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Htr2b Gene Detail
Summary
  • Symbol
    Htr2b
  • Name
    5-hydroxytryptamine (serotonin) receptor 2B
  • Synonyms
    5-HT2B
  • Feature Type
    protein coding gene
  • IDs
    MGI:109323
    NCBI Gene: 15559
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:86026748-86039692 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 43.94 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    318 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_109323
 protein coding gene Chr1:86025268-86043960 (-)
129S1/SvImJ ENSMUSG00200037164
 protein coding gene Chr1:83244144-83257087 (-)
A/J ENSMUSG00195030890
 protein coding gene Chr1:82816397-82829340 (-)
AKR/J ENSMUSG00220038893
 protein coding gene Chr1:82937961-82950905 (-)
BALB/cJ ENSMUSG00180015382
 protein coding gene Chr1:83113970-83126914 (-)
C3H/HeJ ENSMUSG00175001147
 protein coding gene Chr1:82995270-83008213 (-)
C57BL/6NJ ENSMUSG00215015087
 protein coding gene Chr1:82915707-82928651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014358
 protein coding gene Chr1:78601147-78612411 (-)
CAST/EiJ ENSTCUG00005007094
 protein coding gene Chr1:82567765-82580671 (-)
CBA/J ENSMUSG00210012339
 protein coding gene Chr1:82838266-82851210 (-)
DBA/2J ENSMUSG00185015867
 protein coding gene Chr1:87311204-87324155 (-)
FVB/NJ ENSMUSG00205027651
 protein coding gene Chr1:82251005-82263948 (-)
JF1/MsJ ENSUMUG00000006915
 protein coding gene Chr1:86087256-86100184 (-)
LP/J ENSMUSG00230017787
 protein coding gene Chr1:86590084-86603027 (-)
NOD/ShiLtJ ENSMUSG00190021234
 protein coding gene Chr1:82893375-82906322 (-)
NZO/HlLtJ ENSMUSG00225002269
 protein coding gene Chr1:90492897-90505840 (-)
PWK/PhJ ENSLUMG00010035163
 protein coding gene Chr1:82465001-82477899 (-)
SPRET/EiJ ENSMSPG00010040218
 protein coding gene Chr1:84470538-84482452 (-)
WSB/EiJ ENSIUOG00005037106
 protein coding gene Chr1:82495133-82508080 (-)



Homology
more
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR2B, 5-hydroxytryptamine receptor 2B
  • Synonyms
    5-HT(2B), 5-HT-2B, 5-HT2B
  • Links
    NCBI Gene ID: 3357
    UniProt: P41595

  • Chr Location
    2q37.1; chr2:231108230-231125080 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Htr2b mouse models; 2 with human HTR2B associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    41 phenotypes from 5 alleles in 6 genetic backgrounds
    57 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit a lack of cardiac trabeculae, ventricular hypoplasia due to impaired myocyte proliferation, and midgestational and neonatal lethality of variable severity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    878
  • Tissues
    171
  • cDNA Data
    6
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026228 Ensembl Gene Model | MGI Sequence Detail 12945 C57BL/6J ±  kb
    transcript ENSMUST00000027431 Ensembl | MGI Sequence Detail 2083 Not Applicable  
    polypeptide ENSMUSP00000027431 Ensembl | MGI Sequence Detail 479 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 2
      cDNA 7
      Primer pair 6
      Other 3
      Antibodies 6

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-38368, MGI:2138380, MGI:2138536
    References
    more
    • Summaries
      All 124
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 18
      Phenotypes 57
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:386418 Wang Q, et al., Commensal-driven serotonin production modulates in vivo delivery of synthetic and viral vectors. Science. 2026 Mar 19;391(6791):eadu7686
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory