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Eif3e Gene Detail
Summary
  • Symbol
    Eif3e
  • Name
    eukaryotic translation initiation factor 3, subunit E
  • Synonyms
    48kDa, eIF3-p46, eIF3-p48, Eif3s6, Int6
  • Feature Type
    protein coding gene
  • IDs
    MGI:99257
    NCBI Gene: 16341
  • Alliance
    genome feature page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:43113454-43146115 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 16.73 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    945 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99257
 protein coding gene Chr15:43113436-43146132 (-)
129S1/SvImJ ENSMUSG00200026959
 protein coding gene Chr15:40065437-40098032 (-)
A/J ENSMUSG00195033899
 protein coding gene Chr15:40050829-40083500 (-)
AKR/J ENSMUSG00220027393
 protein coding gene Chr15:39990186-40022856 (-)
BALB/cJ ENSMUSG00180031732
 protein coding gene Chr15:40033939-40066601 (-)
C3H/HeJ ENSMUSG00175024716
 protein coding gene Chr15:40245022-40277687 (-)
C57BL/6NJ ENSMUSG00215016054
 protein coding gene Chr15:40026225-40058887 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019768
 protein coding gene Chr15:37822398-37855372 (-)
CAST/EiJ ENSTCUG00005009946
 protein coding gene Chr15:40028215-40060877 (-)
CBA/J ENSMUSG00210017650
 protein coding gene Chr15:40181471-40214706 (-)
DBA/2J ENSMUSG00185032833
 protein coding gene Chr15:40147027-40180262 (-)
FVB/NJ ENSMUSG00205020641
 protein coding gene Chr15:40034694-40067363 (-)
JF1/MsJ ENSUMUG00000033631
 protein coding gene Chr15:40004540-40037135 (-)
LP/J ENSMUSG00230013824
 protein coding gene Chr15:43449193-43481788 (-)
NOD/ShiLtJ ENSMUSG00190024666
 protein coding gene Chr15:40113134-40146369 (-)
NZO/HlLtJ ENSMUSG00225037865
 protein coding gene Chr15:43825302-43858537 (-)
PWK/PhJ ENSLUMG00010030410
 protein coding gene Chr15:40165000-40197598 (-)
SPRET/EiJ ENSMSPG00010011882
 protein coding gene Chr15:40986087-41019322 (-)
WSB/EiJ ENSIUOG00005032078
 protein coding gene Chr15:40097396-40130065 (-)



Homology
more
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EIF3E, eukaryotic translation initiation factor 3 subunit E
  • Synonyms
    eIF3-p46, EIF3-P48, EIF3S6, INT6
  • Links
    NCBI Gene ID: 3646
    UniProt: P60228

  • Chr Location
    8q23.1; chr8:108162787-108443496 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit prenatal lethality with reduced embryo size, cell size and fetal membranes. Mice heterozygous for a null allele exhibit reduced size, weight, MEF cell proliferation and MEF translation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    41
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    656
  • Tissues
    28
  • cDNA Data
    19
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022336 Ensembl Gene Model | MGI Sequence Detail 32662 C57BL/6J ±  kb
    transcript ENSMUST00000022960 Ensembl | MGI Sequence Detail 1506 Not Applicable  
    polypeptide ENSMUSP00000022960 Ensembl | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006977 eukaryotic translation initiation factor 3 subunit E
      (term hierarchy)
    • InterPro Domains
      IPR016650 Eukaryotic translation initiation factor 3 subunit E
      IPR019010 Eukaryotic translation initiation factor 3 subunit E, N-terminal
      IPR000717 Proteasome component (PCI) domain
      IPR036390 Winged helix DNA-binding domain superfamily
    • GlyGen
      P60229 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 8
      cDNA 20
      Primer pair 1
      Antibodies 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-16016
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 4
      Gene Ontology 10
      Phenotypes 17
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:314131 Fujii K, et al., Controlling tissue patterning by translational regulation of signaling transcripts through the core translation factor eIF3c. Dev Cell. 2021 Nov 8;56(21):2928-2937.e9
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory