina pigment epithelium morphology	J:6432, J:25582
	abnormal retina rod cell outer segment morphology	J:6432
	absent photoreceptor outer segment	J:75095
	absent retina cone cells	J:6432
	absent retina rod cells	J:6051, J:6432
	decreased total retina thickness	J:6432
	increased susceptibility to age-related retinal degeneration	J:6051, J:6432
	retina neovascularization	J:6432
	retina outer nuclear layer degeneration	J:6051, J:75095
	thin retina outer nuclear layer	J:6432, J:7600
	thin retina outer plexiform layer	J:6432
Prph2^tm1.1Itl/Prph2⁺ Not Specified	abnormal ocular fundus morphology	J:215646
	abnormal photoreceptor outer segment disc membrane morphology	J:215646
	abnormal photoreceptor outer segment morphology	J:215646
	abnormal rod electrophysiology	J:215646
	decreased a-wave amplitude	J:215646
	decreased b-wave amplitude	J:215646
	retina outer nuclear layer degeneration	J:215646
	short photoreceptor outer segment	J:215646
Prph2^tm1.1Itl/Prph2^tm1.1Itl Not Specified	abnormal cone electrophysiology	J:215646
	abnormal ocular fundus morphology	J:215646
	abnormal photoreceptor outer segment disc membrane morphology	J:215646
	abnormal photoreceptor outer segment morphology	J:215646
	abnormal rod electrophysiology	J:215646
	decreased a-wave amplitude	J:215646
	decreased b-wave amplitude	J:215646
	retina outer nuclear layer degeneration	J:215646
	retina photoreceptor degeneration	J:215646
Prph2^tm1Nmc/Prph2⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal eye electrophysiology	J:76490
	abnormal photoreceptor outer segment morphology	J:76490
	abnormal retina pigment epithelium morphology	J:76490
	decreased retina rod cell number	J:76490
	disorganized photoreceptor outer segment	J:76490
	increased susceptibility to age-related retinal degeneration	J:76490
	short photoreceptor outer segment	J:76490
	thin retina outer nuclear layer	J:76490
Prph2^tm1Nmc/Prph2^tm1Nmc involves: 129S1/Sv * 129X1/SvJ	abnormal retina outer plexiform layer morphology	J:76490
	abnormal rod electrophysiology	J:76490
	absent photoreceptor outer segment	J:76490
	decreased retina rod cell number	J:76490
	increased retina apoptosis	J:76490
	increased susceptibility to age-related retinal degeneration	J:76490
	thin retina outer nuclear layer	J:76490
Prph2^tm4.1Itl/Prph2⁺ Not Specified	abnormal cone electrophysiology	J:292411
	abnormal ocular fundus morphology	J:292411
	abnormal photoreceptor outer segment morphology	J:292411
	abnormal rod electrophysiology	J:292411
	decreased a-wave amplitude	J:292411
	decreased b-wave amplitude	J:292411
	retina outer nuclear layer degeneration	J:292411
	retina photoreceptor degeneration	J:292411
	short photoreceptor outer segment	J:292411
	thin retina outer nuclear layer	J:292411
Prph2^tm4.1Itl/Prph2^tm4.1Itl Not Specified	abnormal cone electrophysiology	J:292411
	abnormal ocular fundus morphology	J:292411
	abnormal photoreceptor outer segment disc membrane morphology	J:292411
	abnormal photoreceptor outer segment morphology	J:292411
	abnormal retina vasculature morphology	J:292411
	abnormal rod electrophysiology	J:292411
	decreased a-wave amplitude	J:292411
	decreased b-wave amplitude	J:292411
	retina outer nuclear layer degeneration	J:292411
	retina photoreceptor degeneration	J:292411
	short photoreceptor outer segment	J:292411
	thin retina outer nuclear layer	J:292411

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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