Wnt3 MGI Mouse Gene Detail - MGI:98955 - wingless-type MMTV integration site family, member 3

Symbol

Wnt3
Name

wingless-type MMTV integration site family, member 3
Synonyms

Int-4, Wnt-3

Feature Type

protein coding gene
IDs

MGI:98955
NCBI Gene: 22415
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:103664976-103708783 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 67.50 cM
Mapping Data

37 experiments

SNPs within 2kb

339 from dbSNP Build 142
Strain Annotations

18
RFLP

7

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98955	protein coding gene	Chr11:103664976-103708854 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0019269	protein coding gene	Chr11:106882073-106925825 (+)
A/J	MGP_AJ_G0019237	protein coding gene	Chr11:102336663-102380586 (+)
AKR/J	MGP_AKRJ_G0019206	protein coding gene	Chr11:105483005-105527224 (+)
BALB/cJ	MGP_BALBcJ_G0019211	protein coding gene	Chr11:102775716-102819467 (+)
C3H/HeJ	MGP_C3HHeJ_G0019020	protein coding gene	Chr11:105711511-105755841 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0019661	protein coding gene	Chr11:110187683-110231631 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017286	protein coding gene	Chr11:99748688-99792100 (+)
CAST/EiJ	MGP_CASTEiJ_G0018574	protein coding gene	Chr11:106704054-106781804 (+)
CBA/J	MGP_CBAJ_G0018989	protein coding gene	Chr11:114761424-114811778 (+)
DBA/2J	MGP_DBA2J_G0019101	protein coding gene	Chr11:101835622-101879484 (+)
FVB/NJ	MGP_FVBNJ_G0019092	protein coding gene	Chr11:101358655-101407168 (+)
LP/J	MGP_LPJ_G0019170	protein coding gene	Chr11:107368135-107414645 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0019122	protein coding gene	Chr11:114101255-114145045 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0019698	protein coding gene	Chr11:105865828-105910779 (+)
PWK/PhJ	MGP_PWKPhJ_G0018338	protein coding gene	Chr11:102916511-102974270 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0018129	protein coding gene	Chr11:105617891-105663383 (+)
WSB/EiJ	MGP_WSBEiJ_G0018623	protein coding gene	Chr11:105872041-105916348 (+)

Human Ortholog

WNT3, Wnt family member 3

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

WNT3, Wnt family member 3
Synonyms

INT4, TETAMS
Links

HGNC:12782

NCBI Gene ID: 7473

neXtProt AC: NX_P56703

UniProt: P56703
Chr Location

17q21.31-q21.32; chr17:46762506-46833154 (-) GRCh38

MGI Vertebrate Homology

Wnt3 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: WNT3
Gene Tree

Wnt3

Diseases

1 with human WNT3 associations

				Human Disease	Mouse Models
				tetraamelia syndrome 1 IDs tetraamelia syndrome 1 DOID:0112192 OMIM:273395

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

29 phenotypes from 4 alleles in 4 genetic backgrounds
10 phenotypes from multigenic genotypes
1 images
38 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

15
Gene trapped

2
Targeted

12
Transgenic

1
Genomic Mutations

2 involving Wnt3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

25 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutants develop to the egg cylinder stage, but fail to form a primitive streak, mesoderm, or node, and die by embryonic day 10.5.

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All GO Annotations

56
GO References

17

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1653
Tissues

527
cDNA Data

27
Literature Summary

188

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase wnt3

ZFIN wnt3

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All Sequences

43
RefSeq

4
UniProt

5
CCDS

CCDS25523.1

Ensembl

ENSMUSG00000000125 (Evidence)
NCBI Gene

22415

			Length	Strain/Species	Flank
genomic	ENSMUSG00000000125	Ensembl Gene Model \| MGI Sequence Detail	43808	C57BL/6J	± kb
transcript	ENSMUST00000000127	Ensembl \| MGI Sequence Detail	3076	Not Applicable
polypeptide	ENSMUSP00000000127	Ensembl \| MGI Sequence Detail	355	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000017442 proto-oncogene Wnt-3

(term hierarchy)
InterPro Domains

IPR005817 Wnt

IPR009141 Wnt-3 protein

IPR043158 Wnt, C-terminal domain

IPR018161 Wnt protein, conserved site

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All nucleic 88

Genomic 20

cDNA 30

Primer pair 20

Other 18

Microarray probesets 3

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MGD-MRK-11421, MGD-MRK-15440, MGD-MRK-15450

Summaries

All 282

Developmental Gene Expression 188

Gene Ontology 17

Phenotypes 38
Earliest

J:9831 Buchberg AM, et al., A comprehensive genetic map of murine chromosome 11 reveals extensive linkage conservation between mouse and human. Genetics. 1989 May;122(1):153-61
Latest

J:346065 Su H, et al., Exploring the formation mechanism of short-tailed phenotypes in animals using mutant mice with the TBXT gene c.G334T developed by CRISPR/Cas9. Gene. 2024 Feb 23;910:148310

TSS for Wnt3:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr105357	Chr11:103664991-103665019 (+)	29 bp
Tssr105358	Chr11:103700554-103700556 (+)	35,579 bp
Tssr105359	Chr11:103701023-103701030 (+)	36,051 bp
Tssr105360	Chr11:103701049-103701059 (+)	36,078 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23