Arrb1 MGI Mouse Gene Detail - MGI:99473

Symbol

Arrb1
Name

arrestin, beta 1
Synonyms

1200006I17Rik, beta-arrestin1

Feature Type

protein coding gene
IDs

MGI:99473
NCBI Gene: 109689
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr7:99184673-99255978 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 54.09 cM
Mapping Data

5 experiments

SNPs within 2kb

651 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99473	protein coding gene	Chr7:99184356-99255979 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0032552	protein coding gene	Chr7:102338634-102418246 (+)
A/J	MGP_AJ_G0032526	protein coding gene	Chr7:99792478-99864542 (+)
AKR/J	MGP_AKRJ_G0032462	protein coding gene	Chr7:102163825-102243104 (+)
BALB/cJ	MGP_BALBcJ_G0032537	protein coding gene	Chr7:99470933-99543015 (+)
C3H/HeJ	MGP_C3HHeJ_G0032252	protein coding gene	Chr7:102514741-102591854 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0033035	protein coding gene	Chr7:106251865-106328006 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0030030	protein coding gene	Chr7:102215458-102288936 (+)
CAST/EiJ	MGP_CASTEiJ_G0031579	protein coding gene	Chr7:94058741-94130536 (+)
CBA/J	MGP_CBAJ_G0032219	protein coding gene	Chr7:109899867-109979438 (+)
DBA/2J	MGP_DBA2J_G0032371	protein coding gene	Chr7:98124509-98197463 (+)
FVB/NJ	MGP_FVBNJ_G0032328	protein coding gene	Chr7:97917799-97990838 (+)
LP/J	MGP_LPJ_G0032460	protein coding gene	Chr7:103650901-103731285 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0032360	protein coding gene	Chr7:111349121-111426398 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0033057	protein coding gene	Chr7:101435865-101514098 (+)
PWK/PhJ	MGP_PWKPhJ_G0031297	protein coding gene	Chr7:91218648-91292373 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0031140	protein coding gene	Chr7:88735109-88811494 (+)
WSB/EiJ	MGP_WSBEiJ_G0031696	protein coding gene	Chr7:102110791-102187568 (+)

Human Ortholog

ARRB1, arrestin beta 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

ARRB1, arrestin beta 1
Synonyms

ARB1, ARR1
Links

HGNC:711

NCBI Gene ID: 408

neXtProt AC: NX_P49407

UniProt: P49407
Chr Location

11q13.4; chr11:75260122-75351705 (-) GRCh38

MGI Vertebrate Homology

Arrb1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: ARRB1
Gene Tree

Arrb1

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Phenotype Summary

8 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotypes from multigenic genotypes
86 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

12
Chemically induced (other)

1
Endonuclease-mediated

3
Radiation induced

1
Targeted

7
Genomic Mutations

2 involving Arrb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygotes for targeted null mutations exhibit impaired quenching of rod photocurrent flash responses and greater sensitivity to beta-receptor agonist-stimulated ventricular ejection fraction.

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All GO Annotations

99
GO References

15

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

940
Tissues

53
cDNA Data

130
Literature Summary

7

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase arrb1

ZFIN arrb1

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All Sequences

77
RefSeq

19
UniProt

6
CCDS

CCDS21484.1, CCDS40032.1

Ensembl

ENSMUSG00000018909 (Evidence)
NCBI Gene

109689

			Length	Strain/Species	Flank
genomic	ENSMUSG00000018909	Ensembl Gene Model \| MGI Sequence Detail	71306	C57BL/6J	± kb
transcript	ENSMUST00000179755	Ensembl \| MGI Sequence Detail	7135	Not Applicable
polypeptide	ENSMUSP00000136963	Ensembl \| MGI Sequence Detail	419	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000004319 beta-arrestin-1

(term hierarchy)
InterPro Domains

IPR000698 Arrestin

IPR017864 Arrestin, conserved site

IPR011022 Arrestin C-terminal-like domain

IPR014752 Arrestin-like, C-terminal

IPR011021 Arrestin-like, N-terminal

IPR014753 Arrestin, N-terminal

IPR014756 Immunoglobulin E-set

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All nucleic 131

cDNA 131

Microarray probesets 4

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MGD-MRK-16247, MGI:1921360, MGI:2142217, MGI:2444556

Summaries

All 182

Developmental Gene Expression 7

Gene Ontology 15

Phenotypes 86
Earliest

J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
Latest

J:342402 Shao BZ, et al., Depletion of beta-arrestin-1 in macrophages enhances atherosclerosis in ApoE(-/-) mice. Int Immunopharmacol. 2023 Oct 20;125(Pt A):111085

TSS for Arrb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr68059	Chr7:99184350-99184391 (+)	-302 bp
Tssr68060	Chr7:99184469-99184487 (+)	-195 bp
Tssr68061	Chr7:99184507-99184518 (+)	-160 bp
Tssr68062	Chr7:99184646-99184705 (+)	3 bp
Tssr68063	Chr7:99184719-99184798 (+)	86 bp
Tssr68064	Chr7:99184859-99184947 (+)	230 bp
Tssr68065	Chr7:99185663-99185665 (+)	991 bp
Tssr2337	Chr7:99189634-99189641 (+)	4,965 bp
Tssr68066	Chr7:99219751-99219795 (+)	35,100 bp
Tssr68067	Chr7:99228782-99228811 (+)	44,124 bp
Tssr68068	Chr7:99228834-99228851 (+)	44,170 bp
Tssr68069	Chr7:99228901-99228916 (+)	44,236 bp
Tssr2338	Chr7:99228962-99228971 (+)	44,294 bp
Tssr68070	Chr7:99237280-99237331 (+)	52,633 bp
Tssr68071	Chr7:99243787-99243811 (+)	59,126 bp
Tssr68072	Chr7:99243812-99243837 (+)	59,152 bp
Tssr68073	Chr7:99243845-99243852 (+)	59,176 bp
Tssr2339	Chr7:99250884-99250922 (+)	66,230 bp
Tssr68074	Chr7:99253102-99253110 (+)	68,433 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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