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Tgm3 Gene Detail
Summary
  • Symbol
    Tgm3
  • Name
    transglutaminase 3, E polypeptide
  • Synonyms
    TG E, we
  • Feature Type
    protein coding gene
  • IDs
    MGI:98732
    NCBI Gene: 21818
  • Alliance
    genome feature page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:129854269-129892319 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 63.19 cM
  • Mapping Data
    35 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98732
 protein coding gene Chr2:129829700-129892319 (+)
129S1/SvImJ ENSMUSG00200046196
 protein coding gene Chr2:126896183-126934337 (+)
A/J ENSMUSG00195027911
 protein coding gene Chr2:126929457-126967536 (+)
AKR/J ENSMUSG00220042018
 protein coding gene Chr2:126689623-126727774 (+)
BALB/cJ ENSMUSG00180046816
 protein coding gene Chr2:126723535-126761540 (+)
C3H/HeJ ENSMUSG00175042438
 protein coding gene Chr2:127272557-127310512 (+)
C57BL/6NJ ENSMUSG00215031599
 protein coding gene Chr2:126777598-126815653 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024291
 protein coding gene Chr2:122798219-122836954 (+)
CAST/EiJ ENSTCUG00005036170
 protein coding gene Chr2:126054512-126092525 (+)
CBA/J ENSMUSG00210032100
 protein coding gene Chr2:127129479-127167440 (+)
DBA/2J ENSMUSG00185031010
 protein coding gene Chr2:126782445-126820504 (+)
FVB/NJ ENSMUSG00205031690
 protein coding gene Chr2:125944560-125982533 (+)
JF1/MsJ ENSUMUG00000014651
 protein coding gene Chr2:126599594-126637736 (+)
LP/J ENSMUSG00230035154
 protein coding gene Chr2:128531394-128569548 (+)
NOD/ShiLtJ ENSMUSG00190012343
 protein coding gene Chr2:126884006-126922160 (+)
NZO/HlLtJ ENSMUSG00225027363
 protein coding gene Chr2:136440198-136478348 (+)
PWK/PhJ ENSLUMG00010037340
 protein coding gene Chr2:126543449-126581458 (+)
SPRET/EiJ ENSMSPG00010025687
 protein coding gene Chr2:128940359-128976973 (+)
WSB/EiJ ENSIUOG00005042609
 protein coding gene Chr2:126707506-126745523 (+)



Homology
more
  • Human Ortholog
    TGM3, transglutaminase 3
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TGM3, transglutaminase 3
  • Synonyms
    TGE, UHS2
  • Links
    NCBI Gene ID: 7053
    UniProt: Q08188

  • Chr Location
    20p13; chr20:2296001-2341079 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 7 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    4 images
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU or null mutation exhibit rough-looking, curly hair. Null mutants display delayed skin barrier formation, loss of vibrissae, and brittle hairs.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1006
  • Tissues
    197
  • cDNA Data
    22
  • Literature Summary
    13
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027401 Ensembl Gene Model | MGI Sequence Detail 38051 C57BL/6J ±  kb
    transcript ENSMUST00000110299 Ensembl | MGI Sequence Detail 4135 Not Applicable  
    polypeptide ENSMUSP00000105928 Ensembl | MGI Sequence Detail 693 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 22
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-15074, MGD-MRK-15431, MGI:2139112, MGI:98947
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 13
      Gene Ontology 11
      Phenotypes 34
    • Earliest
      J:208 Hertwig P, Neue Mutationen und Koppelungsgruppen bei der Hausmaus. Z Indukt Abstamm Vererbungsl. 1942;80(1):220-246
    • Latest
      J:352165 Lin Y, et al., Denticleless E3 ubiquitin protein ligase (DTL) maintains the proliferation and differentiation of epidermis and hair follicles during skin development. Dev Dyn. 2024 Jul;253(7):635-647
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory