Msh6 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Msh6
mutS homolog 6
MGI:1343961

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043531	ADP binding	ISO	J:164563
Molecular Function	GO:0005524	ATP binding	ISO	J:164563
Molecular Function	GO:0008094	ATP-dependent activity, acting on DNA	ISO	J:164563
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity	IEA	J:72247
Molecular Function	GO:0003682	chromatin binding	IDA	J:110906
Molecular Function	GO:0003684	damaged DNA binding	IMP	J:59561
Molecular Function	GO:0003684	damaged DNA binding	IGI	J:59561
Molecular Function	GO:0003677	DNA binding	IGI	J:59561
Molecular Function	GO:0003677	DNA binding	IMP	J:59561
Molecular Function	GO:0003690	double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0000400	four-way junction DNA binding	ISO	J:164563
Molecular Function	GO:0032137	guanine/thymine mispair binding	ISO	J:164563
Molecular Function	GO:0032137	guanine/thymine mispair binding	IDA	J:92555
Molecular Function	GO:0032137	guanine/thymine mispair binding	IDA	J:111285
Molecular Function	GO:0000287	magnesium ion binding	ISO	J:164563
Molecular Function	GO:0035064	methylated histone binding	ISO	J:164563
Molecular Function	GO:0030983	mismatched DNA binding	ISO	J:164563
Molecular Function	GO:0030983	mismatched DNA binding	ISO	J:164563
Molecular Function	GO:0030983	mismatched DNA binding	IBA	J:265628
Molecular Function	GO:0032405	MutLalpha complex binding	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0032357	oxidized purine DNA binding	ISO	J:164563
Molecular Function	GO:0032142	single guanine insertion binding	ISO	J:164563
Molecular Function	GO:0032143	single thymine insertion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:110906
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005794	Golgi apparatus	ISO	J:164563
Cellular Component	GO:0043231	intracellular membrane-bounded organelle	ISO	J:164563
Cellular Component	GO:0032301	MutSalpha complex	ISO	J:164563
Cellular Component	GO:0032301	MutSalpha complex	IBA	J:265628
Cellular Component	GO:0032301	MutSalpha complex	IDA	J:111285
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:44428
Biological Process	GO:0008340	determination of adult lifespan	IMP	J:59561
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0097193	intrinsic apoptotic signaling pathway	IMP	J:85999
Biological Process	GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage	IMP	J:92555
Biological Process	GO:0045190	isotype switching	IGI	J:125031
Biological Process	GO:0045190	isotype switching	IMP	J:110906
Biological Process	GO:0006298	mismatch repair	ISO	J:155856
Biological Process	GO:0006298	mismatch repair	ISO	J:164563
Biological Process	GO:0006298	mismatch repair	IBA	J:265628
Biological Process	GO:0006298	mismatch repair	IMP	J:44428
Biological Process	GO:0006298	mismatch repair	IMP	J:115827
Biological Process	GO:0006298	mismatch repair	IGI	J:115827
Biological Process	GO:0006298	mismatch repair	IMP	J:92555
Biological Process	GO:0006298	mismatch repair	IMP	J:192085
Biological Process	GO:0006298	mismatch repair	ISO	J:198961
Biological Process	GO:0006298	mismatch repair	IMP	J:79726
Biological Process	GO:0006298	mismatch repair	IGI	J:73030
Biological Process	GO:0045910	negative regulation of DNA recombination	ISO	J:164563
Biological Process	GO:0045910	negative regulation of DNA recombination	IMP	J:59561
Biological Process	GO:0051096	positive regulation of helicase activity	ISO	J:164563
Biological Process	GO:0009411	response to UV	IMP	J:85999
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:125031
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:91293
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:110906
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:60285
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:110906
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:91293

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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