Ptk2b GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Ptk2b
PTK2 protein tyrosine kinase 2 beta
MGI:104908

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0043423	3-phosphoinositide-dependent protein kinase binding	ISO	J:155856
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0004683	calmodulin-dependent protein kinase activity	ISO	J:155856
Molecular Function	GO:0019899	enzyme binding	ISO	J:155856
Molecular Function	GO:0016301	kinase activity	IEA	J:60000
Molecular Function	GO:0004972	NMDA glutamate receptor activity	ISO	J:155856
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	IDA	J:122285
Molecular Function	GO:0004715	non-membrane spanning protein tyrosine kinase activity	ISO	J:164563
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0005515	protein binding	IPI	J:89495
Molecular Function	GO:0005515	protein binding	IPI	J:231935
Molecular Function	GO:0005515	protein binding	IPI	J:180487
Molecular Function	GO:0005515	protein binding	IPI	J:180575
Molecular Function	GO:0005515	protein binding	IPI	J:230354
Molecular Function	GO:0005515	protein binding	IPI	J:216329
Molecular Function	GO:0005515	protein binding	IPI	J:67886
Molecular Function	GO:0005515	protein binding	IPI	J:79952
Molecular Function	GO:0004672	protein kinase activity	IDA	J:79952
Molecular Function	GO:0043621	protein self-association	ISO	J:164563
Molecular Function	GO:0004713	protein tyrosine kinase activity	IBA	J:265628
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0016740	transferase activity	IEA	J:60000
Molecular Function	GO:0031625	ubiquitin protein ligase binding	ISO	J:155856
Cellular Component	GO:0097440	apical dendrite	ISO	J:155856
Cellular Component	GO:0030424	axon	ISO	J:155856
Cellular Component	GO:0044297	cell body	ISO	J:155856
Cellular Component	GO:0005938	cell cortex	ISO	J:155856
Cellular Component	GO:0030054	cell junction	IEA	J:60000
Cellular Component	GO:0042995	cell projection	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005856	cytoskeleton	IEA	J:72247
Cellular Component	GO:0030425	dendrite	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	ISO	J:155856
Cellular Component	GO:0043197	dendritic spine	IBA	J:265628
Cellular Component	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane	IEA	J:72247
Cellular Component	GO:0005925	focal adhesion	ISO	J:164563
Cellular Component	GO:0005925	focal adhesion	ISO	J:155856
Cellular Component	GO:0005925	focal adhesion	IBA	J:265628
Cellular Component	GO:0098978	glutamatergic synapse	ISO	J:155856
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IMP	J:250330
Cellular Component	GO:0098978	glutamatergic synapse	IDA	J:250330
Cellular Component	GO:0030426	growth cone	ISO	J:155856
Cellular Component	GO:0030027	lamellipodium	ISO	J:164563
Cellular Component	GO:0016020	membrane	IEA	J:60000
Cellular Component	GO:0045121	membrane raft	ISO	J:155856
Cellular Component	GO:0043025	neuronal cell body	ISO	J:155856
Cellular Component	GO:0017146	NMDA selective glutamate receptor complex	ISO	J:155856
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	IDA	J:159965
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:216329
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:155856
Cellular Component	GO:0048471	perinuclear region of cytoplasm	ISO	J:164563
Cellular Component	GO:0048471	perinuclear region of cytoplasm	IDA	J:216329
Cellular Component	GO:0005886	plasma membrane	IEA	J:60000
Cellular Component	GO:0098794	postsynapse	ISO	J:155856
Cellular Component	GO:0014069	postsynaptic density	ISO	J:155856
Cellular Component	GO:0099092	postsynaptic density, intracellular component	ISO	J:155856
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:250330
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:250330
Cellular Component	GO:0099092	postsynaptic density, intracellular component	IDA	J:250330
Cellular Component	GO:0098793	presynapse	IDA	J:250330
Cellular Component	GO:0098793	presynapse	IDA	J:250330
Cellular Component	GO:0098793	presynapse	IDA	J:250330
Cellular Component	GO:0098685	Schaffer collateral - CA1 synapse	ISO	J:155856
Biological Process	GO:0007015	actin filament organization	ISO	J:155856
Biological Process	GO:0090630	activation of GTPase activity	ISO	J:155856
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:155856
Biological Process	GO:0042976	activation of Janus kinase activity	ISO	J:164563
Biological Process	GO:0002250	adaptive immune response	IEA	J:60000
Biological Process	GO:0001525	angiogenesis	ISO	J:155856
Biological Process	GO:0043534	blood vessel endothelial cell migration	ISO	J:155856
Biological Process	GO:0045453	bone resorption	IMP	J:89495
Biological Process	GO:0007155	cell adhesion	ISO	J:155856
Biological Process	GO:0007166	cell surface receptor signaling pathway	ISO	J:164563
Biological Process	GO:0006968	cellular defense response	ISO	J:155856
Biological Process	GO:0071498	cellular response to fluid shear stress	IMP	J:216329
Biological Process	GO:0071300	cellular response to retinoic acid	ISO	J:164563
Biological Process	GO:0070098	chemokine-mediated signaling pathway	IMP	J:99741
Biological Process	GO:0086100	endothelin receptor signaling pathway	ISO	J:164563
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	ISO	J:155856
Biological Process	GO:0007173	epidermal growth factor receptor signaling pathway	IBA	J:265628
Biological Process	GO:0048041	focal adhesion assembly	ISO	J:155856
Biological Process	GO:0002376	immune system process	IEA	J:60000
Biological Process	GO:0007229	integrin-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0035235	ionotropic glutamate receptor signaling pathway	ISO	J:155856
Biological Process	GO:0060292	long-term synaptic depression	ISO	J:155856
Biological Process	GO:0060291	long-term synaptic potentiation	ISO	J:155856
Biological Process	GO:0000165	MAPK cascade	ISO	J:155856
Biological Process	GO:0002315	marginal zone B cell differentiation	IMP	J:63286
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:164563
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:159965
Biological Process	GO:0030502	negative regulation of bone mineralization	IMP	J:122285
Biological Process	GO:0008285	negative regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0010656	negative regulation of muscle cell apoptotic process	ISO	J:155856
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	ISO	J:164563
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	ISO	J:155856
Biological Process	GO:0030279	negative regulation of ossification	ISO	J:155856
Biological Process	GO:0043267	negative regulation of potassium ion transport	ISO	J:164563
Biological Process	GO:0031175	neuron projection development	ISO	J:155856
Biological Process	GO:0001556	oocyte maturation	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:155856
Biological Process	GO:0038083	peptidyl-tyrosine autophosphorylation	ISO	J:164563
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	IDA	J:122285
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:155856
Biological Process	GO:0018108	peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0016310	phosphorylation	IEA	J:60000
Biological Process	GO:0030838	positive regulation of actin filament polymerization	ISO	J:164563
Biological Process	GO:0045766	positive regulation of angiogenesis	IMP	J:139849
Biological Process	GO:2000538	positive regulation of B cell chemotaxis	IMP	J:63286
Biological Process	GO:0030307	positive regulation of cell growth	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:155856
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:159965
Biological Process	GO:0008284	positive regulation of cell population proliferation	ISO	J:164563
Biological Process	GO:0001954	positive regulation of cell-matrix adhesion	ISO	J:164563
Biological Process	GO:0007204	positive regulation of cytosolic calcium ion concentration	ISO	J:155856
Biological Process	GO:2000573	positive regulation of DNA biosynthetic process	ISO	J:155856
Biological Process	GO:0010595	positive regulation of endothelial cell migration	ISO	J:164563
Biological Process	GO:0010595	positive regulation of endothelial cell migration	IMP	J:139849
Biological Process	GO:0070374	positive regulation of ERK1 and ERK2 cascade	ISO	J:164563
Biological Process	GO:2000463	positive regulation of excitatory postsynaptic potential	ISO	J:155856
Biological Process	GO:0046330	positive regulation of JNK cascade	ISO	J:164563
Biological Process	GO:0043507	positive regulation of JUN kinase activity	ISO	J:155856
Biological Process	GO:0010976	positive regulation of neuron projection development	ISO	J:164563
Biological Process	GO:0045429	positive regulation of nitric oxide biosynthetic process	ISO	J:155856
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	ISO	J:155856
Biological Process	GO:0051000	positive regulation of nitric-oxide synthase activity	IMP	J:139849
Biological Process	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	ISO	J:164563
Biological Process	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	IMP	J:99741
Biological Process	GO:0045860	positive regulation of protein kinase activity	ISO	J:164563
Biological Process	GO:0045860	positive regulation of protein kinase activity	IMP	J:139849
Biological Process	GO:0051247	positive regulation of protein metabolic process	ISO	J:155856
Biological Process	GO:2000379	positive regulation of reactive oxygen species metabolic process	ISO	J:155856
Biological Process	GO:0051968	positive regulation of synaptic transmission, glutamatergic	ISO	J:155856
Biological Process	GO:0045727	positive regulation of translation	ISO	J:155856
Biological Process	GO:2000060	positive regulation of ubiquitin-dependent protein catabolic process	IMP	J:159965
Biological Process	GO:0099170	postsynaptic modulation of chemical synaptic transmission	ISO	J:155856
Biological Process	GO:0006468	protein phosphorylation	IDA	J:79952
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	IMP	J:139849
Biological Process	GO:2000249	regulation of actin cytoskeleton reorganization	IMP	J:99741
Biological Process	GO:0045765	regulation of angiogenesis	IEA	J:72247
Biological Process	GO:0030500	regulation of bone mineralization	IEA	J:72247
Biological Process	GO:0050848	regulation of calcium-mediated signaling	IMP	J:139849
Biological Process	GO:0030155	regulation of cell adhesion	ISO	J:164563
Biological Process	GO:0030334	regulation of cell migration	IEA	J:72247
Biological Process	GO:0042127	regulation of cell population proliferation	IEA	J:72247
Biological Process	GO:0008360	regulation of cell shape	ISO	J:164563
Biological Process	GO:0008360	regulation of cell shape	IMP	J:99741
Biological Process	GO:0010752	regulation of cGMP-mediated signaling	IMP	J:139849
Biological Process	GO:2000114	regulation of establishment of cell polarity	IMP	J:99741
Biological Process	GO:0032960	regulation of inositol trisphosphate biosynthetic process	IMP	J:99741
Biological Process	GO:0002688	regulation of leukocyte chemotaxis	IEA	J:72247
Biological Process	GO:0010758	regulation of macrophage chemotaxis	IMP	J:99741
Biological Process	GO:0045428	regulation of nitric oxide biosynthetic process	IMP	J:139849
Biological Process	GO:2000310	regulation of NMDA receptor activity	ISO	J:155856
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IMP	J:250330
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IDA	J:250330
Biological Process	GO:0099151	regulation of postsynaptic density assembly	IDA	J:250330
Biological Process	GO:0051279	regulation of release of sequestered calcium ion into cytosol	IMP	J:99741
Biological Process	GO:2000058	regulation of ubiquitin-dependent protein catabolic process	ISO	J:164563
Biological Process	GO:0043157	response to cation stress	ISO	J:155856
Biological Process	GO:0042542	response to hydrogen peroxide	ISO	J:155856
Biological Process	GO:0002931	response to ischemia	ISO	J:155856
Biological Process	GO:0007172	signal complex assembly	IEA	J:72247
Biological Process	GO:0007165	signal transduction	IEA	J:72247
Biological Process	GO:0002040	sprouting angiogenesis	IMP	J:174314
Biological Process	GO:0043149	stress fiber assembly	ISO	J:155856
Biological Process	GO:0033209	tumor necrosis factor-mediated signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	ISO	J:164563
Biological Process	GO:0048010	vascular endothelial growth factor receptor signaling pathway	IMP	J:139849

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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