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Upk1b Gene Detail
Summary
  • Symbol
    Upk1b
  • Name
    uroplakin 1B
  • Synonyms
    Tspan20, Upk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98912
    NCBI Gene: 22268
  • Alliance
    genome feature page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:38593544-38620565 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 26.87 cM, cytoband B5-C2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    777 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98912
 protein coding gene Chr16:38593544-38620690 (-)
129S1/SvImJ ENSMUSG00200028488
 protein coding gene Chr16:35521869-35549251 (-)
A/J ENSMUSG00195010362
 protein coding gene Chr16:35068835-35095815 (-)
AKR/J ENSMUSG00220026764
 protein coding gene Chr16:35455515-35482514 (-)
BALB/cJ ENSMUSG00180013143
 protein coding gene Chr16:35284305-35311288 (-)
C3H/HeJ ENSMUSG00175030555
 protein coding gene Chr16:35511598-35538568 (-)
C57BL/6NJ ENSMUSG00215011786
 protein coding gene Chr16:35365523-35392673 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020750
 protein coding gene Chr16:35848291-35875094 (-)
CAST/EiJ ENSTCUG00005028241
 protein coding gene Chr16:35815651-35842612 (-)
CBA/J ENSMUSG00210026468
 protein coding gene Chr16:35568680-35595647 (-)
DBA/2J ENSMUSG00185022978
 protein coding gene Chr16:35471662-35498634 (-)
FVB/NJ ENSMUSG00205016916
 protein coding gene Chr16:35445016-35470651 (-)
JF1/MsJ ENSUMUG00000030022
 protein coding gene Chr16:35713158-35740650 (-)
LP/J ENSMUSG00230026184
 protein coding gene Chr16:38043759-38070746 (-)
NOD/ShiLtJ ENSMUSG00190019887
 protein coding gene Chr16:35586661-35613660 (-)
NZO/HlLtJ ENSMUSG00225028777
 protein coding gene Chr16:41143163-41170156 (-)
PWK/PhJ ENSLUMG00010028044
 protein coding gene Chr16:35618903-35646093 (-)
SPRET/EiJ ENSMSPG00010016035
 protein coding gene Chr16:35575354-35604432 (-)
WSB/EiJ ENSIUOG00005026522
 protein coding gene Chr16:35675945-35702967 (-)



Homology
more
  • Human Ortholog
    UPK1B, uroplakin 1B
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK1B, uroplakin 1B
  • Synonyms
    TSPAN20, UPIB, UPK1
  • Links
    NCBI Gene ID: 7348
    UniProt: O75841

  • Chr Location
    3q13.32; chr3:119173517-119205152 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotype references
Mice heterozygous for a reporter allele are viable, fertile, and physically and behaviorally normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    9
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1180
  • Tissues
    206
  • cDNA Data
    17
  • Literature Summary
    34
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 22268 NCBI Gene Model | MGI Sequence Detail 27022 C57BL/6J ±  kb
transcript NM_178924 RefSeq | MGI Sequence Detail 1769 C57BL/6  
polypeptide Q9Z2C6 UniProt | EBI | MGI Sequence Detail 260 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 26
    Genomic 1
    cDNA 18
    Primer pair 4
    Other 3
    Antibodies 4

    Microarray probesets 6
Other
Accession IDs
less
MGD-MRK-15365, MGD-MRK-15367, MGI:2146422
References
more
  • Summaries
    All 84
    Developmental Gene Expression 34
    Gene Ontology 8
    Phenotypes 16
  • Earliest
    J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
  • Latest
    J:390780 Qasrawi F, et al., DeltaNP63 regulates epithelial stratification and differentiation in the murine ureter. Am J Physiol Renal Physiol. 2026 Aug 1;331(2):F286-F303
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory