GO Annotations Graph

• Symbol: Eomes
• Name: eomesodermin
• ID: MGI:1201683

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:176969
Molecular Function	GO:0031490	chromatin DNA binding	IDA	J:266522
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	TAS	J:226614
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA	J:160495
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:190269
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:168146
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:190269
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:113146
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9754479
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756660
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756665
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756678
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9756684
Cellular Component	GO:0005634	nucleus	IDA	J:150768
Cellular Component	GO:0005634	nucleus	IDA	J:99440
Cellular Component	GO:0005634	nucleus	IDA	J:99440
Cellular Component	GO:0005634	nucleus	IDA	J:154112
Cellular Component	GO:0005634	nucleus	IDA	J:99440
Cellular Component	GO:0005634	nucleus	IDA	J:99440
Cellular Component	GO:0005634	nucleus	IDA	J:197573
Cellular Component	GO:0005634	nucleus	IDA	J:215584
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0048708	astrocyte differentiation	IMP	J:266522
Biological Process	GO:0001824	blastocyst development	IMP	J:98502
Biological Process	GO:0007420	brain development	ISO	J:164563
Biological Process	GO:0010002	cardioblast differentiation	IMP	J:176969
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	IDA	J:154842
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	ISO	J:164563
Biological Process	GO:0002302	CD8-positive, alpha-beta T cell differentiation involved in immune response	IBA	J:265628
Biological Process	GO:0030154	cell differentiation	IMP	J:98502
Biological Process	GO:0030154	cell differentiation	IMP	J:60897
Biological Process	GO:0060706	cell differentiation involved in embryonic placenta development	IMP	J:60897
Biological Process	GO:0021987	cerebral cortex development	IMP	J:266522
Biological Process	GO:0021895	cerebral cortex neuron differentiation	IDA	J:144650
Biological Process	GO:0021796	cerebral cortex regionalization	IMP	J:266522
Biological Process	GO:0021796	cerebral cortex regionalization	IMP	J:196080
Biological Process	GO:0006338	chromatin remodeling	IMP	J:266522
Biological Process	GO:0080111	DNA demethylation	IMP	J:266522
Biological Process	GO:0006306	DNA methylation	IMP	J:266522
Biological Process	GO:0001706	endoderm formation	IMP	J:131055
Biological Process	GO:0001706	endoderm formation	IMP	J:176969
Biological Process	GO:0001706	endoderm formation	IMP	J:168146
Biological Process	GO:0001714	endodermal cell fate specification	IBA	J:265628
Biological Process	GO:0001714	endodermal cell fate specification	IMP	J:168146
Biological Process	GO:0007369	gastrulation	IEA	J:60000
Biological Process	GO:0010467	gene expression	IMP	J:266522
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0001707	mesoderm formation	IBA	J:265628
Biological Process	GO:0001707	mesoderm formation	IMP	J:60897
Biological Process	GO:0060809	mesodermal to mesenchymal transition involved in gastrulation	IMP	J:131055
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:190269
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:190269
Biological Process	GO:0022008	neurogenesis	IMP	J:138764
Biological Process	GO:0030182	neuron differentiation	IMP	J:266522
Biological Process	GO:0030182	neuron differentiation	IMP	J:138764
Biological Process	GO:0001764	neuron migration	IMP	J:266522
Biological Process	GO:0021772	olfactory bulb development	IMP	J:148764
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:168146
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0010468	regulation of gene expression	IMP	J:168146
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:154112
Biological Process	GO:0035914	skeletal muscle cell differentiation	IMP	J:178918
Biological Process	GO:0019827	stem cell population maintenance	IMP	J:160495
Biological Process	GO:0001829	trophectodermal cell differentiation	IDA	J:104800
Biological Process	GO:0001829	trophectodermal cell differentiation	IGI	J:104800
Biological Process	GO:0032609	type II interferon production	IDA	J:160369