Top1 MGI Mouse Gene Detail - MGI:98788

Symbol

Top1
Name

topoisomerase (DNA) I
Synonyms

D130064I21Rik, Top-1

Feature Type

protein coding gene
IDs

MGI:98788
NCBI Gene: 21969
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr2:160487817-160564684 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 2, 80.96 cM, cytoband H2-3
Mapping Data

14 experiments

SNPs within 2kb

248 from dbSNP Build 142
Strain Annotations

18
RFLP

6

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98788	protein coding gene	Chr2:160487808-160564684 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0026805	protein coding gene	Chr2:165840663-165922930 (+)
A/J	MGP_AJ_G0026771	protein coding gene	Chr2:159172142-159253631 (+)
AKR/J	MGP_AKRJ_G0026742	protein coding gene	Chr2:163885983-163966175 (+)
BALB/cJ	MGP_BALBcJ_G0026780	protein coding gene	Chr2:159489327-159568864 (+)
C3H/HeJ	MGP_C3HHeJ_G0026522	protein coding gene	Chr2:164210307-164291013 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0027229	protein coding gene	Chr2:170745406-170835650 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0024599	protein coding gene	Chr2:152546438-152626949 (+)
CAST/EiJ	MGP_CASTEiJ_G0025984	protein coding gene	Chr2:164579881-164665065 (+)
CBA/J	MGP_CBAJ_G0026499	protein coding gene	Chr2:176875384-176962670 (+)
DBA/2J	MGP_DBA2J_G0026637	protein coding gene	Chr2:158355641-158433762 (+)
FVB/NJ	MGP_FVBNJ_G0026604	protein coding gene	Chr2:156759092-156836567 (+)
LP/J	MGP_LPJ_G0026740	protein coding gene	Chr2:165942867-166029532 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0026625	protein coding gene	Chr2:180592125-180683972 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0027285	protein coding gene	Chr2:163718929-163800321 (+)
PWK/PhJ	MGP_PWKPhJ_G0025718	protein coding gene	Chr2:157905802-157985066 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0025521	protein coding gene	Chr2:162604442-162691367 (+)
WSB/EiJ	MGP_WSBEiJ_G0026054	protein coding gene	Chr2:164617342-164697778 (+)

Human Ortholog

TOP1, DNA topoisomerase I

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TOP1, DNA topoisomerase I
Synonyms

TOPI
Links

HGNC:11986

NCBI Gene ID: 7150

neXtProt AC: NX_P11387

UniProt: P11387
Chr Location

20q12; chr20:41028822-41124487 (+) GRCh38.p7

Alliance of Genome Resources

Top1 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TOP1
Gene Tree

Top1

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Phenotype Summary

1 phenotype from 1 allele in 1 genetic background
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

290
Gene trapped

283
Targeted

7
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

204 strains or lines available

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All GO Annotations

47
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

718
Tissues

10
cDNA Data

25
Literature Summary

6

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase top1.1, top1.2

ZFIN top1a

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Top1 interacts with 301 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

67
RefSeq

8
UniProt

6
CCDS

CCDS16995.1

Ensembl

ENSMUSG00000070544 (Evidence)
NCBI Gene

21969

			Length	Strain/Species	Flank
genomic	21969	NCBI Gene Model \| MGI Sequence Detail	76868	C57BL/6J	± kb
transcript	NM_009408	RefSeq \| MGI Sequence Detail	3763	C57BL/6
polypeptide	Q04750	UniProt \| EBI \| MGI Sequence Detail	767	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000016542 type 1B DNA topoisomerase 1

(term hierarchy)
EC

5.6.2.1
InterPro Domains

IPR011010 DNA breaking-rejoining enzyme, catalytic core

IPR001631 DNA topoisomerase I

IPR018521 DNA topoisomerase I, active site

IPR014727 DNA topoisomerase I, catalytic core, alpha/beta subdomain

IPR014711 DNA topoisomerase I, catalytic core, alpha-helical subdomain, eukaryotic-type

IPR013500 DNA topoisomerase I, catalytic core, eukaryotic-type

IPR008336 DNA topoisomerase I, DNA binding, eukaryotic-type

IPR036202 DNA topoisomerase I, DNA binding, eukaryotic-type, N-terminal domain superfamily

IPR013034 DNA topoisomerase I, DNA binding, N-terminal domain 1

IPR013030 DNA topoisomerase I, DNA binding, N-terminal domain 2

IPR013499 DNA topoisomerase I, eukaryotic-type

IPR025834 Topoisomerase I C-terminal domain

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All nucleic 31

Genomic 5

cDNA 26

Microarray probesets 4

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MGD-MRK-15165, MGD-MRK-15167, MGI:2138977

Summaries

All 75

Developmental Gene Expression 6

Gene Ontology 11

Phenotypes 15
Earliest

J:14878 Rettenberger G, et al., Localization of the type I DNA topoisomerase gene in man and mouse. Cytogenet Cell Genet. 1991;58:2032 (Abstr.)
Latest

J:325942 Reijns MAM, et al., Signatures of TOP1 transcription-associated mutagenesis in cancer and germline. Nature. 2022 Feb;602(7898):623-631

TSS for Top1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr21388	Chr2:160487801-160487816 (+)	-8 bp
Tssr21389	Chr2:160487891-160487913 (+)	85 bp
Tssr21390	Chr2:160487916-160487927 (+)	105 bp
Tssr21391	Chr2:160487931-160487946 (+)	122 bp
Tssr21392	Chr2:160487958-160487977 (+)	151 bp
Tssr21393	Chr2:160509795-160509801 (+)	21,981 bp
Tssr21394	Chr2:160512039-160512092 (+)	24,249 bp
Tssr21395	Chr2:160512094-160512102 (+)	24,281 bp
Tssr21396	Chr2:160529590-160529620 (+)	41,788 bp
Tssr21397	Chr2:160540090-160540117 (+)	52,287 bp
Tssr21398	Chr2:160541527-160541531 (+)	53,712 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Copyright, and Privacy Statement Send questions and comments to User Support.	last database update 05/24/2023 MGI 6.22