About   Help   FAQ
Pde4a Gene Detail
Summary
  • Symbol
    Pde4a
  • Name
    phosphodiesterase 4A, cAMP specific
  • Synonyms
    D9Ertd60e, Dpde2, dunce
  • Feature Type
    protein coding gene
  • IDs
    MGI:99558
    NCBI Gene: 18577
  • Alliance
    gene page
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:21077010-21124544 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 7.73 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    115 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99558
 protein coding gene Chr9:21076998-21124544 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034443
 protein coding gene Chr9:18354271-18405897 (+)
A/J MGP_AJ_G0034421
 protein coding gene Chr9:18048223-18098375 (+)
AKR/J MGP_AKRJ_G0034348
 protein coding gene Chr9:18376535-18423929 (+)
BALB/cJ MGP_BALBcJ_G0034412
 protein coding gene Chr9:17941824-17989548 (+)
C3H/HeJ MGP_C3HHeJ_G0034124
 protein coding gene Chr9:18680284-18731468 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034933
 protein coding gene Chr9:19095160-19147194 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031863
 protein coding gene Chr9:17175707-17223857 (+)
CAST/EiJ MGP_CASTEiJ_G0033447
 protein coding gene Chr9:18504604-18573039 (+)
CBA/J MGP_CBAJ_G0034097
 protein coding gene Chr9:19811024-19863050 (+)
DBA/2J MGP_DBA2J_G0034256
 protein coding gene Chr9:18025959-18073681 (+)
FVB/NJ MGP_FVBNJ_G0034199
 protein coding gene Chr9:17544124-17595637 (+)
LP/J MGP_LPJ_G0034341
 protein coding gene Chr9:18527901-18576664 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034242
 protein coding gene Chr9:21418826-21472212 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034953
 protein coding gene Chr9:18328679-18380366 (+)
PWK/PhJ MGP_PWKPhJ_G0033153
 protein coding gene Chr9:18001539-18064928 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032987
 protein coding gene Chr9:18387243-18447948 (+)
WSB/EiJ MGP_WSBEiJ_G0033562
 protein coding gene Chr9:18054062-18104263 (+)



Homology
more
  • Human Ortholog
    PDE4A, phosphodiesterase 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDE4A, phosphodiesterase 4A
  • Synonyms
    DPDE2, PDE4, PDE46
  • Links
    NCBI Gene ID: 5141
    neXtProt AC: NX_P27815
    UniProt: P27815

  • Chr Location
    19p13.2; chr19:10416773-10469631 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Homozygous null mice have a normal phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    853
  • Tissues
    147
  • cDNA Data
    31
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032177 Ensembl Gene Model | MGI Sequence Detail 47535 C57BL/6J ±  kb
transcript ENSMUST00000039413 Ensembl | MGI Sequence Detail 4653 Not Applicable  
polypeptide ENSMUSP00000037025 Ensembl | MGI Sequence Detail 844 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000012472 3',5'-cyclic-AMP phosphodiesterase 4A
    (term hierarchy)
  • EC
    3.1.4.-, 3.1.4.53
  • InterPro Domains
    IPR023088 3'5'-cyclic nucleotide phosphodiesterase
    IPR002073 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
    IPR036971 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily
    IPR023174 3'5'-cyclic nucleotide phosphodiesterase, conserved site
    IPR003607 HD/PDEase domain
    IPR040844 Phosphodiesterase 4 upstream conserved regions (UCR)
Molecular
Reagents
less
  • All nucleic 36
    cDNA 32
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-16336, MGI:1098742
References
more
  • Summaries
    All 66
    Developmental Gene Expression 6
    Gene Ontology 11
    Phenotypes 19
  • Earliest
    J:18405 Milatovich A, et al., Chromosome localizations of genes for five cAMP-specific phosphodiesterases in man and mouse. Somat Cell Mol Genet. 1994 Mar;20(2):75-86
  • Latest
    J:320373 Boyd A, et al., Assessment of PDE4 Inhibitor-Induced Hypothermia as a Correlate of Nausea in Mice. Biology (Basel). 2021 Dec 20;10(12)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory