GO Annotations Graph

• Symbol: Bhlhe40
• Name: basic helix-loop-helix family, member e40
• ID: MGI:1097714

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043425	bHLH transcription factor binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:80553
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:178280
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:178280
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:211246
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:180463
Molecular Function	GO:0070888	E-box binding	IDA	J:180463
Molecular Function	GO:0070888	E-box binding	ISO	J:164563
Molecular Function	GO:0070888	E-box binding	IDA	J:79730
Molecular Function	GO:0070888	E-box binding	IDA	J:271702
Molecular Function	GO:0070888	E-box binding	IDA	J:178280
Molecular Function	GO:0043426	MRF binding	IDA	J:180463
Molecular Function	GO:0005515	protein binding	IPI	J:180463
Molecular Function	GO:0005515	protein binding	IPI	J:80553
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	ISO	J:164563
Molecular Function	GO:0046982	protein heterodimerization activity	ISO	J:164563
Molecular Function	GO:0042803	protein homodimerization activity	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA	J:178280
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IDA	J:180463
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0016604	nuclear body	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-879795
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:80553
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:137262
Biological Process	GO:0032922	circadian regulation of gene expression	IMP	J:271702
Biological Process	GO:0032922	circadian regulation of gene expression	ISO	J:164563
Biological Process	GO:0032922	circadian regulation of gene expression	IBA	J:265628
Biological Process	GO:0007623	circadian rhythm	IEP	J:211246
Biological Process	GO:0007623	circadian rhythm	ISO	J:164563
Biological Process	GO:0043153	entrainment of circadian clock by photoperiod	IMP	J:137262
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:271702
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:80553
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0042752	regulation of circadian rhythm	IMP	J:271702
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0009416	response to light stimulus	ISO	J:155856
Biological Process	GO:0048511	rhythmic process	IEA	J:60000