GO Annotations Graph

• Symbol: Upf1
• Name: UPF1 RNA helicase and ATPase
• ID: MGI:107995

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0016887	ATP hydrolysis activity	ISO	J:164563
Molecular Function	GO:0003682	chromatin binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IEA	J:72247
Molecular Function	GO:0036121	double-stranded DNA helicase activity	ISO	J:164563
Molecular Function	GO:0004386	helicase activity	IEA	J:60000
Molecular Function	GO:0004386	helicase activity	IEA	J:72247
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:72247
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:247390
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	ISO	J:164563
Molecular Function	GO:0003723	RNA binding	IBA	J:265628
Molecular Function	GO:0003724	RNA helicase activity	ISO	J:164563
Molecular Function	GO:0003724	RNA helicase activity	IBA	J:265628
Molecular Function	GO:0042162	telomeric DNA binding	ISO	J:164563
Molecular Function	GO:0008270	zinc ion binding	IEA	J:72247
Cellular Component	GO:0000785	chromatin	ISO	J:164563
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	IBA	J:265628
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0005829	cytosol	TAS	Reactome:R-MMU-9014672
Cellular Component	GO:0035145	exon-exon junction complex	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0044530	supraspliceosomal complex	ISO	J:164563
Biological Process	GO:0061158	3'-UTR-mediated mRNA destabilization	ISO	J:164563
Biological Process	GO:0044770	cell cycle phase transition	ISO	J:164563
Biological Process	GO:0071347	cellular response to interleukin-1	ISO	J:164563
Biological Process	GO:0071222	cellular response to lipopolysaccharide	ISO	J:164563
Biological Process	GO:0032508	DNA duplex unwinding	ISO	J:164563
Biological Process	GO:0006281	DNA repair	ISO	J:164563
Biological Process	GO:0006260	DNA replication	ISO	J:164563
Biological Process	GO:0071044	histone mRNA catabolic process	ISO	J:164563
Biological Process	GO:0000956	nuclear-transcribed mRNA catabolic process	ISO	J:164563
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	ISO	J:164563
Biological Process	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IBA	J:265628
Biological Process	GO:0000294	nuclear-transcribed mRNA catabolic process, RNase MRP-dependent	ISO	J:164563
Biological Process	GO:0061014	positive regulation of mRNA catabolic process	ISO	J:164563
Biological Process	GO:0032204	regulation of telomere maintenance	ISO	J:164563
Biological Process	GO:0006449	regulation of translational termination	ISO	J:164563
Biological Process	GO:0032201	telomere maintenance via semi-conservative replication	ISO	J:164563