Epha3 MGI Mouse Gene Detail - MGI:99612

Symbol

Epha3
Name

Eph receptor A3
Synonyms

Cek4, End3, Hek, Hek4, Mek4, Tyro4

Feature Type

protein coding gene
IDs

MGI:99612
NCBI Gene: 13837
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr16:63363897-63684538 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 16, 36.49 cM
Mapping Data

4 experiments

SNPs within 2kb

9255 from dbSNP Build 142
Strain Annotations

27

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99612	protein coding gene	Chr16:63363895-63684538 (-)
129S1/SvImJ	ENSMUSGG00200054671	protein coding gene	Chr16:60418495-60459454 (-)
129S1/SvImJ	ENSMUSG00200021157	protein coding gene	Chr16:60575543-60663416 (-)
A/J	ENSMUSGG00195055227	protein coding gene	Chr16:60012543-60053516 (-)
A/J	ENSMUSG00195024878	protein coding gene	Chr16:60169625-60257512 (-)
AKR/J	ENSMUSG00220019083	protein coding gene	Chr16:60659333-60748514 (-)
AKR/J	ENSMUSGG00220054701	protein coding gene	Chr16:60480505-60523064 (-)
BALB/cJ	ENSMUSGG00180055014	protein coding gene	Chr16:60172457-60213423 (-)
BALB/cJ	ENSMUSG00180022719	protein coding gene	Chr16:60329527-60417409 (-)
C3H/HeJ	ENSMUSGG00175054736	protein coding gene	Chr16:60452586-60493545 (-)
C3H/HeJ	ENSMUSG00175016367	protein coding gene	Chr16:60609617-60697492 (-)
C57BL/6NJ	ENSMUSG00215020676	protein coding gene	Chr16:60423754-60512942 (-)
C57BL/6NJ	ENSMUSGG00215055519	protein coding gene	Chr16:60256346-60298907 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020859	protein coding gene	Chr16:59437406-59741994 (-)
CAST/EiJ	no annotation
CBA/J	ENSMUSG00210019529	protein coding gene	Chr16:60575848-60665000 (-)
CBA/J	ENSMUSGG00210054968	protein coding gene	Chr16:60411045-60453628 (-)
DBA/2J	ENSMUSGG00185057822	protein coding gene	Chr16:60349865-60390828 (-)
DBA/2J	ENSMUSG00185024753	protein coding gene	Chr16:60506931-60594816 (-)
FVB/NJ	ENSMUSGG00205054400	protein coding gene	Chr16:60140318-60182882 (-)
FVB/NJ	ENSMUSG00205009848	protein coding gene	Chr16:60305114-60394295 (-)
JF1/MsJ	no annotation
LP/J	ENSMUSGG00230055681	protein coding gene	Chr16:62909376-62950338 (-)
LP/J	ENSMUSG00230006947	protein coding gene	Chr16:63066441-63154318 (-)
NOD/ShiLtJ	ENSMUSGG00190054952	protein coding gene	Chr16:60395751-60438314 (-)
NOD/ShiLtJ	ENSMUSG00190007157	protein coding gene	Chr16:60560474-60649653 (-)
NZO/HlLtJ	ENSMUSG00225035863	protein coding gene	Chr16:66308961-66398136 (-)
NZO/HlLtJ	ENSMUSGG00225055155	protein coding gene	Chr16:66144214-66186776 (-)
PWK/PhJ	no annotation
SPRET/EiJ	ENSMSPG00010002040	protein coding gene	Chr16:60805152-61122162 (-)
WSB/EiJ	no annotation

Human Ortholog

EPHA3, EPH receptor A3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

EPHA3, EPH receptor A3
Synonyms

EK4, ETK, ETK1, HEK, HEK4, TYRO4
Links

HGNC:3387

NCBI Gene ID: 2042

UniProt: P29320
Chr Location

3p11.1; chr3:89107522-89482437 (+) GRCh38

MGI Vertebrate Homology

Epha3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: EPHA3
Protein SuperFamily

TyrPK_ephrin_receptor
Gene Tree

Epha3

Diseases

1 with human EPHA3 associations

				Human Disease	Mouse Models
				pancreatic cancer IDs pancreatic cancer DOID:1793 DOID:14356 DOID:1797 DOID:3588 DOID:9859 ICD10CM:C25.0 ICD10CM:C25.1 ICD10CM:C25.2 ICD9CM:157.0 ICD9CM:157.1 ICD9CM:157.2 ICD9CM:157.8 KEGG:05212 MESH:D010190 NCI:C194089 NCI:C194090 NCI:C194091 NCI:C3305 ORDO:1333 ORDO:217074 UMLS_CUI:C0030297 UMLS_CUI:C0153458 UMLS_CUI:C0153459 UMLS_CUI:C0153460 UMLS_CUI:C0153463

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

33 phenotypes from 2 alleles in 2 genetic backgrounds
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Endonuclease-mediated

5
Gene trapped

2
Targeted

3
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

79 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for disruptions in this gene usually die within 48 hours of birth of cardiac failure. Survivors develop normally with no indications of cardiac abnormalities.

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All GO Annotations

65
GO References

18

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1493
Tissues

398
cDNA Data

90
Literature Summary

97

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA EPHA3

ZFIN epha3

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All Sequences

69
RefSeq

4
UniProt

9
CCDS

CCDS28264.1, CCDS88948.1

Ensembl

ENSMUSG00000052504 (Evidence)
NCBI Gene

13837

			Length	Strain/Species	Flank
genomic	ENSMUSG00000052504	Ensembl Gene Model \| MGI Sequence Detail	320642	C57BL/6J	± kb
transcript	ENSMUST00000064405	Ensembl \| MGI Sequence Detail	5663	Not Applicable
polypeptide	ENSMUSP00000066554	Ensembl \| MGI Sequence Detail	984	Not Applicable

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UniProt

9 Sequences
Protein Ontology

PR:000007123 ephrin type-A receptor 3

(term hierarchy)
EC

2.7.10.1
InterPro Domains

IPR061283 Ephrin, cysteine rich domain

IPR001090 Ephrin, ligand binding domain

IPR016257 Ephrin receptor type-A /type-B

IPR050449 Ephrin receptor tyrosine kinases

IPR027936 Ephrin, transmembrane domain

IPR034266 Ephrin type-A receptor 3, ligand binding domain

IPR003961 Fibronectin type III

IPR036116 Fibronectin type III superfamily

IPR008979 Galactose-binding-like domain superfamily

IPR009030 Growth factor receptor cysteine-rich domain superfamily

IPR013783 Immunoglobulin-like fold

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain

IPR001660 Sterile alpha motif domain

IPR013761 Sterile alpha motif/pointed domain superfamily

IPR008266 Tyrosine-protein kinase, active site

IPR020635 Tyrosine-protein kinase, catalytic domain

IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like

IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
GlyGen

P29319 5 sites, 2 N-linked glycans (2 sites)

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All nucleic 116

Genomic 1

cDNA 93

Primer pair 14

Other 8

Antibodies 3

Microarray probesets 6

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MGD-MRK-16397, MGI:2146641, MGI:2662731

Summaries

All 171

Developmental Gene Expression 97

Gene Ontology 18

Phenotypes 17
Earliest

J:17817 Sajjadi FG, et al., Identification of a new eph-related receptor tyrosine kinase gene from mouse and chicken that is developmentally regulated and encodes at least two forms of the receptor. New Biol. 1991 Aug;3(8):769-78
Latest

J:385781 Tang T, et al., Ribosomal Profiling of the Geniculate Ganglion Identifies the Receptor ALK as Critical for the Development and Maintenance of Oral Sensory Neurons. J Neurosci. 2026 Apr 8;46(14)

TSS for Epha3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr141675	Chr16:63684477-63684545 (-)	27 bp
Tssr141674	Chr16:63684460-63684476 (-)	70 bp
Tssr141673	Chr16:63684426-63684435 (-)	107 bp
Tssr141672	Chr16:63578813-63578815 (-)	105,724 bp
Tssr141671	Chr16:63420918-63420919 (-)	263,619 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24