GO Annotations Graph

• Symbol: Pms2
• Name: PMS1 homolog2, mismatch repair system component
• ID: MGI:104288

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0005524	ATP binding	IEA	J:60000
Molecular Function	GO:0005524	ATP binding	IEA	J:72247
Molecular Function	GO:0016887	ATP hydrolysis activity	IBA	J:265628
Molecular Function	GO:0140664	ATP-dependent DNA damage sensor activity	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0030983	mismatched DNA binding	IEA	J:72247
Molecular Function	GO:0032407	MutSalpha complex binding	ISO	J:164563
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0000166	nucleotide binding	IEA	J:60000
Molecular Function	GO:0032138	single base insertion or deletion binding	ISO	J:164563
Molecular Function	GO:0003697	single-stranded DNA binding	ISO	J:164563
Cellular Component	GO:0005829	cytosol	ISO	J:164563
Cellular Component	GO:0032300	mismatch repair complex	IEA	J:72247
Cellular Component	GO:0032389	MutLalpha complex	IBA	J:265628
Cellular Component	GO:0032389	MutLalpha complex	IDA	J:111285
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IMP	J:102704
Biological Process	GO:0006974	DNA damage response	IGI	J:102704
Biological Process	GO:0006281	DNA repair	IMP	J:94712
Biological Process	GO:0051321	meiotic cell cycle	TAS	J:62204
Biological Process	GO:0006298	mismatch repair	IBA	J:265628
Biological Process	GO:0006298	mismatch repair	TAS	J:62204
Biological Process	GO:0006298	mismatch repair	IGI	J:102704
Biological Process	GO:0006298	mismatch repair	IMP	J:68922
Biological Process	GO:0006298	mismatch repair	IMP	J:102704
Biological Process	GO:0006298	mismatch repair	IMP	J:115827
Biological Process	GO:0006298	mismatch repair	IMP	J:55724
Biological Process	GO:0006298	mismatch repair	IMP	J:115296
Biological Process	GO:0006298	mismatch repair	IMP	J:46382
Biological Process	GO:0006298	mismatch repair	IMP	J:192085
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	IGI	J:56764
Biological Process	GO:0048298	positive regulation of isotype switching to IgA isotypes	IMP	J:56764
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IMP	J:56764
Biological Process	GO:0048304	positive regulation of isotype switching to IgG isotypes	IGI	J:56764
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:48081
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IBA	J:265628
Biological Process	GO:0016446	somatic hypermutation of immunoglobulin genes	IMP	J:115296
Biological Process	GO:0016447	somatic recombination of immunoglobulin gene segments	IMP	J:124827