Trap1a Gene Detail

Summary

• Symbol
  Trap1a
• Name
  tumor rejection antigen P1A
• Synonyms
  Tra-P1A

• Feature Type
  protein coding gene
• IDs
  MGI:98818
  NCBI Gene: 22037
• Alliance
  gene page
• Transcription Start Sites
  8 TSS

Location &
Maps

• Sequence Map
  ChrX:138234432-138238918 bp, + strand

  From NCBI annotation of GRCm39
  

• View this region in JBrowse
  

• Genome Browsers
  Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome X, 61.35 cM
• Mapping Data
  2 experiments

Strain
Comparison

• SNPs within 2kb
  174 from dbSNP Build 142
• Strain Annotations
  18

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98818	protein coding gene	ChrX:138234432-138238918 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0036122	protein coding gene	ChrX:136826621-136831110 (+)
A/J	MGP_AJ_G0036101	protein coding gene	ChrX:136206105-136210990 (+)
AKR/J	MGP_AKRJ_G0036025	protein coding gene	ChrX:140603870-140608307 (+)
BALB/cJ	MGP_BALBcJ_G0036090	protein coding gene	ChrX:134567157-134571483 (+)
C3H/HeJ	MGP_C3HHeJ_G0035799	protein coding gene	ChrX:136849968-136855279 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0036615	protein coding gene	ChrX:140864242-140868521 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0033440	protein coding gene	ChrX:127987700-127992333 (+)
CAST/EiJ	MGP_CASTEiJ_G0035090	protein coding gene	ChrX:117660455-117665888 (+)
CBA/J	MGP_CBAJ_G0035776	protein coding gene	ChrX:145142550-145148743 (+)
DBA/2J	MGP_DBA2J_G0035933	protein coding gene	ChrX:135407609-135411999 (+)
FVB/NJ	MGP_FVBNJ_G0035867	protein coding gene	ChrX:134634588-134639158 (+)
LP/J	MGP_LPJ_G0036025	protein coding gene	ChrX:137809447-137815395 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0035904	protein coding gene	ChrX:152676203-152680553 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0036651	protein coding gene	ChrX:136152454-136157795 (+)
PWK/PhJ	MGP_PWKPhJ_G0034783	protein coding gene	ChrX:114601741-114606718 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0034610	protein coding gene	ChrX:118192507-118197438 (+)
WSB/EiJ	MGP_WSBEiJ_G0035225	protein coding gene	ChrX:134458342-134462739 (+)

Homology

• MGI Vertebrate Homology
  Trap1a stringent orthology
  1 mouse;1 rat
  
• Gene Tree
  Trap1a
  

Human Diseases

• Mutations/Alleles
  1 with disease annotations

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  10 phenotypes from multigenic genotypes
  14 phenotype references
  

• All Mutations and Alleles
  15
• Endonuclease-mediated
  1
• Gene trapped
  7
• Targeted
  6
• Transgenic
  1
• Incidental Mutations
  APF
• Find Mice (IMSR)
  6 strains or lines available

Mice homozygous for a knock-out allele exhibit increased T cell avidity towards P1A35-43 and increased rejection of P815 tumors with increased survival.

Expression

• Assay Results
  712
• Tissues
  5
• cDNA Data
  35
• Literature Summary
  3

Images

Tissue x Stage Matrix

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas

Sequences &
Gene Models

• All Sequences
  30
• RefSeq
  2
• UniProt
  2
• CCDS
  CCDS30433.1

• Ensembl
  ENSMUSG00000051257 (Evidence)
• NCBI Gene
  22037

Representative Sequences			Length	Strain/Species
genomic	22037	NCBI Gene Model | MGI Sequence Detail	4487	C57BL/6J
transcript	NM_011635	RefSeq | MGI Sequence Detail	1178	ZRU/MplStud
polypeptide	P19473	UniProt | EBI | MGI Sequence Detail	224	Not Applicable

Protein
Information

• UniProt
  2 Sequences
• Protein Ontology
  PR:000016936 tumor rejection antigen P815A
  (term hierarchy)

Molecular
Reagents

• All nucleic 40

  Genomic 3

  cDNA 35

  Primer pair 2

  
  

  Microarray probesets 3

Other
Accession IDs

MGD-MRK-15218, MGD-MRK-15220

References

• Summaries
  All 34

  Developmental Gene Expression 3

  Diseases 1

  Phenotypes 14
• Earliest
  J:11176 Van den Eynde B, et al., The gene coding for a major tumor rejection antigen of tumor P815 is identical to the normal gene of syngeneic DBA/2 mice. J Exp Med. 1991 Jun 1;173(6):1373-84
• Latest
  J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;

TSS for Trap1a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr162145	ChrX:138234586-138234619 (+)	171 bp
Tssr162146	ChrX:138234656-138234667 (+)	230 bp
Tssr162147	ChrX:138234902-138234911 (+)	475 bp
Tssr162148	ChrX:138234998-138235005 (+)	570 bp
Tssr162149	ChrX:138236240-138236243 (+)	1,810 bp
Tssr162150	ChrX:138236592-138236605 (+)	2,167 bp
Tssr162151	ChrX:138236639-138236650 (+)	2,213 bp
Tssr162152	ChrX:138236656-138236680 (+)	2,236 bp