GO Annotations Graph

• Symbol: Egf
• Name: epidermal growth factor
• ID: MGI:95290

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IEA	J:72247
Molecular Function	GO:0005154	epidermal growth factor receptor binding	ISO	J:155856
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IDA	J:3764
Molecular Function	GO:0005154	epidermal growth factor receptor binding	IDA	J:15798
Molecular Function	GO:0008083	growth factor activity	ISO	J:73065
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:168194
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:70074
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:26923
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:317462
Molecular Function	GO:0048018	receptor ligand activity	ISO	J:317649
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:48234
Molecular Function	GO:0048018	receptor ligand activity	IDA	J:83700
Cellular Component	GO:0070062	extracellular exosome	ISO	J:164563
Cellular Component	GO:0005576	extracellular region	TAS	Reactome:R-MMU-179883
Cellular Component	GO:0005615	extracellular space	ISO	J:155856
Cellular Component	GO:0005615	extracellular space	IDA	J:26923
Cellular Component	GO:0005615	extracellular space	IDA	J:70074
Cellular Component	GO:0005615	extracellular space	IDA	J:317462
Cellular Component	GO:0005615	extracellular space	ISO	J:317649
Cellular Component	GO:0005615	extracellular space	IDA	J:83700
Cellular Component	GO:0005615	extracellular space	IDA	J:28214
Cellular Component	GO:0005615	extracellular space	IDA	J:15417
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005886	plasma membrane	IDA	J:168194
Cellular Component	GO:0005886	plasma membrane	TAS	Reactome:R-MMU-179883
Cellular Component	GO:0005886	plasma membrane	IBA	J:265628
Biological Process	GO:0001525	angiogenesis	ISO	J:164563
Biological Process	GO:0048754	branching morphogenesis of an epithelial tube	IDA	J:97651
Biological Process	GO:0008283	cell population proliferation	IGI	J:94813
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0021930	cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:26923
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:70074
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:48234
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:83700
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IGI	J:28214
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:15798
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IDA	J:96642
Biological Process	GO:0038029	epidermal growth factor receptor signaling pathway via MAPK cascade	ISO	J:164563
Biological Process	GO:0050673	epithelial cell proliferation	IGI	J:94813
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	ISO	J:317649
Biological Process	GO:0038134	ERBB2-EGFR signaling pathway	IDA	J:317462
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:54980
Biological Process	GO:0060749	mammary gland alveolus development	IGI	J:54980
Biological Process	GO:0090370	negative regulation of cholesterol efflux	IDA	J:161670
Biological Process	GO:0051048	negative regulation of secretion	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:87101
Biological Process	GO:0090263	positive regulation of canonical Wnt signaling pathway	ISO	J:164563
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:88364
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:28214
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:28214
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:96642
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:73065
Biological Process	GO:0008284	positive regulation of cell population proliferation	IDA	J:34905
Biological Process	GO:0008284	positive regulation of cell population proliferation	IGI	J:89246
Biological Process	GO:0021940	positive regulation of cerebellar granule cell precursor proliferation	IDA	J:52548
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:175195
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0045740	positive regulation of DNA replication	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0045741	positive regulation of epidermal growth factor-activated receptor activity	ISO	J:164563
Biological Process	GO:0050679	positive regulation of epithelial cell proliferation	IGI	J:94813
Biological Process	GO:1905278	positive regulation of epithelial tube formation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:155856
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	ISO	J:155856
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:1900127	positive regulation of hyaluronan biosynthetic process	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	ISO	J:164563
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:38321
Biological Process	GO:0043410	positive regulation of MAPK cascade	IDA	J:105250
Biological Process	GO:0045840	positive regulation of mitotic nuclear division	ISO	J:164563
Biological Process	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	ISO	J:164563
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	IDA	J:170361
Biological Process	GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0042327	positive regulation of phosphorylation	ISO	J:164563
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	ISO	J:164563
Biological Process	GO:1902966	positive regulation of protein localization to early endosome	ISO	J:164563
Biological Process	GO:0061098	positive regulation of protein tyrosine kinase activity	IDA	J:3764
Biological Process	GO:0002092	positive regulation of receptor internalization	ISO	J:164563
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IDA	J:168265
Biological Process	GO:0090279	regulation of calcium ion import	ISO	J:164563
Biological Process	GO:0050730	regulation of peptidyl-tyrosine phosphorylation	IDA	J:77668
Biological Process	GO:2000008	regulation of protein localization to cell surface	ISO	J:164563
Biological Process	GO:0050708	regulation of protein secretion	ISO	J:155856
Biological Process	GO:0051223	regulation of protein transport	ISO	J:156343
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	IDA	J:175195