About   Help   FAQ
Tnp2 Gene Detail
Summary
  • Symbol
    Tnp2
  • Name
    transition protein 2
  • Synonyms
    Tp-2, TP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98785
    NCBI Gene: 21959
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:10605799-10606519 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 16, 5.83 cM, cytoband B1-B3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    52 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98785
 protein coding gene Chr16:10605799-10606524 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022512
 protein coding gene Chr16:7615297-7616016 (-)
A/J MGP_AJ_G0022474
 protein coding gene Chr16:7197735-7198454 (-)
AKR/J MGP_AKRJ_G0022450
 protein coding gene Chr16:7517895-7518614 (-)
BALB/cJ MGP_BALBcJ_G0022478
 protein coding gene Chr16:7328411-7329130 (-)
C3H/HeJ MGP_C3HHeJ_G0022245
 protein coding gene Chr16:7603119-7603838 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022927
 protein coding gene Chr16:7762742-7763461 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020448
 protein coding gene Chr16:7343616-7344339 (-)
CAST/EiJ MGP_CASTEiJ_G0021772
 protein coding gene Chr16:7622203-7622922 (-)
CBA/J MGP_CBAJ_G0022214
 protein coding gene Chr16:8114499-8115218 (-)
DBA/2J MGP_DBA2J_G0022345
 protein coding gene Chr16:7200951-7201670 (-)
FVB/NJ MGP_FVBNJ_G0022321
 protein coding gene Chr16:7182195-7182914 (-)
LP/J MGP_LPJ_G0022413
 protein coding gene Chr16:7567611-7568330 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022343
 protein coding gene Chr16:7822747-7823466 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022940
 protein coding gene Chr16:7473411-7474130 (-)
PWK/PhJ MGP_PWKPhJ_G0021512
 protein coding gene Chr16:7409780-7410499 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021342
 protein coding gene Chr16:7531591-7532310 (-)
WSB/EiJ MGP_WSBEiJ_G0021820
 protein coding gene Chr16:7552023-7552733 (-)



Homology
more
  • Human Ortholog
    TNP2, transition protein 2
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TNP2, transition protein 2
  • Synonyms
    TP2
  • Links
    NCBI Gene ID: 7142
    neXtProt AC: NX_Q05952
    UniProt: Q05952

  • Chr Location
    16p13.13; chr16:11267748-11269533 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 2 alleles in 4 genetic backgrounds
    9 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Males homozygous for targeted null mutations produce small litters and exhibit incomplete chromatin condensation, sperm head abnormalities, and reduced sperm motility. Severity of the phenotype is influenced by genetic background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    14
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    723
  • Tissues
    2
  • cDNA Data
    94
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21959 NCBI Gene Model | MGI Sequence Detail 721 C57BL/6J ±  kb
    transcript NM_013694 RefSeq | MGI Sequence Detail 724 Not Specified  
    polypeptide P11378 UniProt | EBI | MGI Sequence Detail 117 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 103
      Genomic 4
      cDNA 95
      Primer pair 2
      Other 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-15160, MGD-MRK-15174
    References
    more
    • Summaries
      All 62
      Developmental Gene Expression 12
      Gene Ontology 14
      Phenotypes 9
    • Earliest
      J:8975 Kleene KC, et al., Characterization of a cDNA clone encoding a basic protein, TP2, involved in chromatin condensation during spermiogenesis in the mouse. J Biol Chem. 1987 Dec 25;262(36):17272-7
    • Latest
      J:330530 Dura M, et al., DNMT3A-dependent DNA methylation is required for spermatogonial stem cells to commit to spermatogenesis. Nat Genet. 2022 Apr;54(4):469-480
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory