GO Annotations Graph

• Symbol: Parp1
• Name: poly (ADP-ribose) polymerase family, member 1
• ID: MGI:1340806

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003824	catalytic activity	IEA	J:60000
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	IDA	J:206572
Molecular Function	GO:0003684	damaged DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0008047	enzyme activator activity	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016757	glycosyltransferase activity	IEA	J:60000
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:155856
Molecular Function	GO:0042802	identical protein binding	ISO	J:164563
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0051287	NAD binding	ISO	J:155856
Molecular Function	GO:0140294	NAD DNA ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	ISO	J:155856
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	J:325974
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	J:190250
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	IDA	J:190250
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	ISO	J:200218
Molecular Function	GO:0003950	NAD+ ADP-ribosyltransferase activity	IMP	J:206572
Molecular Function	GO:0140806	NAD+- protein-aspartate ADP-ribosyltransferase activity	IDA	J:297184
Molecular Function	GO:0140806	NAD+- protein-aspartate ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0140822	NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IDA	J:297184
Molecular Function	GO:0140816	NAD+-histone H2BS6 serine ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0140817	NAD+-histone H3S10 serine ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:1990404	NAD+-protein ADP-ribosyltransferase activity	IDA	J:206795
Molecular Function	GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	IMP	J:325965
Molecular Function	GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	IDA	J:297184
Molecular Function	GO:0140807	NAD+-protein-glutamate ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0140815	NAD+-protein-histidine ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0140805	NAD+-protein-serine ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0140808	NAD+-protein-tyrosine ADP-ribosyltransferase activity	ISO	J:164563
Molecular Function	GO:0030331	nuclear estrogen receptor binding	ISO	J:155856
Molecular Function	GO:0031491	nucleosome binding	ISO	J:164563
Molecular Function	GO:0016779	nucleotidyltransferase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:170044
Molecular Function	GO:0005515	protein binding	IPI	J:162637
Molecular Function	GO:0005515	protein binding	IPI	J:167924
Molecular Function	GO:0005515	protein binding	IPI	J:180563
Molecular Function	GO:0005515	protein binding	IPI	J:201316
Molecular Function	GO:0005515	protein binding	IPI	J:306588
Molecular Function	GO:0005515	protein binding	IPI	J:219495
Molecular Function	GO:0005515	protein binding	IPI	J:157813
Molecular Function	GO:0005515	protein binding	IPI	J:190250
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0019901	protein kinase binding	ISO	J:164563
Molecular Function	GO:0070412	R-SMAD binding	ISO	J:155856
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	ISO	J:164563
Molecular Function	GO:0046332	SMAD binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0008270	zinc ion binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:163548
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:151441
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:218220
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005635	nuclear envelope	ISO	J:164563
Cellular Component	GO:0043596	nuclear replication fork	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	IDA	J:94965
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	IDA	J:94965
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:306588
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:151441
Cellular Component	GO:0005634	nucleus	IDA	J:325974
Cellular Component	GO:0005634	nucleus	TAS	J:78954
Cellular Component	GO:0032991	protein-containing complex	ISO	J:164563
Cellular Component	GO:0032991	protein-containing complex	IDA	J:154112
Cellular Component	GO:0032991	protein-containing complex	ISO	J:218220
Cellular Component	GO:0032993	protein-DNA complex	ISO	J:164563
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Cellular Component	GO:0090734	site of DNA damage	IDA	J:190250
Cellular Component	GO:0035861	site of double-strand break	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:164563
Biological Process	GO:0006915	apoptotic process	ISO	J:164563
Biological Process	GO:1990966	ATP generation from poly-ADP-D-ribose	ISO	J:164563
Biological Process	GO:0006284	base-excision repair	IMP	J:77259
Biological Process	GO:0048148	behavioral response to cocaine	IMP	J:206572
Biological Process	GO:0016051	carbohydrate biosynthetic process	ISO	J:155856
Biological Process	GO:1904646	cellular response to amyloid-beta	ISO	J:155856
Biological Process	GO:0032869	cellular response to insulin stimulus	ISO	J:164563
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0034599	cellular response to oxidative stress	ISO	J:218220
Biological Process	GO:0071451	cellular response to superoxide	IDA	J:202975
Biological Process	GO:0071560	cellular response to transforming growth factor beta stimulus	ISO	J:155856
Biological Process	GO:0034644	cellular response to UV	ISO	J:164563
Biological Process	GO:0046697	decidualization	IMP	J:311744
Biological Process	GO:0030592	DNA ADP-ribosylation	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	ISO	J:206795
Biological Process	GO:0006259	DNA metabolic process	IMP	J:73919
Biological Process	GO:0006259	DNA metabolic process	IMP	J:83068
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006281	DNA repair	IDA	J:190250
Biological Process	GO:0006281	DNA repair	TAS	J:78954
Biological Process	GO:0006302	double-strand break repair	ISO	J:164563
Biological Process	GO:0006302	double-strand break repair	IGI	J:170941
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0045087	innate immune response	IEA	J:60000
Biological Process	GO:0008152	metabolic process	IEA	J:60000
Biological Process	GO:0032042	mitochondrial DNA metabolic process	ISO	J:218220
Biological Process	GO:0043504	mitochondrial DNA repair	ISO	J:218220
Biological Process	GO:0007005	mitochondrion organization	ISO	J:218220
Biological Process	GO:0007005	mitochondrion organization	IMP	J:218220
Biological Process	GO:1904178	negative regulation of adipose tissue development	IDA	J:297184
Biological Process	GO:2001170	negative regulation of ATP biosynthetic process	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:297184
Biological Process	GO:0045824	negative regulation of innate immune response	IMP	J:325965
Biological Process	GO:0045824	negative regulation of innate immune response	ISO	J:164563
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:219495
Biological Process	GO:0032700	negative regulation of interleukin-17 production	IMP	J:219495
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	IMP	J:228143
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0034244	negative regulation of transcription elongation by RNA polymerase II	ISO	J:164563
Biological Process	GO:0010613	positive regulation of cardiac muscle hypertrophy	ISO	J:155856
Biological Process	GO:0032786	positive regulation of DNA-templated transcription, elongation	ISO	J:164563
Biological Process	GO:1905168	positive regulation of double-strand break repair via homologous recombination	ISO	J:164563
Biological Process	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	ISO	J:164563
Biological Process	GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway	ISO	J:155856
Biological Process	GO:0051901	positive regulation of mitochondrial depolarization	ISO	J:155856
Biological Process	GO:1904762	positive regulation of myofibroblast differentiation	ISO	J:155856
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:77719
Biological Process	GO:0060545	positive regulation of necroptotic process	IDA	J:117094
Biological Process	GO:1901216	positive regulation of neuron death	ISO	J:155856
Biological Process	GO:1900182	positive regulation of protein localization to nucleus	ISO	J:155856
Biological Process	GO:1903518	positive regulation of single strand break repair	ISO	J:164563
Biological Process	GO:1903518	positive regulation of single strand break repair	IGI	J:241443
Biological Process	GO:0060391	positive regulation of SMAD protein signal transduction	ISO	J:155856
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:2000679	positive regulation of transcription regulatory region DNA binding	ISO	J:155856
Biological Process	GO:0070213	protein auto-ADP-ribosylation	ISO	J:164563
Biological Process	GO:0016540	protein autoprocessing	ISO	J:155856
Biological Process	GO:0071168	protein localization to chromatin	ISO	J:164563
Biological Process	GO:0036211	protein modification process	ISO	J:155856
Biological Process	GO:0036211	protein modification process	ISO	J:218220
Biological Process	GO:0070212	protein poly-ADP-ribosylation	ISO	J:155856
Biological Process	GO:0070212	protein poly-ADP-ribosylation	ISO	J:164563
Biological Process	GO:0070212	protein poly-ADP-ribosylation	IDA	J:325974
Biological Process	GO:0070212	protein poly-ADP-ribosylation	IDA	J:206572
Biological Process	GO:1905051	regulation of base-excision repair	ISO	J:164563
Biological Process	GO:0050790	regulation of catalytic activity	ISO	J:164563
Biological Process	GO:0045188	regulation of circadian sleep/wake cycle, non-REM sleep	IMP	J:325961
Biological Process	GO:0044030	regulation of DNA methylation	ISO	J:155856
Biological Process	GO:0040009	regulation of growth rate	IMP	J:83068
Biological Process	GO:1903376	regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway	ISO	J:155856
Biological Process	GO:0032880	regulation of protein localization	ISO	J:206795
Biological Process	GO:1903516	regulation of single strand break repair	IMP	J:218220
Biological Process	GO:0010990	regulation of SMAD protein complex assembly	ISO	J:155856
Biological Process	GO:0071932	replication fork reversal	ISO	J:164563
Biological Process	GO:0023019	signal transduction involved in regulation of gene expression	ISO	J:155856
Biological Process	GO:0000723	telomere maintenance	IMP	J:83068
Biological Process	GO:0007179	transforming growth factor beta receptor signaling pathway	ISO	J:155856
Biological Process	GO:0050882	voluntary musculoskeletal movement	IGI	J:241443