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Tgtp1 Gene Detail
Summary
  • Symbol
    Tgtp1
  • Name
    T cell specific GTPase 1
  • Synonyms
    Gtp2, Irgb6, Mg21, Tgtp
  • Feature Type
    protein coding gene
  • IDs
    MGI:98734
    NCBI Gene: 21822
  • Alliance
    genome feature page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:48876156-48883073 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 28.98 cM, cytoband B1.2
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    212 from dbSNP Build 142
  • Strain Annotations
    12
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98734
 protein coding gene Chr11:48876154-48884999 (-)
129S1/SvImJ ENSMUSG00200038833
 protein coding gene Chr11:45932242-45939253 (-)
A/J ENSMUSG00195034123
 protein coding gene Chr11:45876250-45883260 (-)
AKR/J no annotation
BALB/cJ ENSMUSG00180032471
 protein coding gene Chr11:45865883-45874726 (-)
C3H/HeJ ENSMUSG00175030581
 protein coding gene Chr11:45907980-45914990 (-)
C57BL/6NJ ENSMUSG00215026463
 protein coding gene Chr11:45834876-45841886 (-)
CAROLI/EiJ no annotation
CAST/EiJ no annotation
CBA/J ENSMUSG00210026225
 protein coding gene Chr11:45763957-45770967 (-)
DBA/2J ENSMUSG00185026543
 protein coding gene Chr11:45946218-45955065 (-)
FVB/NJ ENSMUSG00205022197
 protein coding gene Chr11:45893108-45900118 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230032275
 protein coding gene Chr11:47085438-47094284 (-)
NOD/ShiLtJ ENSMUSG00190029667
 protein coding gene Chr11:46018175-46025200 (-)
NZO/HlLtJ ENSMUSG00225034996
 protein coding gene Chr11:49065076-49073924 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    698
  • Tissues
    98
  • cDNA Data
    14
  • Literature Summary
    5
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21822 NCBI Gene Model | MGI Sequence Detail 6918 C57BL/6J ±  kb
transcript NM_011579 RefSeq | MGI Sequence Detail 2809 C57BL/6  
polypeptide Q62293 UniProt | EBI | MGI Sequence Detail 415 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    3 Sequences
  • GlyGen
    Q62293 1 site
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15077
References
more
  • Summaries
    All 43
    Developmental Gene Expression 5
    Gene Ontology 9
    Phenotypes 3
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:390619 Matsuo-Dapaah J, et al., IFNgamma-inducible Gbp4 and Irgb6 contribute to experimental cerebral malaria pathology in the olfactory bulb. mBio. 2025 Aug 13;16(8):e0124925
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/08/2026
MGI 6.24 		The Jackson Laboratory