GO Annotations Graph

• Symbol: Prox1
• Name: prospero homeobox 1
• ID: MGI:97772

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0050692	DNA binding domain binding	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	NAS	J:144217
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:144217
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:111764
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0050693	LBD domain binding	ISO	J:164563
Molecular Function	GO:0016922	nuclear receptor binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:213087
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:213087
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:170293
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:145843
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:213087
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:145843
Cellular Component	GO:0005634	nucleus	IDA	J:144217
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:142927
Cellular Component	GO:0005634	nucleus	IDA	J:142927
Cellular Component	GO:0005634	nucleus	IDA	J:171468
Cellular Component	GO:0005634	nucleus	IDA	J:170293
Biological Process	GO:0090425	acinar cell differentiation	IMP	J:183127
Biological Process	GO:0060414	aorta smooth muscle tissue morphogenesis	IMP	J:144217
Biological Process	GO:0055009	atrial cardiac muscle tissue morphogenesis	IMP	J:144217
Biological Process	GO:0060837	blood vessel endothelial cell differentiation	IMP	J:75859
Biological Process	GO:0061114	branching involved in pancreas morphogenesis	IMP	J:183127
Biological Process	GO:0008283	cell population proliferation	IMP	J:83185
Biological Process	GO:0021707	cerebellar granule cell differentiation	IMP	J:166777
Biological Process	GO:0007623	circadian rhythm	IEP	J:213087
Biological Process	GO:0021542	dentate gyrus development	IMP	J:166777
Biological Process	GO:0060059	embryonic retina morphogenesis in camera-type eye	IEP	J:83185
Biological Process	GO:0060214	endocardium formation	IMP	J:144217
Biological Process	GO:0010631	epithelial cell migration	IMP	J:63128
Biological Process	GO:0002194	hepatocyte cell migration	IMP	J:63128
Biological Process	GO:0070365	hepatocyte differentiation	IEP	J:154159
Biological Process	GO:0072574	hepatocyte proliferation	IMP	J:63128
Biological Process	GO:0048839	inner ear development	IMP	J:157908
Biological Process	GO:0070309	lens fiber cell morphogenesis	IMP	J:53431
Biological Process	GO:0002089	lens morphogenesis in camera-type eye	IMP	J:53431
Biological Process	GO:0046619	lens placode formation involved in camera-type eye formation	IEP	J:145843
Biological Process	GO:0001945	lymph vessel development	IMP	J:102652
Biological Process	GO:0001946	lymphangiogenesis	ISO	J:164563
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	ISO	J:164563
Biological Process	GO:0060836	lymphatic endothelial cell differentiation	IMP	J:142041
Biological Process	GO:0060838	lymphatic endothelial cell fate commitment	ISO	J:164563
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0070858	negative regulation of bile acid biosynthetic process	ISO	J:164563
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:213087
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0007406	negative regulation of neuroblast proliferation	IMP	J:83185
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:170293
Biological Process	GO:0045071	negative regulation of viral genome replication	ISO	J:164563
Biological Process	GO:0007405	neuroblast proliferation	IMP	J:83185
Biological Process	GO:0048664	neuron fate determination	IMP	J:83185
Biological Process	GO:0097150	neuronal stem cell population maintenance	IMP	J:166777
Biological Process	GO:0045787	positive regulation of cell cycle	IMP	J:53431
Biological Process	GO:1901978	positive regulation of cell cycle checkpoint	IMP	J:170293
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:83185
Biological Process	GO:0045737	positive regulation of cyclin-dependent protein serine/threonine kinase activity	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:2000979	positive regulation of forebrain neuron differentiation	IMP	J:166777
Biological Process	GO:0060421	positive regulation of heart growth	IMP	J:144217
Biological Process	GO:2000179	positive regulation of neural precursor cell proliferation	IMP	J:166777
Biological Process	GO:0060298	positive regulation of sarcomere organization	IMP	J:144217
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:111764
Biological Process	GO:0042752	regulation of circadian rhythm	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	ISO	J:164563
Biological Process	GO:0010468	regulation of gene expression	IMP	J:53431
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0048511	rhythmic process	IEA	J:60000
Biological Process	GO:0030240	skeletal muscle thin filament assembly	IMP	J:144217
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:111764
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:111764
Biological Process	GO:0048845	venous blood vessel morphogenesis	IMP	J:144217
Biological Process	GO:0055010	ventricular cardiac muscle tissue morphogenesis	IMP	J:144217
Biological Process	GO:0055005	ventricular cardiac myofibril assembly	IMP	J:144217
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:144217