Erbb2 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Erbb2
erb-b2 receptor tyrosine kinase 2
MGI:95410

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0043125	ErbB-3 class receptor binding	ISO	J:164563
Molecular Function	GO:0019838	growth factor binding	ISO	J:164563
Molecular Function	GO:0051879	Hsp90 protein binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:168371
Molecular Function	GO:0005515	protein binding	IPI	J:114070
Molecular Function	GO:0005515	protein binding	IPI	J:116074
Molecular Function	GO:0005515	protein binding	IPI	J:187564
Molecular Function	GO:0005515	protein binding	IPI	J:203534
Molecular Function	GO:0005515	protein binding	IPI	J:63225
Molecular Function	GO:0005515	protein binding	IPI	J:198542
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0004672	protein kinase activity	IEA	J:72247
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:155856
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:127663
Molecular Function	GO:0004713	protein tyrosine kinase activity	IGI	J:82728
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:47407
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:317053
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:34905
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:138989
Molecular Function	GO:0004713	protein tyrosine kinase activity	IDA	J:319897
Molecular Function	GO:0004713	protein tyrosine kinase activity	ISO	J:73065
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0001042	RNA polymerase I core binding	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0004714	transmembrane receptor protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0004888	transmembrane signaling receptor activity	ISO	J:164563
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	ISO	J:155856
Cellular Component	GO:0016324	apical plasma membrane	IDA	J:94401
Cellular Component	GO:0009925	basal plasma membrane	ISO	J:155856
Cellular Component	GO:0009925	basal plasma membrane	IBA	J:265628
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:164563
Cellular Component	GO:0016323	basolateral plasma membrane	ISO	J:155856
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	IDA	J:94401
Cellular Component	GO:0031410	cytoplasmic vesicle	IDA	J:198542
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005768	endosome	IEA	J:60000
Cellular Component	GO:0010008	endosome membrane	ISO	J:164563
Cellular Component	GO:0038143	ERBB3:ERBB2 complex	ISO	J:164563
Cellular Component	GO:0043219	lateral loop	ISO	J:155856
Cellular Component	GO:0016020	membrane	NAS	J:114116
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0005902	microvillus	ISO	J:155856
Cellular Component	GO:0043209	myelin sheath	IDA	J:90038
Cellular Component	GO:0031594	neuromuscular junction	IMP	J:180660
Cellular Component	GO:0031594	neuromuscular junction	IDA	J:180660
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:316874
Cellular Component	GO:0005886	plasma membrane	IDA	J:82728
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:47407
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:317053
Cellular Component	GO:0005886	plasma membrane	IDA	J:34905
Cellular Component	GO:0005886	plasma membrane	IDA	J:319897
Cellular Component	GO:0005886	plasma membrane	IDA	J:198542
Cellular Component	GO:0045211	postsynaptic membrane	ISO	J:155856
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0042734	presynaptic membrane	IDA	J:217137
Cellular Component	GO:0043235	receptor complex	ISO	J:164563
Cellular Component	GO:0043235	receptor complex	IBA	J:265628
Cellular Component	GO:0043235	receptor complex	ISO	J:194542
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:73065
Biological Process	GO:0071364	cellular response to epidermal growth factor stimulus	ISO	J:164563
Biological Process	GO:0071363	cellular response to growth factor stimulus	ISO	J:164563
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IGI	J:127663
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:47407
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:34905
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	ISO	J:34905
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:138989
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:319897
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:34905
Biological Process	GO:0038133	ERBB2-ERBB3 signaling pathway	IDA	J:317053
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IGI	J:82728
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	IDA	J:47407
Biological Process	GO:0038135	ERBB2-ERBB4 signaling pathway	ISO	J:157327
Biological Process	GO:0044849	estrous cycle	ISO	J:155856
Biological Process	GO:0010001	glial cell differentiation	ISO	J:155856
Biological Process	GO:0007507	heart development	IMP	J:77347
Biological Process	GO:0007507	heart development	IMP	J:45302
Biological Process	GO:0033080	immature T cell proliferation in thymus	IMP	J:116829
Biological Process	GO:0035556	intracellular signal transduction	ISO	J:164563
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:60191
Biological Process	GO:0008045	motor neuron axon guidance	IMP	J:60191
Biological Process	GO:0007275	multicellular organism development	IBA	J:265628
Biological Process	GO:0042552	myelination	IMP	J:75421
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IBA	J:265628
Biological Process	GO:0033088	negative regulation of immature T cell proliferation in thymus	IMP	J:116829
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0007399	nervous system development	IMP	J:94397
Biological Process	GO:0022008	neurogenesis	IBA	J:265628
Biological Process	GO:0007528	neuromuscular junction development	IMP	J:60191
Biological Process	GO:0030182	neuron differentiation	IBA	J:265628
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IDA	J:180660
Biological Process	GO:0099645	neurotransmitter receptor localization to postsynaptic specialization membrane	IMP	J:180660
Biological Process	GO:0048709	oligodendrocyte differentiation	IMP	J:145866
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0007422	peripheral nervous system development	ISO	J:155856
Biological Process	GO:0007422	peripheral nervous system development	IMP	J:45302
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0045785	positive regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:155856
Biological Process	GO:0008284	positive regulation of cell population proliferation	IBA	J:265628
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	ISO	J:164563
Biological Process	GO:0010628	positive regulation of gene expression	IMP	J:210551
Biological Process	GO:0043547	positive regulation of GTPase activity	IMP	J:178104
Biological Process	GO:0033674	positive regulation of kinase activity	IBA	J:265628
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:155856
Biological Process	GO:0043410	positive regulation of MAPK cascade	IBA	J:265628
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:155856
Biological Process	GO:0001934	positive regulation of protein phosphorylation	IMP	J:178104
Biological Process	GO:0090314	positive regulation of protein targeting to membrane	ISO	J:164563
Biological Process	GO:0046579	positive regulation of Ras protein signal transduction	ISO	J:155856
Biological Process	GO:0045943	positive regulation of transcription by RNA polymerase I	ISO	J:164563
Biological Process	GO:0045727	positive regulation of translation	ISO	J:164563
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:155856
Biological Process	GO:0046777	protein autophosphorylation	ISO	J:164563
Biological Process	GO:0006468	protein phosphorylation	IEA	J:72247
Biological Process	GO:0070372	regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0032886	regulation of microtubule-based process	ISO	J:164563
Biological Process	GO:0048678	response to axon injury	ISO	J:155856
Biological Process	GO:0007165	signal transduction	ISO	J:164563
Biological Process	GO:0048485	sympathetic nervous system development	ISO	J:155856
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	ISO	J:164563
Biological Process	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	IBA	J:265628
Biological Process	GO:0042060	wound healing	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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