Sirt6 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Sirt6
sirtuin 6
MGI:1354161

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0016746	acyltransferase activity	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:202816
Molecular Function	GO:0031490	chromatin DNA binding	ISO	J:164563
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0140612	DNA damage sensor activity	ISO	J:164563
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:0035033	histone deacetylase regulator activity	ISO	J:164563
Molecular Function	GO:0106222	lncRNA binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0140677	molecular function activator activity	ISO	J:164563
Molecular Function	GO:0140677	molecular function activator activity	IDA	J:278647
Molecular Function	GO:0070403	NAD+ binding	IBA	J:265628
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	IDA	J:322374
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	IDA	J:322377
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	IDA	J:99908
Molecular Function	GO:0106274	NAD+-protein-arginine ADP-ribosyltransferase activity	IDA	J:322373
Molecular Function	GO:0017136	NAD-dependent histone deacetylase activity	ISO	J:164563
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	ISO	J:164563
Molecular Function	GO:0097372	NAD-dependent histone H3K18 deacetylase activity	IDA	J:322389
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:322389
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:167155
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:250994
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:322365
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	ISO	J:164563
Molecular Function	GO:0140765	NAD-dependent histone H3K56 deacetylase activity	IDA	J:278647
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	ISO	J:164563
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:250994
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:278647
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:167155
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:322365
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IDA	J:322389
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:167957
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IMP	J:322375
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	TAS	Reactome:R-MMU-9604841
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IBA	J:265628
Molecular Function	GO:0046969	NAD-dependent histone H3K9 deacetylase activity	IDA	J:278647
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:291806
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	ISO	J:164563
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:281991
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:288674
Molecular Function	GO:0034979	NAD-dependent protein deacetylase activity	IDA	J:254113
Molecular Function	GO:0140773	NAD-dependent protein demyristoylase activity	ISO	J:164563
Molecular Function	GO:0140774	NAD-dependent protein depalmitoylase activity	ISO	J:164563
Molecular Function	GO:0031491	nucleosome binding	ISO	J:164563
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0033558	protein lysine deacetylase activity	ISO	J:155856
Molecular Function	GO:0003723	RNA binding	IEA	J:60000
Molecular Function	GO:1904841	TORC2 complex binding	IDA	J:281991
Molecular Function	GO:0003714	transcription corepressor activity	IGI	J:219058
Molecular Function	GO:0003714	transcription corepressor activity	IBA	J:265628
Molecular Function	GO:0140416	transcription regulator inhibitor activity	ISO	J:164563
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:278647
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0099115	chromosome, subtelomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005783	endoplasmic reticulum	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9604828
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9604841
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:219046
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:99908
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005721	pericentric heterochromatin	ISO	J:164563
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IMP	J:112817
Biological Process	GO:0055007	cardiac muscle cell differentiation	IMP	J:322375
Biological Process	GO:0006325	chromatin organization	IEA	J:60000
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:214604
Biological Process	GO:0008340	determination of adult lifespan	ISO	J:164563
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:322389
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IDA	J:322373
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0042593	glucose homeostasis	IMP	J:112817
Biological Process	GO:0016575	histone deacetylation	ISO	J:164563
Biological Process	GO:0042181	ketone biosynthetic process	IMP	J:274744
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:219058
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:167957
Biological Process	GO:0045814	negative regulation of gene expression, epigenetic	ISO	J:164563
Biological Process	GO:0045721	negative regulation of gluconeogenesis	ISO	J:164563
Biological Process	GO:0046325	negative regulation of glucose import	IMP	J:167957
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:219058
Biological Process	GO:0045820	negative regulation of glycolytic process	IMP	J:167957
Biological Process	GO:0045820	negative regulation of glycolytic process	ISO	J:164563
Biological Process	GO:0042308	negative regulation of protein import into nucleus	IMP	J:250994
Biological Process	GO:0120186	negative regulation of protein localization to chromatin	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:278647
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:250994
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:322377
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	IDA	J:278647
Biological Process	GO:0010529	negative regulation of transposition	IMP	J:275081
Biological Process	GO:0010529	negative regulation of transposition	IDA	J:322377
Biological Process	GO:0031508	pericentric heterochromatin formation	ISO	J:164563
Biological Process	GO:1905555	positive regulation of blood vessel branching	ISO	J:164563
Biological Process	GO:1902732	positive regulation of chondrocyte proliferation	ISO	J:164563
Biological Process	GO:0120162	positive regulation of cold-induced thermogenesis	IMP	J:249895
Biological Process	GO:2000781	positive regulation of double-strand break repair	ISO	J:164563
Biological Process	GO:2000781	positive regulation of double-strand break repair	IDA	J:322389
Biological Process	GO:0045600	positive regulation of fat cell differentiation	IMP	J:250994
Biological Process	GO:0048146	positive regulation of fibroblast proliferation	IMP	J:112817
Biological Process	GO:1901727	positive regulation of histone deacetylase activity	ISO	J:164563
Biological Process	GO:0032024	positive regulation of insulin secretion	IDA	J:254113
Biological Process	GO:0046827	positive regulation of protein export from nucleus	ISO	J:164563
Biological Process	GO:0046827	positive regulation of protein export from nucleus	IDA	J:254113
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	IMP	J:278647
Biological Process	GO:0120187	positive regulation of protein localization to chromatin	IDA	J:278647
Biological Process	GO:2000738	positive regulation of stem cell differentiation	IMP	J:322365
Biological Process	GO:2000738	positive regulation of stem cell differentiation	IMP	J:322375
Biological Process	GO:2000738	positive regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:1902459	positive regulation of stem cell population maintenance	ISO	J:164563
Biological Process	GO:2000648	positive regulation of stem cell proliferation	IMP	J:112817
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:1901485	positive regulation of transcription factor catabolic process	ISO	J:164563
Biological Process	GO:1905564	positive regulation of vascular endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0003247	post-embryonic cardiac muscle cell growth involved in heart morphogenesis	ISO	J:155856
Biological Process	GO:0006476	protein deacetylation	ISO	J:164563
Biological Process	GO:0006476	protein deacetylation	IMP	J:254113
Biological Process	GO:0051697	protein delipidation	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	ISO	J:164563
Biological Process	GO:0031648	protein destabilization	IMP	J:167957
Biological Process	GO:1990166	protein localization to site of double-strand break	ISO	J:164563
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:291806
Biological Process	GO:0010569	regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0050994	regulation of lipid catabolic process	IMP	J:281991
Biological Process	GO:0019216	regulation of lipid metabolic process	IDA	J:288674
Biological Process	GO:1903076	regulation of protein localization to plasma membrane	ISO	J:164563
Biological Process	GO:0050708	regulation of protein secretion	ISO	J:164563
Biological Process	GO:0009411	response to UV	ISO	J:164563
Biological Process	GO:0031509	subtelomeric heterochromatin formation	ISO	J:164563

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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