GO Annotations Graph

• Symbol: Fen1
• Name: flap structure specific endonuclease 1
• ID: MGI:102779

GO annotations

A table of the annotations represented in this image is provided below.

• Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
• Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
• Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
• Graph generated Fri Mar 10 20:53:16 2023.

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Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP Inferred from experiment

HMP Inferred from high throughput mutant phenotype

HGI Inferred from high throughput genetic interaction

HDA Inferred from high throughput direct assay

HEP Inferred from high throughput expression pattern

IDA Inferred from direct assay

IEP Inferred from expression pattern

IGI Inferred from genetic interaction

IMP Inferred from mutant phenotype

IPI Inferred from physical interaction

Homology:

IAS Inferred from ancestral sequence

IBA Inferred from biological aspect of ancestor

IBD Inferred from biological aspect of descendant

IKR Inferred from key residues

IMR Inferred from missing residues

IRD Inferred from rapid divergence

ISA Inferred from sequence alignment

ISM Inferred from sequence model

ISO Inferred from sequence orthology

ISS Inferred from sequence or structural similarity

Automated:

IEA Inferred from electronic annotation

RCA Reviewed computational analysis

Other:

IC Inferred by curator

NAS Non-traceable author statement

ND No biological data available

TAS Traceable author statement

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Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0008409	5'-3' exonuclease activity	ISO	J:164563
Molecular Function	GO:0008409	5'-3' exonuclease activity	IBA	J:265628
Molecular Function	GO:0017108	5'-flap endonuclease activity	ISO	J:164563
Molecular Function	GO:0017108	5'-flap endonuclease activity	IBA	J:265628
Molecular Function	GO:0003824	catalytic activity	IEA	J:72247
Molecular Function	GO:0003677	DNA binding	ISO	J:164563
Molecular Function	GO:0003677	DNA binding	IDA	J:78267
Molecular Function	GO:0004519	endonuclease activity	IEA	J:60000
Molecular Function	GO:0004527	exonuclease activity	IDA	J:78267
Molecular Function	GO:0048256	flap endonuclease activity	ISO	J:164563
Molecular Function	GO:0048256	flap endonuclease activity	IDA	J:78267
Molecular Function	GO:0016787	hydrolase activity	IEA	J:60000
Molecular Function	GO:0016788	hydrolase activity, acting on ester bonds	IEA	J:72247
Molecular Function	GO:0000287	magnesium ion binding	IBA	J:265628
Molecular Function	GO:0000287	magnesium ion binding	IDA	J:78267
Molecular Function	GO:0030145	manganese ion binding	IBA	J:265628
Molecular Function	GO:0030145	manganese ion binding	IDA	J:78267
Molecular Function	GO:0046872	metal ion binding	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:60000
Molecular Function	GO:0004518	nuclease activity	IEA	J:72247
Molecular Function	GO:0004523	RNA-DNA hybrid ribonuclease activity	ISO	J:164563
Molecular Function	GO:0004523	RNA-DNA hybrid ribonuclease activity	IBA	J:265628
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0005739	mitochondrion	ISO	J:164563
Cellular Component	GO:0005730	nucleolus	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IBA	J:265628
Cellular Component	GO:0005634	nucleus	TAS	J:78267
Cellular Component	GO:0032991	protein-containing complex	ISO	J:218220
Biological Process	GO:0006974	DNA damage response	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IMP	J:84556
Biological Process	GO:0006260	DNA replication	IMP	J:84556
Biological Process	GO:0043137	DNA replication, removal of RNA primer	ISO	J:164563
Biological Process	GO:0007613	memory	ISO	J:155856
Biological Process	GO:0090305	nucleic acid phosphodiester bond hydrolysis	ISO	J:164563
Biological Process	GO:0045876	positive regulation of sister chromatid cohesion	ISO	J:164563