Ppm1a MGI Mouse Gene Detail - MGI:99878 - protein phosphatase 1A, magnesium dependent, alpha isoform

Symbol

Ppm1a
Name

protein phosphatase 1A, magnesium dependent, alpha isoform
Synonyms

2310003C21Rik, 2900017D14Rik, MMPa-2, MPPa-1, Mpp alpha

Feature Type

protein coding gene
IDs

MGI:99878
NCBI Gene: 19042
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr12:72804231-72846593 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 12, 30.26 cM, cytoband C3
Mapping Data

3 experiments

SNPs within 2kb

178 from dbSNP Build 142
Strain Annotations

17

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99878	protein coding gene	Chr12:72804229-72846593 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019829	protein coding gene	Chr12:72608283-72650400 (+)
A/J	MGP_AJ_G0019787	protein coding gene	Chr12:69915375-69949576 (+)
AKR/J	MGP_AKRJ_G0019762	protein coding gene	Chr12:72029614-72065959 (+)
BALB/cJ	MGP_BALBcJ_G0019767	protein coding gene	Chr12:70390899-70424370 (+)
C3H/HeJ	MGP_C3HHeJ_G0019572	protein coding gene	Chr12:72456667-72494578 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0020219	protein coding gene	Chr12:74887500-74924905 (+)
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0019124	protein coding gene	Chr12:67230894-67272846 (+)
CBA/J	MGP_CBAJ_G0019542	protein coding gene	Chr12:77714968-77748626 (+)
DBA/2J	MGP_DBA2J_G0019658	protein coding gene	Chr12:69801391-69835447 (+)
FVB/NJ	MGP_FVBNJ_G0019645	protein coding gene	Chr12:68658963-68693763 (+)
LP/J	MGP_LPJ_G0019730	protein coding gene	Chr12:72649823-72691749 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019684	protein coding gene	Chr12:80872199-80921549 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0020254	protein coding gene	Chr12:71497885-71538430 (+)
PWK/PhJ	MGP_PWKPhJ_G0018889	protein coding gene	Chr12:64096674-64131605 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018684	protein coding gene	Chr12:65910653-65952698 (+)
WSB/EiJ	MGP_WSBEiJ_G0019175	protein coding gene	Chr12:72100209-72137891 (+)

Human Ortholog

PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PPM1A, protein phosphatase, Mg2+/Mn2+ dependent 1A
Synonyms

PP2CA, PP2Calpha, PP2C-ALPHA
Links

HGNC:9275

NCBI Gene ID: 5494

neXtProt AC: NX_P35813

UniProt: P35813
Chr Location

14q23.1; chr14:60245750-60299087 (+) GRCh38

MGI Vertebrate Homology

Ppm1a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: PPM1A
Gene Tree

Ppm1a

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Phenotype Summary

13 phenotypes from 4 alleles in 4 genetic backgrounds
3 phenotypes from multigenic genotypes
3 images
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

43
Chemically induced (other)

1
Endonuclease-mediated

2
Gene trapped

30
Targeted

10
Genomic Mutations

1 involving Ppm1a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

23 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit delayed wound healing, delayed re-epithelialization, and decreased keratinocyte migration.

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All GO Annotations

45
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

790
Tissues

25
cDNA Data

20
Literature Summary

5

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ppm1a

ZFIN ppm1aa, ppm1ab

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All Sequences

90
RefSeq

9
UniProt

7
CCDS

CCDS25970.1

Ensembl

ENSMUSG00000021096 (Evidence)
NCBI Gene

19042

			Length	Strain/Species	Flank
genomic	19042	NCBI Gene Model \| MGI Sequence Detail	42363	C57BL/6J	± kb
transcript	NM_008910	RefSeq \| MGI Sequence Detail	2789	C57BL/6
polypeptide	P49443	UniProt \| EBI \| MGI Sequence Detail	382	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000013090 protein phosphatase 1A

(term hierarchy)
EC

3.1.3.16
InterPro Domains

IPR036580 Phosphatase 2C, C-terminal domain superfamily

IPR000222 PPM-type phosphatase, divalent cation binding

IPR001932 PPM-type phosphatase-like domain

IPR036457 PPM-type phosphatase-like domain superfamily

IPR015655 Protein phosphatase 2C

IPR012911 Protein serine/threonine phosphatase 2C, C-terminal

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All nucleic 21

cDNA 21

Microarray probesets 14

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MGD-MRK-16669, MGI:1916736, MGI:1920167, MGI:2144816, MGI:2144943

Summaries

All 64

Developmental Gene Expression 5

Gene Ontology 13

Phenotypes 19
Earliest

J:19652 Kato S, et al., The cDNA sequence encoding mouse Mg2+ -dependent protein phosphatase alpha. Gene. 1994 Aug 5;145(2):311-2
Latest

J:306991 Zhou R, et al., The protein phosphatase PPM1A dephosphorylates and activates YAP to govern mammalian intestinal and liver regeneration. PLoS Biol. 2021 Feb;19(2):e3001122

TSS for Ppm1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr113759	Chr12:72804156-72804184 (+)	-61 bp
Tssr113760	Chr12:72807295-72807303 (+)	3,068 bp
Tssr113761	Chr12:72807903-72807914 (+)	3,678 bp
Tssr113762	Chr12:72807991-72808039 (+)	3,784 bp
Tssr113763	Chr12:72808041-72808090 (+)	3,835 bp
Tssr113764	Chr12:72812029-72812031 (+)	7,799 bp
Tssr113765	Chr12:72839067-72839069 (+)	34,837 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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