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Pgc Gene Detail
Summary
  • Symbol
    Pgc
  • Name
    progastricsin (pepsinogen C)
  • Synonyms
    2210410L06Rik, Upg1, Upg-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98909
    NCBI Gene: 109820
  • Alliance
  • Transcription Start Sites
    48 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr17:48037767-48045403 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.98 cM, cytoband C
  • Mapping Data
    29 experiments
Strain
Comparison
more
  • SNPs within 2kb
    73 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98909
protein coding gene Chr17:48037767-48045407 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023856
protein coding gene Chr17:48939553-48948726 (+)
A/J MGP_AJ_G0023816
protein coding gene Chr17:47679183-47686859 (+)
AKR/J MGP_AKRJ_G0023785
protein coding gene Chr17:48098060-48109085 (+)
BALB/cJ MGP_BALBcJ_G0023818
protein coding gene Chr17:47593127-47601545 (+)
C3H/HeJ MGP_C3HHeJ_G0023581
protein coding gene Chr17:48826613-48836202 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024262
protein coding gene Chr17:50981672-50992572 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021711
protein coding gene Chr17:44437070-44444588 (+)
CAST/EiJ MGP_CASTEiJ_G0023063
protein coding gene Chr17:48939247-48948790 (+)
CBA/J MGP_CBAJ_G0023558
protein coding gene Chr17:52836050-52846787 (+)
DBA/2J MGP_DBA2J_G0023686
protein coding gene Chr17:46435141-46443006 (+)
FVB/NJ MGP_FVBNJ_G0023652
protein coding gene Chr17:46092924-46100384 (+)
LP/J MGP_LPJ_G0023766
protein coding gene Chr17:49595145-49603612 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023680
protein coding gene Chr17:52311354-52321596 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024307
protein coding gene Chr17:48451568-48459083 (+)
PWK/PhJ MGP_PWKPhJ_G0022808
protein coding gene Chr17:45810365-45818867 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022623
protein coding gene Chr17:45342798-45350540 (+)
WSB/EiJ MGP_WSBEiJ_G0023128
protein coding gene Chr17:49038125-49048335 (+)



Homology
more
  • Human Ortholog
    PGC, progastricsin
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PGC, progastricsin
  • Synonyms
    PEPC, PGII
  • Links
    NCBI Gene ID: 5225
    neXtProt AC: NX_P20142
    UniProt: P20142

  • Chr Location
    6p21.1; chr6:41736711-41754109 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit premature death with decreased erythrocyte cell number, decreased hemoglobin content, decreased circulating alkaline phosphatase level, increased regenerative and globoid dysplasia, and decreased incidence of MNU-induced.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
DNA-templated transcription
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 109820 NCBI Gene Model | MGI Sequence Detail 7637 C57BL/6J ±  kb
    transcript NM_025973 RefSeq | MGI Sequence Detail 1384 ZRU/MplStud  
    polypeptide Q9D7R7 UniProt | EBI | MGI Sequence Detail 392 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 90
      cDNA 89
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15361, MGD-MRK-15363, MGI:1914363
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 12
      Gene Ontology 3
      Phenotypes 11
    • Earliest
      J:6576 Szymura JM, et al., Linkage of a gene controlling urinary pepsinogen with the major histocompatibility complex of the mouse. Immunogenetics. 1981;13(3):267-71
    • Latest
      J:338079 E Y, et al., The relationship between pepsinogen C and gastric carcinogenesis: a transgene and population study. BMC Cancer. 2023 Jun 8;23(1):520

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    11/28/2023
    MGI 6.22
    The Jackson Laboratory