Phb2^tm1Katz
Targeted Allele Detail

Summary

• Symbol: Phb2^tm1Katz
• Name: prohibitin 2; targeted mutation 1, Benita S Katzenellenbogen
• MGI ID: MGI:3574361
• Synonyms: REA^-
• Gene: Phb2 Location: Chr6:124689299-124693913 bp, + strand Genetic Position: Chr6, 59.17 cM
• Alliance: Phb2^tm1Katz page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:96817
• Parent Cell Line: TC1/TC-1 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The exon sequence encoding Pro12 to Val201 was replaced with a floxed neomycin resistance gene. (J:96817)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Phb2 Mutation: 22 strains or lines available

References

• Original: J:96817 Park SE, et al., Genetic deletion of the repressor of estrogen receptor activity (REA) enhances the response to estrogen in target tissues in vivo. Mol Cell Biol. 2005 Mar;25(5):1989-99
• All: 5 reference(s)