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Zp3 Gene Detail
Summary
  • Symbol
    Zp3
  • Name
    zona pellucida glycoprotein 3
  • Synonyms
    Zp-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:99215
    NCBI Gene: 22788
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:136008959-136017478 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 75.62 cM
  • Mapping Data
    38 experiments
Strain
Comparison
more
  • SNPs within 2kb
    410 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99215
 protein coding gene Chr5:136008953-136017478 (+)
129S1/SvImJ ENSMUSG00200041359
 protein coding gene Chr5:129795265-129803791 (+)
A/J ENSMUSG00195044633
 protein coding gene Chr5:129300525-129309097 (+)
AKR/J ENSMUSG00220045587
 protein coding gene Chr5:128796553-128805020 (+)
BALB/cJ ENSMUSG00180043633
 protein coding gene Chr5:129403531-129412104 (+)
C3H/HeJ ENSMUSG00175035878
 protein coding gene Chr5:131331284-131339855 (+)
C57BL/6NJ ENSMUSG00215044941
 protein coding gene Chr5:129450425-129458954 (+)
CAROLI/EiJ no annotation
CAST/EiJ ENSTCUG00005009807
 protein coding gene Chr5:128683676-128692036 (+)
CBA/J ENSMUSG00210007535
 protein coding gene Chr5:130148923-130157494 (+)
DBA/2J ENSMUSG00185051668
 protein coding gene Chr5:133164153-133172723 (+)
FVB/NJ ENSMUSG00205047498
 protein coding gene Chr5:129048550-129057121 (+)
JF1/MsJ ENSUMUG00000052539
 protein coding gene Chr5:136064864-136073171 (+)
LP/J ENSMUSG00230048359
 protein coding gene Chr5:137277736-137286307 (+)
NOD/ShiLtJ ENSMUSG00190042303
 protein coding gene Chr5:129103546-129112117 (+)
NZO/HlLtJ ENSMUSG00225023616
 protein coding gene Chr5:144959359-144967929 (+)
PWK/PhJ ENSLUMG00010015375
 protein coding gene Chr5:127903533-127911842 (+)
SPRET/EiJ ENSMSPG00010032590
 protein coding gene Chr5:131324111-131332919 (+)
WSB/EiJ ENSIUOG00005031553
 protein coding gene Chr5:131756529-131765096 (+)



Homology
more
  • Human Ortholog
    ZP3, zona pellucida glycoprotein 3
  • Vertebrate Orthologs
    8
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZP3, zona pellucida glycoprotein 3
  • Synonyms
    OOMD3, OZEMA3, Zp-3, ZP3A, ZP3B, ZPC
  • Links
    NCBI Gene ID: 7784
    UniProt: P21754

  • Chr Location
    7q11.23; chr7:76397518-76442071 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    7 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous female mutants are infertile. In these females oocytes lack a zona pellucida and cumulus-oocyte complexes are disrupted. Oocytes of heterozygous females have a thin zona, but females are fertile.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    61
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    619
  • Tissues
    9
  • cDNA Data
    31
  • Literature Summary
    18
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22788 NCBI Gene Model | MGI Sequence Detail 8520 C57BL/6J ±  kb
    transcript NM_011776 RefSeq | MGI Sequence Detail 1317 NIH Swiss  
    polypeptide P10761 UniProt | EBI | MGI Sequence Detail 424 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 15
      cDNA 31
      Primer pair 5
      Antibodies 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15969, MGD-MRK-15971
    References
    more
    • Summaries
      All 178
      Developmental Gene Expression 18
      Gene Ontology 22
      Phenotypes 22
    • Earliest
      J:384087 Greve JM, et al., Mouse egg extracellular coat is a matrix of interconnected filaments possessing a structural repeat. J Mol Biol. 1985 Jan 20;181(2):253-64
    • Latest
      J:391254 Stein P, et al., Beware of your "oocyte specific" Cre line: somatic cell Cre expression in several Zp3-Cre lines and the Gdf9-iCre transgenic line. Biol Reprod. 2026 Apr 30;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory