Tk1 MGI Mouse Gene Detail - MGI:98763

Symbol

Tk1
Name

thymidine kinase 1
Synonyms

D530002A18Rik, Tk-1

Feature Type

protein coding gene
IDs

MGI:98763
NCBI Gene: 21877
Alliance

genome feature page
Transcription Start Sites

4 TSS

Sequence Map

Chr11:117706352-117716918 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 82.96 cM, cytoband E1-E2
Mapping Data

21 experiments

SNPs within 2kb

384 from dbSNP Build 142
Strain Annotations

19
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_98763	protein coding gene	Chr11:117706345-117716918 (-)
129S1/SvImJ	ENSMUSG00200050331	protein coding gene	Chr11:115074286-115084755 (-)
A/J	ENSMUSG00195028415	protein coding gene	Chr11:114748869-114759334 (-)
AKR/J	ENSMUSG00220029734	protein coding gene	Chr11:114899392-114909859 (-)
BALB/cJ	ENSMUSG00180046918	protein coding gene	Chr11:115033805-115044375 (-)
C3H/HeJ	ENSMUSG00175035404	protein coding gene	Chr11:115000512-115010973 (-)
C57BL/6NJ	ENSMUSG00215042385	protein coding gene	Chr11:114567706-114578272 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0017471	protein coding gene	Chr11:113695401-113705658 (-)
CAST/EiJ	ENSTCUG00005028353	protein coding gene	Chr11:114425317-114435724 (-)
CBA/J	ENSMUSG00210048401	protein coding gene	Chr11:114714573-114725040 (-)
DBA/2J	ENSMUSG00185023218	protein coding gene	Chr11:115027615-115038082 (-)
FVB/NJ	ENSMUSG00205035917	protein coding gene	Chr11:114872611-114883164 (-)
JF1/MsJ	ENSUMUG00000042568	protein coding gene	Chr11:115312750-115321628 (-)
LP/J	ENSMUSG00230050088	protein coding gene	Chr11:116093589-116104054 (-)
NOD/ShiLtJ	ENSMUSG00190046656	protein coding gene	Chr11:115094555-115105110 (-)
NZO/HlLtJ	ENSMUSG00225050708	protein coding gene	Chr11:118241753-118252218 (-)
PWK/PhJ	ENSLUMG00010023660	protein coding gene	Chr11:114827817-114838375 (-)
SPRET/EiJ	ENSMSPG00010031184	protein coding gene	Chr11:115392446-115405073 (-)
WSB/EiJ	ENSIUOG00005046195	protein coding gene	Chr11:114833048-114843903 (-)

Human Ortholog

TK1, thymidine kinase 1

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TK1, thymidine kinase 1
Links

HGNC:11830

NCBI Gene ID: 7083

UniProt: P04183
Chr Location

17q25.3; chr17:78172780-78187233 (-) GRCh38

MGI Vertebrate Homology

Tk1 stringent orthology
1 human;1 mouse;1 zebrafish
HCOP

vertebrate homology predictions: TK1
Gene Tree

Tk1

less

Phenotype Summary

24 phenotypes from 1 allele in 1 genetic background
2 phenotypes from multigenic genotypes
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

20
Endonuclease-mediated

5
Gene trapped

11
Targeted

4
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

27 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Nullizygous mice show partial postnatal lethality, poor fertility, hemosiderosis, lymphocyte and spleen anomalies, altered sublingual gland secretion, inflammation of the arteries, lung, liver and thyroid, abnormal spermatogenesis and glomerulosclerosis leading to kidney failure and premature death.

less

All GO Annotations

28
GO References

11

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

less

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

711
Tissues

106
cDNA Data

100
Literature Summary

10

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase tk1

ZFIN tk1

less

All Sequences

60
RefSeq

9
UniProt

2
CCDS

CCDS25692.1

Ensembl

ENSMUSG00000025574 (Evidence)
NCBI Gene

21877

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025574	Ensembl Gene Model \| MGI Sequence Detail	10567	C57BL/6J	± kb
transcript	ENSMUST00000026661	Ensembl \| MGI Sequence Detail	1440	Not Applicable
polypeptide	ENSMUSP00000026661	Ensembl \| MGI Sequence Detail	233	Not Applicable

less

UniProt

2 Sequences
Protein Ontology

PR:000024045 thymidine kinase

(term hierarchy)
EC

2.7.1.21
InterPro Domains

IPR027417 P-loop containing nucleoside triphosphate hydrolase

IPR001267 Thymidine kinase

IPR020633 Thymidine kinase, conserved site

less

All nucleic 112

Genomic 5

cDNA 100

Primer pair 1

Other 6

Microarray probesets 4

less

MGD-MRK-15121, MGD-MRK-15124, MGI:2444019

Summaries

All 98

Developmental Gene Expression 10

Gene Ontology 11

Phenotypes 19
Earliest

J:5857 McBreen P, et al., Synteny of the genes for thymidine kinase and galactokinase in the mouse and their assignment to mouse chromosome 11. Cytogenet Cell Genet. 1977;19(1):7-13
Latest

J:313619 Bedogni F, et al., Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034

TSS for Tk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr112047	Chr11:117718223-117718232 (-)	-1,310 bp
Tssr112046	Chr11:117716610-117716698 (-)	264 bp
Tssr112045	Chr11:117716593-117716602 (-)	320 bp
Tssr112044	Chr11:117709929-117709969 (-)	6,969 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24