Phb2 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Phb2
prohibitin 2
MGI:102520

19 phenotypes from 4 alleles in 6 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Phb2^tm1.1Tlan/Phb2^tm1.1Tlan involves: BALB/cJ * C57BL/6 * SJL	embryonic lethality between somite formation and embryo turning, complete penetrance	J:131699
Phb2^tm1Katz/Phb2⁺ 129S6/SvEvTac-Bcap37^tm1Katz	abnormal litter size	J:96817
	abnormal uterus morphology	J:96817
	increased uterus weight	J:96817
Phb2^tm1Katz/Phb2⁺ involves: 129S6/SvEvTac * C57BL/6	abnormal litter size	J:96817
	abnormal uterus morphology	J:96817
	increased susceptibility to weight gain	J:96817
	increased uterus weight	J:96817
	prenatal lethality, incomplete penetrance	J:96817
Phb2^tm1Katz/Phb2^tm1Katz 129S6/SvEvTac-Bcap37^tm1Katz	embryonic lethality, complete penetrance	J:96817
Phb2^tm1Katz/Phb2^tm1Katz involves: 129S6/SvEvTac * C57BL/6	embryonic lethality, complete penetrance	J:96817
Phb2^tm1Tlan/Phb2^tm1Tlan involves: C57BL/6 * SJL	abnormal mitochondrial morphology	J:131699
	decreased fibroblast proliferation	J:131699
	increased sensitivity to induced cell death	J:131699
Phb2^tm2.1Katz/Phb2⁺ Tg(Wap-cre)11738Mam/0 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	abnormal milk composition	J:178347
	abnormal nursing	J:178347
Phb2^tm2.1Katz/Phb2⁺ Pgr^tm2(cre)Lyd/Pgr⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal mammary gland duct morphology	J:178347
Phb2^tm2.1Katz/Phb2^tm2.1Katz Pgr^tm2(cre)Lyd/Pgr⁺ involves: 129S1/Sv * 129X1/SvJ	abnormal mammary gland duct morphology	J:178347
	abnormal mammary gland morphology	J:178347
	normal reproductive system phenotype	J:178347
Phb2^tm2.1Katz/Phb2^tm2.1Katz Tg(Wap-cre)11738Mam/0 involves: C57BL/6 * SJL	abnormal involution of the mammary gland	J:178347
	abnormal mammary gland alveolus morphology	J:178347
	abnormal mammary gland growth during lactation	J:178347
	abnormal milk composition	J:178347
	abnormal nursing	J:178347
	increased mammary gland apoptosis	J:178347

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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