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Zfp42 Gene Detail
Summary
  • Symbol
    Zfp42
  • Name
    zinc finger protein 42
  • Synonyms
    Rex1, Rex-1, Zfp-42
  • Feature Type
    protein coding gene
  • IDs
    MGI:99187
    NCBI Gene: 22702
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:43748100-43760017 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 8, 23.89 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99187
protein coding gene Chr8:43748100-43760046 (-)
129S1/SvImJ MGP_129S1SvImJ_G0033566
protein coding gene Chr8:42219325-42232065 (-)
A/J MGP_AJ_G0033549
protein coding gene Chr8:40618437-40630281 (-)
AKR/J MGP_AKRJ_G0033472
protein coding gene Chr8:41797211-41811303 (-)
BALB/cJ MGP_BALBcJ_G0033544
protein coding gene Chr8:40746299-40758898 (-)
C3H/HeJ MGP_C3HHeJ_G0033254
protein coding gene Chr8:42218746-42230581 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034060
protein coding gene Chr8:43797842-43810045 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031010
protein coding gene Chr8:37075885-37087312 (-)
CAST/EiJ MGP_CASTEiJ_G0032582
protein coding gene Chr8:41708313-41722951 (-)
CBA/J MGP_CBAJ_G0033232
protein coding gene Chr8:45619897-45632822 (-)
DBA/2J MGP_DBA2J_G0033386
protein coding gene Chr8:40429515-40441845 (-)
FVB/NJ MGP_FVBNJ_G0033330
protein coding gene Chr8:39969356-39983316 (-)
LP/J MGP_LPJ_G0033475
protein coding gene Chr8:42298281-42310195 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0033372
protein coding gene Chr8:45675616-45688794 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034078
protein coding gene Chr8:42028306-42039629 (-)
PWK/PhJ MGP_PWKPhJ_G0032291
protein coding gene Chr8:39973282-39985837 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032123
protein coding gene Chr8:41178528-41192675 (-)
WSB/EiJ MGP_WSBEiJ_G0032697
protein coding gene Chr8:42201901-42215263 (-)



Homology
more
  • Human Ortholog
    ZFP42, ZFP42 zinc finger protein
  • Vertebrate Orthologs
    1
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZFP42, ZFP42 zinc finger protein
  • Synonyms
    REX1, REX-1, zfp-42, ZNF754
  • Links
    NCBI Gene ID: 132625
    neXtProt AC: NX_Q96MM3
    UniProt: Q96MM3

  • Chr Location
    4q35.2; chr4:187995771-188005246 (+)  GRCh38

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 4 alleles in 4 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele exhibit premature age-related male germ cell loss, abnormal sperm morphology, and mild testicular atrophy.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000051176 Ensembl Gene Model | MGI Sequence Detail 11918 C57BL/6J ±  kb
    transcript ENSMUST00000211248 Ensembl | MGI Sequence Detail 1837 Not Applicable  
    polypeptide ENSMUSP00000147606 Ensembl | MGI Sequence Detail 288 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 3
      cDNA 34
      Primer pair 7

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13848, MGD-MRK-13849, MGD-MRK-15884, MGD-MRK-15939
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 30
      Gene Ontology 10
      Phenotypes 16
    • Earliest
      J:10124 Hosler BA, et al., Expression of REX-1, a gene containing zinc finger motifs, is rapidly reduced by retinoic acid in F9 teratocarcinoma cells. Mol Cell Biol. 1989 Dec;9(12):5623-9
    • Latest
      J:345819 Wang F, et al., Roles of the Rlim-Rex1 axis during X chromosome inactivation in mice. Proc Natl Acad Sci U S A. 2023 Dec 26;120(52):e2313200120

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    04/02/2024
    MGI 6.23
    The Jackson Laboratory