GO Annotations Graph

• Symbol: Trp53bp1
• Name: transformation related protein 53 binding protein 1
• ID: MGI:1351320

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003684	damaged DNA binding	IDA	J:76360
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0042393	histone binding	IBA	J:265628
Molecular Function	GO:0035064	methylated histone binding	ISO	J:164563
Molecular Function	GO:0035064	methylated histone binding	IDA	J:240587
Molecular Function	GO:0002039	p53 binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:245264
Molecular Function	GO:0005515	protein binding	IPI	J:193246
Molecular Function	GO:0005515	protein binding	IPI	J:193247
Molecular Function	GO:0005515	protein binding	IPI	J:195061
Molecular Function	GO:0005515	protein binding	IPI	J:36914
Molecular Function	GO:0005515	protein binding	IPI	J:92518
Molecular Function	GO:0005515	protein binding	IPI	J:92518
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:191725
Molecular Function	GO:0042162	telomeric DNA binding	IDA	J:115639
Molecular Function	GO:0003712	transcription coregulator activity	ISO	J:164563
Molecular Function	GO:0008134	transcription factor binding	TAS	J:36914
Molecular Function	GO:0061649	ubiquitin modification-dependent histone binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000775	chromosome, centromeric region	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:144766
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:1990391	DNA repair complex	IDA	J:208295
Cellular Component	GO:0000776	kinetochore	IDA	J:74292
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0016604	nuclear body	IDA	J:174530
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:206106
Cellular Component	GO:0005657	replication fork	IDA	J:92518
Cellular Component	GO:0035861	site of double-strand break	IDA	J:195061
Cellular Component	GO:0035861	site of double-strand break	IDA	J:240587
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Biological Process	GO:0000077	DNA damage checkpoint signaling	IBA	J:265628
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:123598
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IDA	J:240590
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	IMP	J:195061
Biological Process	GO:0006303	double-strand break repair via nonhomologous end joining	ISO	J:164563
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IDA	J:240590
Biological Process	GO:2000042	negative regulation of double-strand break repair via homologous recombination	IMP	J:195061
Biological Process	GO:0045830	positive regulation of isotype switching	IMP	J:89802
Biological Process	GO:0045830	positive regulation of isotype switching	ISO	J:164563
Biological Process	GO:0045830	positive regulation of isotype switching	IMP	J:91130
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0051260	protein homooligomerization	ISO	J:164563
Biological Process	GO:0006355	regulation of DNA-templated transcription	TAS	J:36914