GO Annotations Graph

• Symbol: Terf2
• Name: telomeric repeat binding factor 2
• ID: MGI:1195972

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	IMP	J:43202
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0003691	double-stranded telomeric DNA binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0098505	G-rich strand telomeric DNA binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:198831
Molecular Function	GO:0005515	protein binding	IPI	J:163158
Molecular Function	GO:0005515	protein binding	IPI	J:163935
Molecular Function	GO:0005515	protein binding	IPI	J:219962
Molecular Function	GO:0005515	protein binding	IPI	J:158884
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	IPI	J:43202
Molecular Function	GO:0044877	protein-containing complex binding	IPI	J:125414
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	ISO	J:164563
Molecular Function	GO:0003720	telomerase activity	IBA	J:265628
Molecular Function	GO:0042162	telomeric DNA binding	IDA	J:199000
Molecular Function	GO:0042162	telomeric DNA binding	ISO	J:164563
Cellular Component	GO:0005694	chromosome	IEA	J:60000
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:199000
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:228117
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:123677
Cellular Component	GO:0000781	chromosome, telomeric region	IDA	J:105516
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:123677
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0000783	nuclear telomere cap complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912355
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0070187	shelterin complex	ISO	J:164563
Cellular Component	GO:0070187	shelterin complex	IBA	J:265628
Cellular Component	GO:0000782	telomere cap complex	IDA	J:239544
Biological Process	GO:0008089	anterograde axonal transport	IMP	J:228023
Biological Process	GO:0099088	axonal transport of messenger ribonucleoprotein complex	ISO	J:155856
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0001701	in utero embryonic development	IMP	J:105516
Biological Process	GO:1903770	negative regulation of beta-galactosidase activity	ISO	J:164563
Biological Process	GO:2000773	negative regulation of cellular senescence	ISO	J:164563
Biological Process	GO:1905778	negative regulation of exonuclease activity	ISO	J:164563
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:164563
Biological Process	GO:1904430	negative regulation of t-circle formation	ISO	J:164563
Biological Process	GO:1904354	negative regulation of telomere capping	ISO	J:164563
Biological Process	GO:0032205	negative regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0032208	negative regulation of telomere maintenance via recombination	ISO	J:164563
Biological Process	GO:0032208	negative regulation of telomere maintenance via recombination	IMP	J:240381
Biological Process	GO:0032208	negative regulation of telomere maintenance via recombination	IBA	J:265628
Biological Process	GO:0032211	negative regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:1904357	negative regulation of telomere maintenance via telomere lengthening	ISO	J:164563
Biological Process	GO:1905839	negative regulation of telomeric D-loop disassembly	ISO	J:164563
Biological Process	GO:1905839	negative regulation of telomeric D-loop disassembly	IBA	J:265628
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0032206	positive regulation of telomere maintenance	NAS	J:319993
Biological Process	GO:0032206	positive regulation of telomere maintenance	IDA	J:105516
Biological Process	GO:0032206	positive regulation of telomere maintenance	IMP	J:105516
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	IMP	J:163935
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	IMP	J:240381
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	ISO	J:164563
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	IBA	J:265628
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	IDA	J:105516
Biological Process	GO:0031848	protection from non-homologous end joining at telomere	IMP	J:105516
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	ISO	J:164563
Biological Process	GO:0070198	protein localization to chromosome, telomeric region	IBA	J:265628
Biological Process	GO:0032204	regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	ISO	J:164563
Biological Process	GO:0032210	regulation of telomere maintenance via telomerase	IBA	J:265628
Biological Process	GO:0016233	telomere capping	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	ISO	J:164563
Biological Process	GO:0000723	telomere maintenance	IDA	J:105516
Biological Process	GO:0000723	telomere maintenance	IMP	J:105516
Biological Process	GO:0000723	telomere maintenance	IMP	J:88560
Biological Process	GO:0061820	telomeric D-loop disassembly	ISO	J:164563
Biological Process	GO:0061820	telomeric D-loop disassembly	IBA	J:265628
Biological Process	GO:0031627	telomeric loop formation	ISO	J:164563
Biological Process	GO:0031627	telomeric loop formation	IMP	J:240381
Biological Process	GO:0031627	telomeric loop formation	IBA	J:265628