GO Annotations Graph

• Symbol: Nhlh2
• Name: nescient helix loop helix 2
• ID: MGI:97324

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:93303
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:179377
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:93303
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:136071
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:136071
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:136071
Cellular Component	GO:0005634	nucleus	IEA	J:60000
Biological Process	GO:0006915	apoptotic process	IGI	J:125013
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0021535	cell migration in hindbrain	IGI	J:125013
Biological Process	GO:0021888	hypothalamus gonadotrophin-releasing hormone neuron development	IMP	J:199640
Biological Process	GO:0008584	male gonad development	IMP	J:39356
Biological Process	GO:0060179	male mating behavior	IMP	J:39356
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0042698	ovulation cycle	IMP	J:101925
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:148882
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:136071
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:93303
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628