Hes1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Hes1
hes family bHLH transcription factor 1
MGI:104853

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	ISO	J:155856
Molecular Function	GO:0003677	DNA binding	IDA	J:89485
Molecular Function	GO:0003677	DNA binding	IDA	J:62626
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IDA	J:98892
Molecular Function	GO:0001217	DNA-binding transcription repressor activity	IDA	J:163127
Molecular Function	GO:0001227	DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA	J:175435
Molecular Function	GO:0070888	E-box binding	ISO	J:155856
Molecular Function	GO:0070888	E-box binding	IDA	J:62626
Molecular Function	GO:0070888	E-box binding	IBA	J:265628
Molecular Function	GO:0042826	histone deacetylase binding	ISO	J:164563
Molecular Function	GO:0043398	HLH domain binding	IDA	J:163127
Molecular Function	GO:0042802	identical protein binding	ISO	J:155856
Molecular Function	GO:0008432	JUN kinase binding	ISO	J:155856
Molecular Function	GO:0071820	N-box binding	IDA	J:62626
Molecular Function	GO:0071820	N-box binding	IDA	J:163127
Molecular Function	GO:0071820	N-box binding	ISO	J:155856
Molecular Function	GO:0071820	N-box binding	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:175195
Molecular Function	GO:0005515	protein binding	IPI	J:163127
Molecular Function	GO:0005515	protein binding	IPI	J:175435
Molecular Function	GO:0005515	protein binding	IPI	J:163127
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0042803	protein homodimerization activity	IDA	J:175435
Molecular Function	GO:0044877	protein-containing complex binding	ISO	J:155856
Molecular Function	GO:0051087	protein-folding chaperone binding	IDA	J:103764
Molecular Function	GO:0061629	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	J:62626
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:155856
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0001222	transcription corepressor binding	ISO	J:155856
Cellular Component	GO:0000785	chromatin	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IDA	J:95925
Cellular Component	GO:0005622	intracellular anatomical structure	IDA	J:106653
Cellular Component	GO:0016363	nuclear matrix	ISO	J:155856
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-2197575
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9008180
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-2065278
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-NUL-9013683
Cellular Component	GO:0005634	nucleus	IDA	J:175195
Cellular Component	GO:0005634	nucleus	IDA	J:82774
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:64088
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:95925
Cellular Component	GO:0005634	nucleus	IDA	J:114702
Cellular Component	GO:0005634	nucleus	IDA	J:195630
Cellular Component	GO:0032991	protein-containing complex	IDA	J:163127
Biological Process	GO:0021984	adenohypophysis development	IMP	J:143548
Biological Process	GO:0035881	amacrine cell differentiation	IMP	J:100591
Biological Process	GO:0009952	anterior/posterior pattern specification	IBA	J:265628
Biological Process	GO:0035909	aorta morphogenesis	IMP	J:160266
Biological Process	GO:0048844	artery morphogenesis	IMP	J:160266
Biological Process	GO:0035910	ascending aorta morphogenesis	IMP	J:151566
Biological Process	GO:0030509	BMP signaling pathway	IGI	J:139170
Biological Process	GO:0021870	Cajal-Retzius cell differentiation	IGI	J:139170
Biological Process	GO:0061309	cardiac neural crest cell development involved in outflow tract morphogenesis	IMP	J:151566
Biological Process	GO:0007155	cell adhesion	IGI	J:94391
Biological Process	GO:0045165	cell fate commitment	IMP	J:64088
Biological Process	GO:0001709	cell fate determination	IMP	J:70081
Biological Process	GO:0048469	cell maturation	IGI	J:94391
Biological Process	GO:0016477	cell migration	IGI	J:143548
Biological Process	GO:0048667	cell morphogenesis involved in neuron differentiation	IGI	J:71074
Biological Process	GO:0008283	cell population proliferation	IMP	J:100591
Biological Process	GO:0008283	cell population proliferation	IMP	J:100591
Biological Process	GO:0008283	cell population proliferation	IMP	J:121843
Biological Process	GO:0008283	cell population proliferation	IMP	J:100591
Biological Process	GO:1990090	cellular response to nerve growth factor stimulus	ISO	J:155856
Biological Process	GO:0090102	cochlea development	IGI	J:135642
Biological Process	GO:0090102	cochlea development	IMP	J:135642
Biological Process	GO:0072049	comma-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0061009	common bile duct development	IMP	J:151981
Biological Process	GO:0003143	embryonic heart tube morphogenesis	IMP	J:151566
Biological Process	GO:0035883	enteroendocrine cell differentiation	IMP	J:138261
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0090162	establishment of epithelial cell polarity	IGI	J:171468
Biological Process	GO:0021861	forebrain radial glial cell differentiation	ISO	J:155856
Biological Process	GO:0072012	glomerulus vasculature development	IEP	J:97734
Biological Process	GO:0035315	hair cell differentiation	ISO	J:155856
Biological Process	GO:0021575	hindbrain morphogenesis	IGI	J:71074
Biological Process	GO:0001701	in utero embryonic development	IGI	J:71074
Biological Process	GO:0002085	inhibition of neuroepithelial cell differentiation	IMP	J:64088
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0042491	inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060122	inner ear receptor cell stereocilium organization	IGI	J:171468
Biological Process	GO:0060716	labyrinthine layer blood vessel development	IMP	J:160266
Biological Process	GO:0046331	lateral inhibition	IMP	J:62024
Biological Process	GO:0001889	liver development	IMP	J:95098
Biological Process	GO:0030324	lung development	IMP	J:64088
Biological Process	GO:0072282	metanephric nephron tubule morphogenesis	IEP	J:93145
Biological Process	GO:0030901	midbrain development	IGI	J:71074
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis	IGI	J:71074
Biological Process	GO:1902870	negative regulation of amacrine cell differentiation	IMP	J:100591
Biological Process	GO:0090281	negative regulation of calcium ion import	ISO	J:155856
Biological Process	GO:0045596	negative regulation of cell differentiation	IMP	J:121843
Biological Process	GO:1905934	negative regulation of cell fate determination	IMP	J:70081
Biological Process	GO:0043433	negative regulation of DNA-binding transcription factor activity	IDA	J:62626
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	ISO	J:155856
Biological Process	GO:2000978	negative regulation of forebrain neuron differentiation	ISO	J:155856
Biological Process	GO:0010629	negative regulation of gene expression	ISO	J:155856
Biological Process	GO:0060253	negative regulation of glial cell proliferation	IDA	J:82774
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IMP	J:70081
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IMP	J:64679
Biological Process	GO:0045608	negative regulation of inner ear auditory receptor cell differentiation	IGI	J:171468
Biological Process	GO:2000981	negative regulation of inner ear receptor cell differentiation	IMP	J:108846
Biological Process	GO:0050768	negative regulation of neurogenesis	ISO	J:155856
Biological Process	GO:0045665	negative regulation of neuron differentiation	IBA	J:265628
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:139170
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:94391
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:100591
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:54662
Biological Process	GO:0045665	negative regulation of neuron differentiation	IMP	J:64088
Biological Process	GO:0045665	negative regulation of neuron differentiation	IGI	J:54662
Biological Process	GO:0010977	negative regulation of neuron projection development	ISO	J:155856
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	IDA	J:82774
Biological Process	GO:0048715	negative regulation of oligodendrocyte differentiation	ISO	J:155856
Biological Process	GO:2000227	negative regulation of pancreatic A cell differentiation	IMP	J:59312
Biological Process	GO:2000974	negative regulation of pro-B cell differentiation	ISO	J:164563
Biological Process	GO:2000737	negative regulation of stem cell differentiation	ISO	J:164563
Biological Process	GO:0061106	negative regulation of stomach neuroendocrine cell differentiation	IMP	J:138261
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:151566
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:62626
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:160266
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:175435
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	ISO	J:155856
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:98892
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:98892
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:98892
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:103764
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IMP	J:98892
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:68229
Biological Process	GO:0021915	neural tube development	IGI	J:62024
Biological Process	GO:0021915	neural tube development	IGI	J:71074
Biological Process	GO:0061101	neuroendocrine cell differentiation	IMP	J:64088
Biological Process	GO:0030182	neuron differentiation	IMP	J:100591
Biological Process	GO:0030182	neuron differentiation	IGI	J:94391
Biological Process	GO:0030182	neuron differentiation	IMP	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0030182	neuron differentiation	IGI	J:54662
Biological Process	GO:0097150	neuronal stem cell population maintenance	ISO	J:155856
Biological Process	GO:0097150	neuronal stem cell population maintenance	IMP	J:175113
Biological Process	GO:0007219	Notch signaling pathway	NAS	J:93145
Biological Process	GO:0007219	Notch signaling pathway	ISO	J:164563
Biological Process	GO:0007219	Notch signaling pathway	TAS	J:97734
Biological Process	GO:0007219	Notch signaling pathway	IBA	J:265628
Biological Process	GO:0007219	Notch signaling pathway	IDA	J:218237
Biological Process	GO:0021557	oculomotor nerve development	IGI	J:71074
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:160266
Biological Process	GO:0003151	outflow tract morphogenesis	IMP	J:151566
Biological Process	GO:0031016	pancreas development	IMP	J:151981
Biological Process	GO:0003310	pancreatic A cell differentiation	IMP	J:59312
Biological Process	GO:0007389	pattern specification process	IMP	J:135642
Biological Process	GO:0007389	pattern specification process	IGI	J:135642
Biological Process	GO:0061626	pharyngeal arch artery morphogenesis	IMP	J:160266
Biological Process	GO:0021983	pituitary gland development	IMP	J:112960
Biological Process	GO:0021983	pituitary gland development	IGI	J:121843
Biological Process	GO:0021983	pituitary gland development	IMP	J:121843
Biological Process	GO:0048711	positive regulation of astrocyte differentiation	IDA	J:82774
Biological Process	GO:0030513	positive regulation of BMP signaling pathway	IGI	J:139170
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:160266
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:121843
Biological Process	GO:0008284	positive regulation of cell population proliferation	IMP	J:100591
Biological Process	GO:0043388	positive regulation of DNA binding	IDA	J:175195
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:108846
Biological Process	GO:0010628	positive regulation of gene expression	ISO	J:155856
Biological Process	GO:0045687	positive regulation of glial cell differentiation	ISO	J:155856
Biological Process	GO:0045977	positive regulation of mitotic cell cycle, embryonic	IMP	J:151566
Biological Process	GO:0045747	positive regulation of Notch signaling pathway	IMP	J:108846
Biological Process	GO:0046427	positive regulation of receptor signaling pathway via JAK-STAT	IDA	J:175195
Biological Process	GO:0042102	positive regulation of T cell proliferation	IMP	J:98892
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:160266
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IMP	J:151566
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:71074
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:71074
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:71074
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:71074
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:144373
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:71074
Biological Process	GO:0042531	positive regulation of tyrosine phosphorylation of STAT protein	IDA	J:175195
Biological Process	GO:0065003	protein-containing complex assembly	IDA	J:175195
Biological Process	GO:0006355	regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IGI	J:171468
Biological Process	GO:0045598	regulation of fat cell differentiation	IMP	J:89916
Biological Process	GO:0050767	regulation of neurogenesis	IBA	J:265628
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:62024
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0050767	regulation of neurogenesis	IGI	J:144373
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:62024
Biological Process	GO:0043254	regulation of protein-containing complex assembly	ISO	J:155856
Biological Process	GO:0046425	regulation of receptor signaling pathway via JAK-STAT	IDA	J:175195
Biological Process	GO:0003266	regulation of secondary heart field cardioblast proliferation	IMP	J:151566
Biological Process	GO:0048505	regulation of timing of cell differentiation	IMP	J:30431
Biological Process	GO:0048505	regulation of timing of cell differentiation	IMP	J:112960
Biological Process	GO:0060164	regulation of timing of neuron differentiation	IMP	J:30431
Biological Process	GO:0060164	regulation of timing of neuron differentiation	IGI	J:71074
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IGI	J:162236
Biological Process	GO:0072141	renal interstitial fibroblast development	IEP	J:97734
Biological Process	GO:0072050	S-shaped body morphogenesis	IEP	J:97734
Biological Process	GO:0007224	smoothened signaling pathway	IDA	J:146198
Biological Process	GO:0035019	somatic stem cell population maintenance	IMP	J:59312
Biological Process	GO:0061102	stomach neuroendocrine cell differentiation	IMP	J:138261
Biological Process	GO:0042098	T cell proliferation	IMP	J:98892
Biological Process	GO:0021537	telencephalon development	IGI	J:139170
Biological Process	GO:0021537	telencephalon development	IMP	J:144373
Biological Process	GO:0048538	thymus development	IMP	J:160266
Biological Process	GO:0021558	trochlear nerve development	IGI	J:71074
Biological Process	GO:0060675	ureteric bud morphogenesis	IEP	J:97734
Biological Process	GO:0097084	vascular associated smooth muscle cell development	IMP	J:160266
Biological Process	GO:0003281	ventricular septum development	IMP	J:160266
Biological Process	GO:0060412	ventricular septum morphogenesis	IMP	J:151566

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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