Six1 GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

Six1
sine oculis-related homeobox 1
MGI:102780

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003682	chromatin binding	IGI	J:147237
Molecular Function	GO:0003682	chromatin binding	IGI	J:147237
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0001228	DNA-binding transcription activator activity, RNA polymerase II-specific	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	ISO	J:164563
Molecular Function	GO:0003700	DNA-binding transcription factor activity	IDA	J:103002
Molecular Function	GO:0000981	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA	J:265628
Molecular Function	GO:0005515	protein binding	IPI	J:124751
Molecular Function	GO:0005515	protein binding	IPI	J:147237
Molecular Function	GO:0005515	protein binding	IPI	J:90664
Molecular Function	GO:0005515	protein binding	IPI	J:212814
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:157941
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0005515	protein binding	IPI	J:184001
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA	J:265628
Molecular Function	GO:0043565	sequence-specific DNA binding	ISO	J:164563
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:51236
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:51236
Molecular Function	GO:0043565	sequence-specific DNA binding	IDA	J:119948
Molecular Function	GO:1990837	sequence-specific double-stranded DNA binding	ISO	J:164563
Molecular Function	GO:0000976	transcription cis-regulatory region binding	ISO	J:164563
Molecular Function	GO:0001223	transcription coactivator binding	ISO	J:155856
Cellular Component	GO:0005737	cytoplasm	IEA	J:60000
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	IDA	J:86619
Cellular Component	GO:0005634	nucleus	IDA	J:51236
Cellular Component	GO:0005667	transcription regulator complex	IBA	J:265628
Cellular Component	GO:0005667	transcription regulator complex	IDA	J:86619
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:147237
Cellular Component	GO:0005667	transcription regulator complex	IPI	J:147237
Biological Process	GO:0048856	anatomical structure development	IGI	J:108725
Biological Process	GO:0048856	anatomical structure development	IGI	J:108725
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0035909	aorta morphogenesis	IGI	J:172023
Biological Process	GO:0006915	apoptotic process	IEA	J:60000
Biological Process	GO:0001658	branching involved in ureteric bud morphogenesis	IGI	J:83432
Biological Process	GO:1905243	cellular response to 3,3',5-triiodo-L-thyronine	ISO	J:155856
Biological Process	GO:0090103	cochlea morphogenesis	IMP	J:84974
Biological Process	GO:0048701	embryonic cranial skeleton morphogenesis	IGI	J:163483
Biological Process	GO:0048704	embryonic skeletal system morphogenesis	IGI	J:98519
Biological Process	GO:0086100	endothelin receptor signaling pathway	IMP	J:241567
Biological Process	GO:0030855	epithelial cell differentiation	IMP	J:108725
Biological Process	GO:0021610	facial nerve morphogenesis	IMP	J:84974
Biological Process	GO:0061197	fungiform papilla morphogenesis	IMP	J:190431
Biological Process	GO:0010467	gene expression	IMP	J:241567
Biological Process	GO:0048699	generation of neurons	IMP	J:114468
Biological Process	GO:0048839	inner ear development	IMP	J:149467
Biological Process	GO:0042472	inner ear morphogenesis	IGI	J:98519
Biological Process	GO:0001822	kidney development	IMP	J:119570
Biological Process	GO:0072198	mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:0072198	mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:0072172	mesonephric tubule formation	IMP	J:172983
Biological Process	GO:0072075	metanephric mesenchyme development	IMP	J:172983
Biological Process	GO:0042474	middle ear morphogenesis	IMP	J:84974
Biological Process	GO:0007275	multicellular organism development	IEA	J:60000
Biological Process	GO:0051451	myoblast migration	IGI	J:98519
Biological Process	GO:0051451	myoblast migration	IGI	J:98519
Biological Process	GO:0051450	myoblast proliferation	IGI	J:157941
Biological Process	GO:0061055	myotome development	IMP	J:98519
Biological Process	GO:0061055	myotome development	IMP	J:156719
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:98519
Biological Process	GO:0043066	negative regulation of apoptotic process	IMP	J:145187
Biological Process	GO:0045892	negative regulation of DNA-templated transcription	IEA	J:72247
Biological Process	GO:0043524	negative regulation of neuron apoptotic process	IMP	J:114468
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II	IDA	J:171473
Biological Process	GO:0014033	neural crest cell differentiation	IGI	J:241567
Biological Process	GO:0022008	neurogenesis	IMP	J:145187
Biological Process	GO:0048665	neuron fate specification	IGI	J:184001
Biological Process	GO:0007219	Notch signaling pathway	IMP	J:241567
Biological Process	GO:0030910	olfactory placode formation	IMP	J:145187
Biological Process	GO:0001759	organ induction	IMP	J:83432
Biological Process	GO:0071599	otic vesicle development	IMP	J:119574
Biological Process	GO:0071599	otic vesicle development	IGI	J:184001
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0003151	outflow tract morphogenesis	IGI	J:172023
Biological Process	GO:0007389	pattern specification process	IMP	J:119574
Biological Process	GO:0007389	pattern specification process	IGI	J:108725
Biological Process	GO:0060037	pharyngeal system development	IMP	J:108725
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0060037	pharyngeal system development	IGI	J:172023
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IMP	J:172983
Biological Process	GO:0090190	positive regulation of branching involved in ureteric bud morphogenesis	IGI	J:171473
Biological Process	GO:0090336	positive regulation of brown fat cell differentiation	IMP	J:237490
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:122815
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IMP	J:172983
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	ISO	J:164563
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:165033
Biological Process	GO:0045893	positive regulation of DNA-templated transcription	IDA	J:156719
Biological Process	GO:2000729	positive regulation of mesenchymal cell proliferation involved in ureter development	IGI	J:157941
Biological Process	GO:2000288	positive regulation of myoblast proliferation	IGI	J:157941
Biological Process	GO:0072513	positive regulation of secondary heart field cardioblast proliferation	IGI	J:172023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	ISO	J:164563
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:184001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:184001
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IGI	J:172023
Biological Process	GO:0045944	positive regulation of transcription by RNA polymerase II	IDA	J:103002
Biological Process	GO:0072107	positive regulation of ureteric bud formation	IMP	J:172983
Biological Process	GO:0034504	protein localization to nucleus	ISO	J:164563
Biological Process	GO:0072095	regulation of branch elongation involved in ureteric bud branching	IMP	J:172983
Biological Process	GO:0006355	regulation of DNA-templated transcription	IDA	J:86619
Biological Process	GO:0050678	regulation of epithelial cell proliferation	IMP	J:145187
Biological Process	GO:0010468	regulation of gene expression	IGI	J:178379
Biological Process	GO:0045664	regulation of neuron differentiation	IMP	J:94396
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0045664	regulation of neuron differentiation	IGI	J:184001
Biological Process	GO:0032880	regulation of protein localization	IGI	J:178379
Biological Process	GO:2001014	regulation of skeletal muscle cell differentiation	IDA	J:165033
Biological Process	GO:0014857	regulation of skeletal muscle cell proliferation	IBA	J:265628
Biological Process	GO:0014842	regulation of skeletal muscle satellite cell proliferation	IDA	J:165033
Biological Process	GO:0008582	regulation of synaptic assembly at neuromuscular junction	IGI	J:178379
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II	IBA	J:265628
Biological Process	GO:0007605	sensory perception of sound	IMP	J:84974
Biological Process	GO:0048741	skeletal muscle fiber development	IBA	J:265628
Biological Process	GO:0007519	skeletal muscle tissue development	IMP	J:122815
Biological Process	GO:0007519	skeletal muscle tissue development	IGI	J:98519
Biological Process	GO:0048705	skeletal system morphogenesis	IMP	J:84974
Biological Process	GO:0007382	specification of segmental identity, maxillary segment	IMP	J:241567
Biological Process	GO:0048538	thymus development	IMP	J:108725
Biological Process	GO:0048538	thymus development	IGI	J:108725
Biological Process	GO:0030878	thyroid gland development	IMP	J:108725
Biological Process	GO:0043586	tongue development	IMP	J:190431
Biological Process	GO:0061551	trigeminal ganglion development	IMP	J:114468
Biological Process	GO:0072193	ureter smooth muscle cell differentiation	IMP	J:157941
Biological Process	GO:0001657	ureteric bud development	IGI	J:100569
Biological Process	GO:0001657	ureteric bud development	IGI	J:100569
Biological Process	GO:0001657	ureteric bud development	IMP	J:83432

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/07/2024 MGI 6.23