Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables DNA-binding transcription factor activity; chromatin binding activity; and protein domain specific binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within several processes, including face morphogenesis; negative regulation of cell differentiation; and negative regulation of macromolecule biosynthetic process. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; branchial arch; embryo mesenchyme; genitourinary system; and integumental system. Human ortholog(s) of this gene implicated in Barber-Say syndrome and ablepharon macrostomia syndrome. Orthologous to human TWIST2 (twist family bHLH transcription factor 2).