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Cckbr Gene Detail
Summary
  • Symbol
    Cckbr
  • Name
    cholecystokinin B receptor
  • Synonyms
    CCK2/gastrin, CCK2R, CCK-B/gastrin receptor, CCKR-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99479
    NCBI Gene: 12426
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:105075201-105085546 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 7, 55.86 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    339 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99479
protein coding gene Chr7:105074938-105120105 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032752
protein coding gene Chr7:108672341-108719722 (+)
A/J MGP_AJ_G0032732
protein coding gene Chr7:105832650-105877651 (+)
AKR/J MGP_AKRJ_G0032665
protein coding gene Chr7:108601017-108650145 (+)
BALB/cJ MGP_BALBcJ_G0032738
protein coding gene Chr7:105549233-105594505 (+)
C3H/HeJ MGP_C3HHeJ_G0032447
protein coding gene Chr7:108697519-108743358 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033243
protein coding gene Chr7:113009888-113058597 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030227
protein coding gene Chr7:107809216-107855702 (+)
CAST/EiJ MGP_CASTEiJ_G0031777
protein coding gene Chr7:100519739-100571997 (+)
CBA/J MGP_CBAJ_G0032421
protein coding gene Chr7:116769788-116820549 (+)
DBA/2J MGP_DBA2J_G0032574
protein coding gene Chr7:104104512-104149887 (+)
FVB/NJ MGP_FVBNJ_G0032527
protein coding gene Chr7:103910169-103956939 (+)
LP/J MGP_LPJ_G0032665
protein coding gene Chr7:110074283-110121610 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032559
protein coding gene Chr7:118377763-118427916 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033264
protein coding gene Chr7:107659177-107707506 (+)
PWK/PhJ MGP_PWKPhJ_G0031490
protein coding gene Chr7:97036395-97083673 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031339
protein coding gene Chr7:94765061-94814616 (+)
WSB/EiJ MGP_WSBEiJ_G0031894
protein coding gene Chr7:108291300-108339144 (+)



Homology
more
  • Human Ortholog
    CCKBR, cholecystokinin B receptor
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCKBR, cholecystokinin B receptor
  • Synonyms
    CCK-2R, CCK2R, CCK-B, GASR
  • Links
    NCBI Gene ID: 887
    neXtProt AC: NX_P32239
    UniProt: P32239

  • Chr Location
    11p15.4; chr11:6259806-6272127 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human CCKBR associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    37 phenotypes from 3 alleles in 6 genetic backgrounds
    8 phenotypes from multigenic genotypes
    65 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Nullizygous mice show gastic mucoca defects, high gastic pH and hypergastrenemia. Homozygotes for a null allele also exhibit higher energy intake and expenditure, less susceptibility to endotoxin shock, altered pain and mechanical sensitivity, and behavioral changes to isolation and addictive drugs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12426 NCBI Gene Model | MGI Sequence Detail 10346 C57BL/6J ±  kb
    transcript NR_178082 RefSeq | MGI Sequence Detail 2314 ZRU/MplStud  
    polypeptide P56481 UniProt | EBI | MGI Sequence Detail 453 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 2
      cDNA 16
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16253
    References
    more
    • Summaries
      All 117
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 65
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    09/24/2024
    MGI 6.24
    The Jackson Laboratory