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Hnrnpk Gene Detail
Summary
  • Symbol
    Hnrnpk
  • Name
    heterogeneous nuclear ribonucleoprotein K
  • Synonyms
    hnRNPK, Hnrpk, KBBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99894
    NCBI Gene: 15387
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:58538956-58551157 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 31.04 cM, cytoband B2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    22 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99894
 protein coding gene Chr13:58538946-58551157 (-)
129S1/SvImJ MGP_129S1SvImJ_G0020633
 protein coding gene Chr13:58032607-58042717 (-)
A/J MGP_AJ_G0020587
 protein coding gene Chr13:55877050-55890416 (-)
AKR/J MGP_AKRJ_G0020565
 protein coding gene Chr13:57539508-57552686 (-)
BALB/cJ MGP_BALBcJ_G0020583
 protein coding gene Chr13:56128836-56148994 (-)
C3H/HeJ MGP_C3HHeJ_G0020382
 protein coding gene Chr13:57346622-57360113 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021017
 protein coding gene Chr13:59813608-59826076 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018599
 protein coding gene Chr13:53770110-53781518 (-)
CAST/EiJ MGP_CASTEiJ_G0019896
 protein coding gene Chr13:57479970-57492434 (-)
CBA/J MGP_CBAJ_G0020342
 protein coding gene Chr13:62057646-62075226 (-)
DBA/2J MGP_DBA2J_G0020465
 protein coding gene Chr13:55425319-55440270 (-)
FVB/NJ MGP_FVBNJ_G0020444
 protein coding gene Chr13:54905214-54917258 (-)
LP/J MGP_LPJ_G0020541
 protein coding gene Chr13:58301255-58315289 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020473
 protein coding gene Chr13:61423012-61434727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021060
 protein coding gene Chr13:57143890-57156660 (-)
PWK/PhJ MGP_PWKPhJ_G0019652
 protein coding gene Chr13:55435080-55448135 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019479
 protein coding gene Chr13:56053910-56065338 (-)
WSB/EiJ MGP_WSBEiJ_G0019958
 protein coding gene Chr13:57578951-57589297 (-)



Homology
more
  • Human Ortholog
    HNRNPK, heterogeneous nuclear ribonucleoprotein K
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HNRNPK, heterogeneous nuclear ribonucleoprotein K
  • Synonyms
    AUKS, CSBP, HNRPK, TUNP
  • Links
    NCBI Gene ID: 3190
    neXtProt AC: NX_P61978
    UniProt: P61978

  • Chr Location
    9q21.32; chr9:83968083-83980782 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human HNRNPK associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a conditional allele activated in male germ cells exhibit small testes, reduced body size, meiotic arrest at prophase, increased male germ cell apoptosis, and infertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    81
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    752
  • Tissues
    38
  • cDNA Data
    23
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000021546 Ensembl Gene Model | MGI Sequence Detail 12202 C57BL/6J ±  kb
    transcript ENSMUST00000116403 Ensembl | MGI Sequence Detail 2970 Not Applicable  
    polypeptide ENSMUSP00000112104 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 24
      Primer pair 2
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16689
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 14
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:329220 Chen Y, et al., Hnrnpk maintains chondrocytes survival and function during growth plate development via regulating Hif1alpha-glycolysis axis. Cell Death Dis. 2022 Sep 20;13(9):803
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    01/17/2023
    MGI 6.22     		The Jackson Laboratory