GO Annotations Graph

• Symbol: Otx2
• Name: orthodenticle homeobox 2
• ID: MGI:97451

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0000987	cis-regulatory region sequence-specific DNA binding	TAS	J:226614
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:226614
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:266471
Molecular Function	GO:0005515	protein binding	IPI	J:99788
Molecular Function	GO:0005515	protein binding	IPI	J:89367
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IDA	J:63629
Cellular Component	GO:0030426	growth cone	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:189004
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IC	J:89367
Cellular Component	GO:0005634	nucleus	IDA	J:63629
Cellular Component	GO:0005634	nucleus	IDA	J:189004
Cellular Component	GO:0005634	nucleus	IDA	J:63629
Cellular Component	GO:0005634	nucleus	IDA	J:203109
Cellular Component	GO:0005634	nucleus	IDA	J:63629
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:226614
Biological Process	GO:0048856	anatomical structure development	IGI	J:70278
Biological Process	GO:0048856	anatomical structure development	IGI	J:70278
Biological Process	GO:0009887	animal organ morphogenesis	IMP	J:86636
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:46377
Biological Process	GO:0009952	anterior/posterior pattern specification	IGI	J:70278
Biological Process	GO:0009952	anterior/posterior pattern specification	IMP	J:83110
Biological Process	GO:0007411	axon guidance	ISO	J:164563
Biological Process	GO:0030154	cell differentiation	TAS	J:226614
Biological Process	GO:0045165	cell fate commitment	IMP	J:89367
Biological Process	GO:1990830	cellular response to leukemia inhibitory factor	IEP	J:163558
Biological Process	GO:0007417	central nervous system development	IMP	J:72725
Biological Process	GO:0007417	central nervous system development	IMP	J:83110
Biological Process	GO:0007417	central nervous system development	IMP	J:72725
Biological Process	GO:0048852	diencephalon morphogenesis	IGI	J:166617
Biological Process	GO:0071542	dopaminergic neuron differentiation	ISO	J:164563
Biological Process	GO:0071542	dopaminergic neuron differentiation	IMP	J:98336
Biological Process	GO:0009953	dorsal/ventral pattern formation	IMP	J:83110
Biological Process	GO:0007492	endoderm development	IGI	J:70278
Biological Process	GO:0042706	eye photoreceptor cell fate commitment	IMP	J:86636
Biological Process	GO:0030900	forebrain development	IGI	J:91012
Biological Process	GO:0030900	forebrain development	IGI	J:98539
Biological Process	GO:0030900	forebrain development	IMP	J:86636
Biological Process	GO:0030900	forebrain development	IGI	J:98539
Biological Process	GO:0030900	forebrain development	IMP	J:91012
Biological Process	GO:0030900	forebrain development	IMP	J:91012
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:53713
Biological Process	GO:0048382	mesendoderm development	IMP	J:226614
Biological Process	GO:0022037	metencephalon development	IGI	J:166617
Biological Process	GO:0030901	midbrain development	IGI	J:91011
Biological Process	GO:0030901	midbrain development	IMP	J:91012
Biological Process	GO:0030901	midbrain development	IMP	J:98336
Biological Process	GO:0030901	midbrain development	IMP	J:91012
Biological Process	GO:0030901	midbrain development	IGI	J:166617
Biological Process	GO:0007275	multicellular organism development	IEA	J:72247
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0060563	neuroepithelial cell differentiation	IMP	J:86636
Biological Process	GO:0048663	neuron fate commitment	IMP	J:224836
Biological Process	GO:0048663	neuron fate commitment	IMP	J:104370
Biological Process	GO:0048664	neuron fate determination	IMP	J:152847
Biological Process	GO:0048664	neuron fate determination	IMP	J:152847
Biological Process	GO:0048665	neuron fate specification	IMP	J:98336
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:224836
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:224836
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:74124
Biological Process	GO:0040019	positive regulation of embryonic development	IMP	J:74124
Biological Process	GO:2000543	positive regulation of gastrulation	IMP	J:74124
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:99788
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:109350
Biological Process	GO:0090009	primitive streak formation	IMP	J:74124
Biological Process	GO:0065003	protein-containing complex assembly	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:89367
Biological Process	GO:0032525	somite rostral/caudal axis specification	IMP	J:74124
Biological Process	GO:0021978	telencephalon regionalization	IMP	J:224836