GO Annotations Graph

• Symbol: Dock8
• Name: dedicator of cytokinesis 8
• ID: MGI:1921396

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	ISO	J:164563
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IBA	J:265628
Molecular Function	GO:0005085	guanyl-nucleotide exchange factor activity	IDA	J:185165
Molecular Function	GO:0005515	protein binding	IPI	J:238772
Cellular Component	GO:0031252	cell leading edge	IBA	J:265628
Cellular Component	GO:0031252	cell leading edge	IDA	J:185165
Cellular Component	GO:0042995	cell projection	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0031256	leading edge membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Biological Process	GO:1990869	cellular response to chemokine	ISO	J:164563
Biological Process	GO:0036336	dendritic cell migration	IMP	J:220239
Biological Process	GO:0036336	dendritic cell migration	IGI	J:185165
Biological Process	GO:0036336	dendritic cell migration	IMP	J:185165
Biological Process	GO:0001771	immunological synapse formation	IMP	J:178763
Biological Process	GO:0061485	memory T cell proliferation	ISO	J:73065
Biological Process	GO:0070233	negative regulation of T cell apoptotic process	IMP	J:179651
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	ISO	J:164563
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	IMP	J:238772
Biological Process	GO:1903905	positive regulation of establishment of T cell polarity	IBA	J:265628
Biological Process	GO:0043547	positive regulation of GTPase activity	ISO	J:164563
Biological Process	GO:0043547	positive regulation of GTPase activity	IBA	J:265628
Biological Process	GO:2000406	positive regulation of T cell migration	IMP	J:238772
Biological Process	GO:2000406	positive regulation of T cell migration	ISO	J:164563
Biological Process	GO:2000406	positive regulation of T cell migration	IBA	J:265628
Biological Process	GO:0007264	small GTPase mediated signal transduction	IEA	J:72247