Adam8 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Adam8
a disintegrin and metallopeptidase domain 8
MGI:107825

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005509	calcium ion binding	IDA	J:80712
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:164288
Molecular Function	GO:0050839	cell adhesion molecule binding	ISO	J:164563
Molecular Function	GO:0050839	cell adhesion molecule binding	IPI	J:169801
Molecular Function	GO:0050839	cell adhesion molecule binding	IBA	J:265628
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0005178	integrin binding	TAS	J:172989
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004222	metalloendopeptidase activity	IBA	J:265628
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:89492
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:169801
Molecular Function	GO:0008237	metallopeptidase activity	ISO	J:164563
Molecular Function	GO:0008237	metallopeptidase activity	IDA	J:80712
Molecular Function	GO:0008233	peptidase activity	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:89492
Molecular Function	GO:0005515	protein binding	IPI	J:169801
Molecular Function	GO:0005515	protein binding	IPI	J:80712
Molecular Function	GO:0008270	zinc ion binding	IDA	J:169801
Molecular Function	GO:0008270	zinc ion binding	IDA	J:80712
Cellular Component	GO:0071133	alpha9-beta1 integrin-ADAM8 complex	IDA	J:128102
Cellular Component	GO:0009986	cell surface	ISO	J:164563
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0032127	dense core granule membrane	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0032010	phagolysosome	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	ISO	J:164563
Cellular Component	GO:0005886	plasma membrane	IDA	J:80712
Cellular Component	GO:0002102	podosome	ISO	J:164563
Cellular Component	GO:0002102	podosome	TAS	J:172958
Cellular Component	GO:0042581	specific granule	ISO	J:164563
Cellular Component	GO:0070820	tertiary granule	ISO	J:164563
Biological Process	GO:0001525	angiogenesis	IDA	J:172962
Biological Process	GO:0043534	blood vessel endothelial cell migration	NAS	J:172962
Biological Process	GO:0000902	cell morphogenesis	IMP	J:172936
Biological Process	GO:0000902	cell morphogenesis	IMP	J:172898
Biological Process	GO:0098609	cell-cell adhesion	IDA	J:80712
Biological Process	GO:0007160	cell-matrix adhesion	TAS	J:172898
Biological Process	GO:0071456	cellular response to hypoxia	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	ISO	J:164563
Biological Process	GO:0006954	inflammatory response	IBA	J:265628
Biological Process	GO:0002523	leukocyte migration involved in inflammatory response	IMP	J:172944
Biological Process	GO:0048247	lymphocyte chemotaxis	IDA	J:165123
Biological Process	GO:0061025	membrane fusion	TAS	J:172898
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IDA	J:89492
Biological Process	GO:2000399	negative regulation of thymocyte aggregation	NAS	J:165123
Biological Process	GO:0072675	osteoclast fusion	TAS	J:80712
Biological Process	GO:0002675	positive regulation of acute inflammatory response	IMP	J:173132
Biological Process	GO:0045780	positive regulation of bone resorption	IMP	J:172936
Biological Process	GO:0045780	positive regulation of bone resorption	IDA	J:172898
Biological Process	GO:0045785	positive regulation of cell adhesion	IDA	J:80712
Biological Process	GO:0002693	positive regulation of cellular extravasation	IMP	J:172944
Biological Process	GO:0002693	positive regulation of cellular extravasation	IBA	J:265628
Biological Process	GO:2000418	positive regulation of eosinophil migration	IMP	J:172944
Biological Process	GO:2000415	positive regulation of fibronectin-dependent thymocyte migration	IMP	J:165123
Biological Process	GO:0050729	positive regulation of inflammatory response	IDA	J:172958
Biological Process	GO:0045089	positive regulation of innate immune response	IDA	J:172936
Biological Process	GO:0043406	positive regulation of MAP kinase activity	IDA	J:172936
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IDA	J:89492
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	ISO	J:164563
Biological Process	GO:0051044	positive regulation of membrane protein ectodomain proteolysis	IBA	J:265628
Biological Process	GO:2000391	positive regulation of neutrophil extravasation	ISO	J:164563
Biological Process	GO:0051092	positive regulation of NF-kappaB transcription factor activity	IDA	J:172936
Biological Process	GO:0051897	positive regulation of protein kinase B signaling	IDA	J:172936
Biological Process	GO:0033089	positive regulation of T cell differentiation in thymus	IDA	J:165123
Biological Process	GO:2000406	positive regulation of T cell migration	IMP	J:172944
Biological Process	GO:0070245	positive regulation of thymocyte apoptotic process	IMP	J:165123
Biological Process	GO:2000309	positive regulation of tumor necrosis factor (ligand) superfamily member 11 production	IMP	J:172936
Biological Process	GO:0006508	proteolysis	IBA	J:265628
Biological Process	GO:0022407	regulation of cell-cell adhesion	ISO	J:164563
Biological Process	GO:0022407	regulation of cell-cell adhesion	IBA	J:265628
Biological Process	GO:0045670	regulation of osteoclast differentiation	NAS	J:174126
Biological Process	GO:0048729	tissue morphogenesis	TAS	J:172898

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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