GO Annotations Graph

• Symbol: Twist2
• Name: twist basic helix-loop-helix transcription factor 2
• ID: MGI:104685

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IDA	J:124396
Molecular Function	GO:0003677	DNA binding	IEA	J:60000
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:29655
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:165982
Molecular Function	GO:0005515	protein binding	IPI	J:87173
Molecular Function	GO:0005515	protein binding	IPI	J:144706
Molecular Function	GO:0046983	protein dimerization activity	IEA	J:72247
Molecular Function	GO:0019904	protein domain specific binding	IPI	J:90056
Molecular Function	GO:0000977	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0008134	transcription factor binding	IDA	J:87173
Cellular Component	GO:0005737	cytoplasm	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-9007869
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:29655
Biological Process	GO:0030154	cell differentiation	IEA	J:60000
Biological Process	GO:0008283	cell population proliferation	IMP	J:144706
Biological Process	GO:0008283	cell population proliferation	IMP	J:144706
Biological Process	GO:0061303	cornea development in camera-type eye	IMP	J:171395
Biological Process	GO:0032502	developmental process	IBA	J:265628
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:90056
Biological Process	GO:0060325	face morphogenesis	IMP	J:169191
Biological Process	GO:0060325	face morphogenesis	IMP	J:171395
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:171395
Biological Process	GO:0043616	keratinocyte proliferation	IMP	J:171395
Biological Process	GO:0010934	macrophage cytokine production	IMP	J:124396
Biological Process	GO:0010934	macrophage cytokine production	IGI	J:124396
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0030099	myeloid cell differentiation	IMP	J:144706
Biological Process	GO:0043066	negative regulation of apoptotic process	ISO	J:155856
Biological Process	GO:0008285	negative regulation of cell population proliferation	IMP	J:144706
Biological Process	GO:0043392	negative regulation of DNA binding	IDA	J:87173
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IDA	J:29655
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IGI	J:124396
Biological Process	GO:0010936	negative regulation of macrophage cytokine production	IMP	J:124396
Biological Process	GO:0044092	negative regulation of molecular function	IDA	J:90056
Biological Process	GO:0045638	negative regulation of myeloid cell differentiation	IMP	J:144706
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	ISO	J:164563
Biological Process	GO:0045668	negative regulation of osteoblast differentiation	IMP	J:90056
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:124396
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144706
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:87173
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:87173
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:87173
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:87173
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IGI	J:144706
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IGI	J:124396
Biological Process	GO:0032720	negative regulation of tumor necrosis factor production	IMP	J:124396
Biological Process	GO:0001649	osteoblast differentiation	IMP	J:90056
Biological Process	GO:0030335	positive regulation of cell migration	ISO	J:164563
Biological Process	GO:0010838	positive regulation of keratinocyte proliferation	IMP	J:171395
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IDA	J:29655
Biological Process	GO:0032640	tumor necrosis factor production	IMP	J:124396
Biological Process	GO:0032640	tumor necrosis factor production	IGI	J:124396