GO Annotations Graph

• Symbol: Ptf1a
• Name: pancreas specific transcription factor, 1a
• ID: MGI:1328312

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:214089
Molecular Function	GO:0003682	chromatin binding	IDA	J:197142
Molecular Function	GO:0003677	DNA binding	IDA	J:50645
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:158304
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	IDA	J:158304
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0070888	E-box binding	IDA	J:183714
Molecular Function	GO:0005515	protein binding	IPI	J:62777
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:1943
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:125691
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-187247
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:125691
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-190093
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IC	J:50645
Cellular Component	GO:0005667	transcription regulator complex	ISO	J:155856
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:125691
Cellular Component	GO:0005667	transcription regulator complex	TAS	J:51571
Biological Process	GO:0035881	amacrine cell differentiation	IMP	J:115271
Biological Process	GO:0035881	amacrine cell differentiation	IMP	J:119184
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0045165	cell fate commitment	IMP	J:78710
Biological Process	GO:0045165	cell fate commitment	IMP	J:125691
Biological Process	GO:0021549	cerebellum development	ISO	J:164563
Biological Process	GO:0021549	cerebellum development	IMP	J:120017
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0006351	DNA-templated transcription	IDA	J:158304
Biological Process	GO:0031017	exocrine pancreas development	ISO	J:155856
Biological Process	GO:0048699	generation of neurons	IDA	J:62777
Biological Process	GO:0048699	generation of neurons	IMP	J:196947
Biological Process	GO:0030902	hindbrain development	IDA	J:62777
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0007399	nervous system development	IEA	J:60000
Biological Process	GO:0030182	neuron differentiation	IMP	J:119184
Biological Process	GO:0048663	neuron fate commitment	IDA	J:100997
Biological Process	GO:0031016	pancreas development	ISO	J:164563
Biological Process	GO:0031016	pancreas development	IMP	J:125691
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:116355
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:125691
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:158304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:197142
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:158304
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:120017
Biological Process	GO:0006355	regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:183714
Biological Process	GO:0006355	regulation of DNA-templated transcription	IMP	J:51571
Biological Process	GO:0061074	regulation of neural retina development	IMP	J:115271
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0010842	retina layer formation	IMP	J:115271
Biological Process	GO:0060042	retina morphogenesis in camera-type eye	IMP	J:119184
Biological Process	GO:0048384	retinoic acid receptor signaling pathway	IDA	J:62777
Biological Process	GO:0009888	tissue development	ISO	J:164563
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0006366	transcription by RNA polymerase II	IDA	J:197142
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:158304
Biological Process	GO:0006366	transcription by RNA polymerase II	IMP	J:158304