Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm1Katz mutation
(0 available);
any
Phb2 mutation
(22 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm1Katz mutation
(0 available);
any
Phb2 mutation
(22 available)
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Allelic
Composition |
Phb2tm1Katz/Phb2+
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Genetic
Background |
129S6/SvEvTac-Bcap37tm1Katz |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm1Katz mutation
(0 available);
any
Phb2 mutation
(22 available)
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reproductive system
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• the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation
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• females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight
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• exhibited smaller litter sizes than on a mixed 129S6/SvEvTac and C57BL/6 background
• litter size of the second-generation mice were reduced significantly from those of the first-generation mice (4.1 vs 6.1 pups)
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Allelic
Composition |
Phb2tm1Katz/Phb2+
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phb2tm1Katz mutation
(0 available);
any
Phb2 mutation
(22 available)
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mortality/aging
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• the numbers of heterozygous mutants were underrepresented among weaned pups but did not observe death after birth, indicating that some embryos may have died during a late gestational stage
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growth/size/body
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• heterozygous females exhibited a greater gain in body weight from 9 weeks of age to 26 weeks of age than in wildtype, but no differences in males
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reproductive system
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• the apical surface of the luminal epithelium in the uteri of estradiol treated females was more convoluted than the smooth apical surface in wildtype and showed luminal epithelium hyperproliferation
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• females treated with estradiol (E2) for 4 days had a 40% increase in uterine weight
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|
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• exhibited larger litter sizes than on the 129S6/SvEvTac coisogenic background
• litter sizes of second-generation mice were reduced significantly from those of the first-generation mice (5.9 vs 7.5 pups)
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Analysis Tools