GO Annotations Graph

• Symbol: Htr2b
• Name: 5-hydroxytryptamine (serotonin) receptor 2B
• ID: MGI:109323

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

---

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

---

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:72247
Molecular Function	GO:0004930	G protein-coupled receptor activity	IEA	J:60000
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IDA	J:163130
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	IBA	J:265628
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	ISO	J:31112
Molecular Function	GO:0004993	G protein-coupled serotonin receptor activity	TAS	J:64067
Molecular Function	GO:0001965	G-protein alpha-subunit binding	ISO	J:164563
Molecular Function	GO:0001587	Gq/11-coupled serotonin receptor activity	ISO	J:164563
Molecular Function	GO:0005096	GTPase activator activity	IMP	J:39559
Molecular Function	GO:0030594	neurotransmitter receptor activity	IBA	J:265628
Molecular Function	GO:0051378	serotonin binding	IDA	J:163130
Molecular Function	GO:0051378	serotonin binding	ISO	J:155856
Molecular Function	GO:0051378	serotonin binding	ISO	J:164563
Molecular Function	GO:0051378	serotonin binding	ISO	J:31112
Cellular Component	GO:0005737	cytoplasm	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:163130
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0030425	dendrite	IBA	J:265628
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	IDA	J:163130
Cellular Component	GO:0098666	G protein-coupled serotonin receptor complex	ISO	J:164563
Cellular Component	GO:0016020	membrane	ISO	J:155856
Cellular Component	GO:0043005	neuron projection	IEA	J:60000
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:163130
Cellular Component	GO:0005886	plasma membrane	ISO	J:155856
Cellular Component	GO:0045202	synapse	IEA	J:60000
Biological Process	GO:0007202	activation of phospholipase C activity	ISO	J:164563
Biological Process	GO:0007610	behavior	IEA	J:60000
Biological Process	GO:0019722	calcium-mediated signaling	ISO	J:164563
Biological Process	GO:0003300	cardiac muscle hypertrophy	IMP	J:156435
Biological Process	GO:0071418	cellular response to amine stimulus	ISO	J:155856
Biological Process	GO:1904015	cellular response to serotonin	ISO	J:155856
Biological Process	GO:0071502	cellular response to temperature stimulus	IDA	J:163130
Biological Process	GO:0019934	cGMP-mediated signaling	ISO	J:164563
Biological Process	GO:0007268	chemical synaptic transmission	IBA	J:265628
Biological Process	GO:0048598	embryonic morphogenesis	IMP	J:40606
Biological Process	GO:0070371	ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:39559
Biological Process	GO:0070371	ERK1 and ERK2 cascade	IMP	J:161157
Biological Process	GO:0002031	G protein-coupled receptor internalization	IDA	J:163130
Biological Process	GO:0007186	G protein-coupled receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007187	G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA	J:265628
Biological Process	GO:0098664	G protein-coupled serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007507	heart development	IMP	J:64067
Biological Process	GO:0003007	heart morphogenesis	IMP	J:40606
Biological Process	GO:0014827	intestine smooth muscle contraction	ISO	J:164563
Biological Process	GO:0006874	intracellular calcium ion homeostasis	ISO	J:164563
Biological Process	GO:0034220	monoatomic ion transmembrane transport	ISO	J:155856
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:40606
Biological Process	GO:0010507	negative regulation of autophagy	ISO	J:164563
Biological Process	GO:0060548	negative regulation of cell death	ISO	J:164563
Biological Process	GO:0014033	neural crest cell differentiation	IMP	J:40606
Biological Process	GO:0001755	neural crest cell migration	IMP	J:40606
Biological Process	GO:0014065	phosphatidylinositol 3-kinase signaling	ISO	J:164563
Biological Process	GO:0007200	phospholipase C-activating G protein-coupled receptor signaling pathway	IBA	J:265628
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007208	phospholipase C-activating serotonin receptor signaling pathway	TAS	J:64067
Biological Process	GO:0016310	phosphorylation	ISO	J:164563
Biological Process	GO:0051781	positive regulation of cell division	IMP	J:39559
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	ISO	J:164563
Biological Process	GO:0001819	positive regulation of cytokine production	IMP	J:156435
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	IMP	J:162980
Biological Process	GO:0001938	positive regulation of endothelial cell proliferation	ISO	J:164563
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:0043406	positive regulation of MAP kinase activity	ISO	J:164563
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:164563
Biological Process	GO:0010513	positive regulation of phosphatidylinositol biosynthetic process	ISO	J:164563
Biological Process	GO:0070528	protein kinase C signaling	ISO	J:164563
Biological Process	GO:0007205	protein kinase C-activating G protein-coupled receptor signaling pathway	IMP	J:163130
Biological Process	GO:0050795	regulation of behavior	IMP	J:167209
Biological Process	GO:0050795	regulation of behavior	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	ISO	J:164563
Biological Process	GO:0051209	release of sequestered calcium ion into cytosol	IBA	J:265628
Biological Process	GO:0009410	response to xenobiotic stimulus	ISO	J:164563
Biological Process	GO:0007165	signal transduction	IEA	J:60000
Biological Process	GO:0006939	smooth muscle contraction	IEA	J:72247
Biological Process	GO:0042310	vasoconstriction	ISO	J:164563