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Timp2 Gene Detail
Summary
  • Symbol
    Timp2
  • Name
    tissue inhibitor of metalloproteinase 2
  • Synonyms
    D11Bwg1104e, Timp-2, TIMP-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98753
    NCBI Gene: 21858
  • Alliance
    gene page
  • Transcription Start Sites
    26 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:118191887-118246237 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 83.09 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    142 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98753
 protein coding gene Chr11:118191887-118246566 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019464
 protein coding gene Chr11:122624212-122680568 (-)
A/J MGP_AJ_G0019432
 protein coding gene Chr11:117186527-117241810 (-)
AKR/J MGP_AKRJ_G0019402
 protein coding gene Chr11:120741969-120800433 (-)
BALB/cJ MGP_BALBcJ_G0019407
 protein coding gene Chr11:117548116-117602870 (-)
C3H/HeJ MGP_C3HHeJ_G0019213
 protein coding gene Chr11:121045652-121101300 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019856
 protein coding gene Chr11:126371136-126441159 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017481
 protein coding gene Chr11:114194251-114245747 (-)
CAST/EiJ MGP_CASTEiJ_G0018767
 protein coding gene Chr11:122471762-122526771 (-)
CBA/J MGP_CBAJ_G0019184
 protein coding gene Chr11:131302218-131354481 (-)
DBA/2J MGP_DBA2J_G0019296
 protein coding gene Chr11:116573278-116627423 (-)
FVB/NJ MGP_FVBNJ_G0019288
 protein coding gene Chr11:116213643-116268511 (-)
LP/J MGP_LPJ_G0019366
 protein coding gene Chr11:122934962-122994244 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019321
 protein coding gene Chr11:130270360-130331805 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019895
 protein coding gene Chr11:121398076-121461001 (-)
PWK/PhJ MGP_PWKPhJ_G0018533
 protein coding gene Chr11:117943943-118001834 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018325
 protein coding gene Chr11:121127654-121184274 (-)
WSB/EiJ MGP_WSBEiJ_G0018819
 protein coding gene Chr11:121361811-121412046 (-)



Homology
more
  • Human Ortholog
    TIMP2, TIMP metallopeptidase inhibitor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TIMP2, TIMP metallopeptidase inhibitor 2
  • Synonyms
    CSC-21K, DDC8
  • Links
    NCBI Gene ID: 7077
    neXtProt AC: NX_P16035
    UniProt: P16035

  • Chr Location
    17q25.3; chr17:78852977-78925387 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human TIMP2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit impaired activation of pro-matrix metalloproteinase-2, but appear phenotypically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    40
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1111
  • Tissues
    188
  • cDNA Data
    313
  • Literature Summary
    54
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21858 NCBI Gene Model | MGI Sequence Detail 54351 C57BL/6J ±  kb
    transcript NM_011594 RefSeq | MGI Sequence Detail 3635 ZRU/MplStud  
    polypeptide P25785 UniProt | EBI | MGI Sequence Detail 220 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 340
      cDNA 316
      Primer pair 20
      Other 4

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-15111, MGD-MRK-15113, MGD-MRK-34056, MGI:106364
    References
    more
    • Summaries
      All 145
      Developmental Gene Expression 54
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:1243 Shimizu S, et al., Cloning and sequencing of the cDNA encoding a mouse tissue inhibitor of metalloproteinase-2. Gene. 1992 May 15;114(2):291-2
    • Latest
      J:342550 Gupta N, et al., Essential role of Mg(2+) in mouse preimplantation embryo development revealed by TRPM7 chanzyme-deficient gametes. Cell Rep. 2023 Oct 31;42(10):113232
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory