H2ax GO Annotations Graph

GO Annotations Graph

Symbol
Name
ID

H2ax
H2A.X variant histone
MGI:102688

GO annotations (Text View) (Tabular View)

A table of the annotations represented in this image is provided below.

Gray arrows indicate "is_a"; Blue arrows indicate "part_of"; Black arrows indicate "regulates"; Green arrows indicate "positively_regulates"; Red arrows indicate "negatively_regulates"
Experimental annotations are indicated by darker-colored nodes; other annotations by lighter-colored nodes
Clicking on any node links to the MGI GO browser and information on all genes annotated to the term or its subterms.
Graph generated Fri Mar 10 20:53:16 2023.

Gene Ontology Evidence Code Abbreviations:

Experimental:

EXP: Inferred from experiment
HMP: Inferred from high throughput mutant phenotype
HGI: Inferred from high throughput genetic interaction
HDA: Inferred from high throughput direct assay
HEP: Inferred from high throughput expression pattern
IDA: Inferred from direct assay
IEP: Inferred from expression pattern
IGI: Inferred from genetic interaction
IMP: Inferred from mutant phenotype
IPI: Inferred from physical interaction

Homology:

IAS: Inferred from ancestral sequence
IBA: Inferred from biological aspect of ancestor
IBD: Inferred from biological aspect of descendant
IKR: Inferred from key residues
IMR: Inferred from missing residues
IRD: Inferred from rapid divergence
ISA: Inferred from sequence alignment
ISM: Inferred from sequence model
ISO: Inferred from sequence orthology
ISS: Inferred from sequence or structural similarity

Automated:

IEA: Inferred from electronic annotation
RCA: Reviewed computational analysis

Other:

IC: Inferred by curator
NAS: Non-traceable author statement
ND: No biological data available
TAS: Traceable author statement

Category	GO ID	Classification Term	Evidence	Reference
Molecular Function	GO:0003684	damaged DNA binding	IDA	J:76360
Molecular Function	GO:0003677	DNA binding	IBA	J:265628
Molecular Function	GO:0019899	enzyme binding	ISO	J:164563
Molecular Function	GO:0042393	histone binding	ISO	J:164563
Molecular Function	GO:0005515	protein binding	IPI	J:143888
Molecular Function	GO:0005515	protein binding	IPI	J:200413
Molecular Function	GO:0005515	protein binding	IPI	J:159292
Molecular Function	GO:0005515	protein binding	IPI	J:222892
Molecular Function	GO:0046982	protein heterodimerization activity	IEA	J:72247
Molecular Function	GO:0030527	structural constituent of chromatin	IEA	J:72247
Cellular Component	GO:0005813	centrosome	ISO	J:164563
Cellular Component	GO:0000785	chromatin	IDA	J:135578
Cellular Component	GO:0000785	chromatin	IDA	J:95995
Cellular Component	GO:0000785	chromatin	IDA	J:236226
Cellular Component	GO:0000785	chromatin	IDA	J:140402
Cellular Component	GO:0000785	chromatin	IDA	J:123677
Cellular Component	GO:0000785	chromatin	IDA	J:76360
Cellular Component	GO:0005694	chromosome	IDA	J:268520
Cellular Component	GO:0005694	chromosome	IDA	J:297328
Cellular Component	GO:0005694	chromosome	IDA	J:285969
Cellular Component	GO:0005694	chromosome	IDA	J:192634
Cellular Component	GO:0000781	chromosome, telomeric region	ISO	J:164563
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:185266
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:161203
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:227337
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:195265
Cellular Component	GO:0000794	condensed nuclear chromosome	IDA	J:182264
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:138760
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:284005
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:152950
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:123677
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:87152
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:130019
Cellular Component	GO:0001673	male germ cell nucleus	IDA	J:87152
Cellular Component	GO:0016607	nuclear speck	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	ISO	J:164563
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912421
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912423
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912431
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912449
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912462
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912468
Cellular Component	GO:0005654	nucleoplasm	TAS	Reactome:R-MMU-912487
Cellular Component	GO:0000786	nucleosome	IEA	J:60000
Cellular Component	GO:0000786	nucleosome	IEA	J:72247
Cellular Component	GO:0005634	nucleus	ISO	J:164563
Cellular Component	GO:0005634	nucleus	ISO	J:155856
Cellular Component	GO:0005634	nucleus	IDA	J:159292
Cellular Component	GO:0005634	nucleus	IDA	J:196753
Cellular Component	GO:0005634	nucleus	ISO	J:89037
Cellular Component	GO:0005634	nucleus	ISO	J:94951
Cellular Component	GO:0005634	nucleus	IDA	J:160813
Cellular Component	GO:0005634	nucleus	IDA	J:179634
Cellular Component	GO:0005634	nucleus	IDA	J:178645
Cellular Component	GO:0005657	replication fork	IDA	J:92518
Cellular Component	GO:0090734	site of DNA damage	ISO	J:164563
Cellular Component	GO:0035861	site of double-strand break	IDA	J:192409
Cellular Component	GO:0035861	site of double-strand break	ISO	J:73065
Cellular Component	GO:0035861	site of double-strand break	IDA	J:194119
Cellular Component	GO:0001741	XY body	IDA	J:224007
Cellular Component	GO:0001741	XY body	IDA	J:130361
Cellular Component	GO:0001741	XY body	IDA	J:222892
Cellular Component	GO:0001741	XY body	IDA	J:239544
Cellular Component	GO:0001741	XY body	IDA	J:199766
Cellular Component	GO:0001741	XY body	IDA	J:163018
Cellular Component	GO:0001741	XY body	IDA	J:284005
Cellular Component	GO:0001741	XY body	IDA	J:143556
Cellular Component	GO:0001741	XY body	IDA	J:173639
Cellular Component	GO:0001741	XY body	IDA	J:194119
Cellular Component	GO:0001741	XY body	IDA	J:131722
Cellular Component	GO:0001741	XY body	IDA	J:226405
Cellular Component	GO:0001741	XY body	IDA	J:192409
Cellular Component	GO:0001741	XY body	IDA	J:200772
Biological Process	GO:0007049	cell cycle	IEA	J:60000
Biological Process	GO:0071480	cellular response to gamma radiation	ISO	J:155856
Biological Process	GO:0006974	DNA damage response	ISO	J:164563
Biological Process	GO:0006974	DNA damage response	IBA	J:265628
Biological Process	GO:0006310	DNA recombination	IEA	J:60000
Biological Process	GO:0006281	DNA repair	IDA	J:92518
Biological Process	GO:0006281	DNA repair	IMP	J:76360
Biological Process	GO:0000724	double-strand break repair via homologous recombination	IMP	J:76360
Biological Process	GO:0051321	meiotic cell cycle	IEA	J:60000
Biological Process	GO:0007283	spermatogenesis	IMP	J:76360

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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