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Terf2 Gene Detail
Summary
  • Symbol
    Terf2
  • Name
    telomeric repeat binding factor 2
  • Synonyms
    TRF2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195972
    NCBI Gene: 21750
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:107796032-107823179 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 53.59 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    637 from dbSNP Build 142
  • Strain Annotations
    19
  • PCR
    1
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195972
 protein coding gene Chr8:107796032-107823180 (-)
129S1/SvImJ ENSMUSG00200014008
 protein coding gene Chr8:102077135-102104274 (-)
A/J ENSMUSG00195015726
 protein coding gene Chr8:102399523-102426668 (-)
AKR/J ENSMUSG00220014230
 protein coding gene Chr8:102538511-102565654 (-)
BALB/cJ ENSMUSG00180023436
 protein coding gene Chr8:102405302-102432444 (-)
C3H/HeJ ENSMUSG00175021962
 protein coding gene Chr8:102462325-102489463 (-)
C57BL/6NJ ENSMUSG00215031103
 protein coding gene Chr8:102075616-102102776 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031532
 protein coding gene Chr8:98194873-98220769 (-)
CAST/EiJ ENSTCUG00005032127
 protein coding gene Chr8:101831518-101858269 (-)
CBA/J ENSMUSG00210028621
 protein coding gene Chr8:102389659-102416799 (-)
DBA/2J ENSMUSG00185005599
 protein coding gene Chr8:108498392-108525531 (-)
FVB/NJ ENSMUSG00205012571
 protein coding gene Chr8:101373220-101400360 (-)
JF1/MsJ ENSUMUG00000005217
 protein coding gene Chr8:110831579-110858717 (-)
LP/J ENSMUSG00230031451
 protein coding gene Chr8:112178683-112205824 (-)
NOD/ShiLtJ ENSMUSG00190018541
 protein coding gene Chr8:102523881-102551020 (-)
NZO/HlLtJ ENSMUSG00225021302
 protein coding gene Chr8:115529270-115556408 (-)
PWK/PhJ ENSLUMG00010025417
 protein coding gene Chr8:102310603-102337816 (-)
SPRET/EiJ ENSMSPG00010038235
 protein coding gene Chr8:104377914-104404296 (-)
WSB/EiJ ENSIUOG00005027356
 protein coding gene Chr8:103208662-103235814 (-)



Homology
more
  • Human Ortholog
    TERF2, telomeric repeat binding factor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TERF2, telomeric repeat binding factor 2
  • Synonyms
    TRBF2, TRF2
  • Links
    NCBI Gene ID: 7014
    UniProt: Q15554

  • Chr Location
    16q22.1; chr16:69355464-69408571 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Terf2 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 5 alleles in 3 genetic backgrounds
    5 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    121
  • GO References
    25
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    700
  • Tissues
    51
  • cDNA Data
    12
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031921 Ensembl Gene Model | MGI Sequence Detail 27148 C57BL/6J ±  kb
    transcript ENSMUST00000068421 Ensembl | MGI Sequence Detail 2667 Not Applicable  
    polypeptide ENSMUSP00000068948 Ensembl | MGI Sequence Detail 541 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000016236 telomeric repeat-binding factor 2
      (term hierarchy)
    • InterPro Domains
      IPR009057 Homeodomain-like superfamily
      IPR017930 Myb domain
      IPR001005 SANT/Myb domain
      IPR013867 Telomere repeat-binding factor, dimerisation domain
      IPR036507 Telomere repeat-binding factor, dimerisation domain superfamily
      IPR017357 Telomeric repeat-binding factor 1/2
      IPR030657 Telomeric repeat-binding factor 2
      IPR031902 Telomeric repeat-binding factor 2, Rap1-binding domain
    • GlyGen
      O35144 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 16
      cDNA 13
      Primer pair 3
      Antibodies 2

      Microarray probesets 6
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 25
      Phenotypes 35
    • Earliest
      J:43202 Broccoli D, et al., Human telomeres contain two distinct Myb-related proteins, TRF1 and TRF2. Nat Genet. 1997 Oct;17(2):231-5
    • Latest
      J:388289 Ramadhiani R, et al., Endothelial cell senescence exacerbates pulmonary hypertension by inducing juxtacrine Notch signaling in smooth muscle cells. iScience. 2023 May 19;26(5):106662
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory